ChemicalBook > CAS DataBase List > NPS 2143

NPS 2143

Product Name
NPS 2143
CAS No.
284035-33-2
Chemical Name
NPS 2143
Synonyms
CS-276;CS-1600;NPS 2143;SB262470;SB 262470A;NPS-2143 base;NPS-2143 NPS2143;NPS 2143 USP/EP/BP;SB-262470(NPS-2143);NPS-2143 (SB-262470)
CBNumber
CB01512638
Molecular Formula
C24H25ClN2O2
Formula Weight
408.92
MOL File
284035-33-2.mol
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NPS 2143 Property

Boiling point:
608.4±55.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at RT
solubility 
≥40.9 mg/mL in DMSO; insoluble in H2O; ≥28.35 mg/mL in EtOH
form 
Powder
pka
13.67±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
3626
Product name
NPS2143 hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$908
Updated
2021/12/16
Usbiological
Product number
256031
Product name
NPS 2143 hydrochloride
Packaging
10mg
Price
$466
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0029514
Product name
2-CHLORO-6-[(2R)-3-[[1,1-DIMETHYL-2-(2-NAPHTHALENYL)ETHYL]AMINO]-2-HYDROXYPROPOXY]BENZONITRILE
Purity
95.00%
Packaging
5MG
Price
$505.71
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181069
Product name
NPS-2143(SB 262470A )
Purity
>98%
Packaging
100mg
Price
$578
Updated
2021/12/16
ChemScene
Product number
CS-0319
Product name
NPS-2143
Purity
99.34%
Packaging
100mg
Price
$660
Updated
2021/12/16
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NPS 2143 Chemical Properties,Usage,Production

Uses

NPS 2143 acts as a potent and selective antagonist for CaSR (Calcium-sensing receptor) which is involved in calcium blood concentration homeostasis.

Biological Activity

nps-2143 is a novel and selective antagonist of casr (ca2+-sensing receptor) with the ec50 value of 4.27mm for [ca2+]o [1].calcilytics nps-2143 has been reported to diminish the sensitivity of the casr for [ca2+]o, resulting in an attenuated signal transduction in vitro and increased secretion of pth in vivo. in addition, the ec50 values of nps-2143 are 4.27, 1.56, 1.61, 2.46, 2.07 and 3.15mm for the wild-type casr, mutant casr (t151r, p221l, e767q, g830s, and a844t), respectively. apart from these, in hek 293t cells expressing casr, nps-2143 has been revealed to inhibit the [ca2+]o-induced cytosolic calcium signal in a concentration-dependent manner [1]..

target

Ca(2+) receptor

References

[1] letz s1, rus r, haag c, dörr hg, schnabel d, möhlig m, schulze e, frank-raue k, raue f, mayr b, schöfl c. novel activating mutations of the calcium-sensing receptor: the calcilytic nps-2143 mitigates excessive signal transduction of mutant receptors. j clin endocrinol metab. 2010 oct;95(10):e229-33.

NPS 2143 Preparation Products And Raw materials

Raw materials

Preparation Products

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NPS 2143 Suppliers

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View Lastest Price from NPS 2143 manufacturers

Career Henan Chemical Co
Product
NPS 2143 284035-33-2
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2019-12-25

284035-33-2, NPS 2143Related Search:

Permethrin N,N-DIETHYLBENZAMIDE SB216763 MK-1775 (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid LDE225 (NVP-LDE225,Erismodegib) Dasatinib Nimodipine (S)-3-tert-Butylamino-1,2-propanediol BUNITROLOL HCL NPS 2143 Bunitrolol 2-CHLORO-6-METHOXYBENZONITRILE 3-(3-CHLOROPHENOXY)-N-METHYLPROPAN-1-AMINE 3-(3-chlorophenoxy)propan-1-amine Penirolol (R)-Bunitrolol

  • 2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2143)
  • 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile
  • NPS 2143 hydrochloride
  • 2-Chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile
  • 2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2
  • Benzonitrile, 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-
  • NPS 2143
  • SB-262470(NPS-2143)
  • 1-diMethyl-2-(2-naphthalenyl)ethyl]aMino]-2-hydroxypropoxy]-
  • 2-chloro-6-[(2R)-3-[[1
  • 2-Chloro-6-[3-[1, 1-diMethyl-2-(2-naphthyl)ethylaMino]-2(R)-hydroxypropoxy]benzonitrile
  • NPS-2143 base
  • NPS 2143 hydrochloride(SB-262470)
  • SB 262470A
  • NPS-2143 (SB-262470)
  • (R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propoxy)benzonitrile
  • SB262470
  • NPS-2143;NPS 2143; SB 262470A; NPS2143
  • CS-1600
  • NPS-2143(SB 262470A )
  • CS-276
  • NPS 2143, SB262470 hydrochloride
  • NPS 2143; SB 262470A ; NPS2143
  • NPS 2143;SB 262470A;NPS2143;SB262470
  • NPS 2143 USP/EP/BP
  • NPS-2143 NPS2143
  • 284035-33-2
  • C24H25ClNO2HCl
  • C24H25ClN2O2
  • API intermediates