ChemicalBook > CAS DataBase List > tert-Butylamine

tert-Butylamine

Product Name
tert-Butylamine
CAS No.
75-64-9
Chemical Name
tert-Butylamine
Synonyms
TERTIARY BUTYL AMINE;T-BUTYLAMINE;erbumine;1，1-Dimethylethylamine;Trimethylaminomethane;2-Methyl-2-propanamine;2-AMINO-2-METHYLPROPANE;cp11093;tert-C4H9NH2;TERT-BUTYLAMINE
CBNumber
CB8854238
Molecular Formula
C4H11N
Formula Weight
73.14
MOL File
75-64-9.mol
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tert-Butylamine Property

Melting point:
-67 °C (lit.)
Boiling point:
46 °C (lit.)
Density 
0.696 g/mL at 25 °C (lit.)
vapor density 
2.5 (vs air)
vapor pressure 
5.7 psi ( 20 °C)
refractive index 
n20/D 1.377(lit.)
Flash point:
−36.4 °F
storage temp. 
Store below +30°C.
solubility 
water: miscible1000g/L at 25°C
pka
10.68(at 25℃)
form 
Liquid
color 
Clear
PH
12 (100g/l, H2O, 20℃)
Odor
Like ammonia.
Odor Threshold
0.17ppm
explosive limit
1.5-9.2%(V)
Water Solubility 
MISCIBLE
Sensitive 
Air Sensitive
Merck 
14,1545
BRN 
605267
Dielectric constant
4.3099999999999996
Stability:
Stable. Incompatible with strong acids, strong oxidizing agents. Highly flammable.
CAS DataBase Reference
75-64-9(CAS DataBase Reference)
NIST Chemistry Reference
2-Propanamine, 2-methyl-(75-64-9)
EPA Substance Registry System
tert-Butylamine (75-64-9)
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Safety

Hazard Codes 
F,C,T
Risk Statements 
11-20/22-35-25-20-52/53
Safety Statements 
16-26-36/37/39-45-28A-61
RIDADR 
UN 3286 3/PG 2
WGK Germany 
1
RTECS 
EO3330000
F 
2-10
Autoignition Temperature
716 °F
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29211980
Hazardous Substances Data
75-64-9(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 80 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.01546
Product name
tert-Butylamine
Purity
for synthesis
Packaging
100mL
Price
$35.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01546
Product name
tert-Butylamine
Purity
for synthesis
Packaging
500mL
Price
$47.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01546
Product name
tert-Butylamine
Purity
for synthesis
Packaging
1L
Price
$64.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01546
Product name
tert-Butylamine
Purity
for synthesis
Packaging
35kg
Price
$1430
Updated
2024/03/01
Sigma-Aldrich
Product number
391433
Product name
tert-Butylamine
Purity
≥99.5%
Packaging
100ml
Price
$98.9
Updated
2024/03/01
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tert-Butylamine Chemical Properties,Usage,Production

Chemical Properties

tert-Butylamine is a colorless liquid with a typical amine-like odor. It is one of the four isomeric amines of butane, the others being n-butylamine, sec-butylamine and isobutylamine. Butylamines are highly flammable, colorless liquids (n-turns yellow on standing) with ammoniacal or fishlike odors. tert-Butylamine is used in the preparation of insecticides, pharmaceuticals, oil additives, and rubber accelerators.

Uses

tert-butylamine is used as a precursor for the preparation of rubber accelerators, pharmaceuticals and dyes. It is employed in synthesis of N-tert-butyl-acetamide, isoquinolines, pyridines, decumbenine, sulfontes, sulfonamides and methyl beta-ketophosphonate. It is also used in the study the effect of amines in influencing atmospheric sulfuric acid - water nucleation, hydroamination of terminal alkynes and measuring the surface acidity of solid catalyst. It acts as an indicator molecule in the study of NMR -based pH determination method.

Preparation

tert-Butylamine is produced commercially by direct amination of isobutylene using zeolite catalysts:
NH3 + CH2=C(CH3)2 → H2NC(CH3)3
The Ritter reaction of isobutene with hydrogen cyanide is not useful because it produces too much waste.
(CH3)2C=CH2 + HCN + H2O → (CH3)3CNHCHO
(CH3)3CNHCHO + H2O → (CH3)3CNH2 + HCO2H
In the laboratory, it can be prepared by the hydrogenolysis of 2,2-dimethylethylenimine, or via tert-butylphthalimide.

Application

Tert-Butylamine is also used for the production of herbicides, i.e., terbacil and the triazines terbutylazine, terbumeton, and terbutryn and insecticides (e.g., diafenthiuron). A derivative has also been proposed as stabilizer for cosmetics.

Production Methods

tert-Butylamine is manufactured by reacting isobutylamine with sulfuric acid followed by cyanide to tert-butylformamide. Hydrolysis yields t-butylamine. It is used as a solvent and in organic syntheses.

Definition

ChEBI: Tert-butylamine is a primary aliphatic amine that is ethylamine substituted by two methyl groups at position 1. It is a conjugate base of a tert-butylammonium.

General Description

Tert-butylamine appears as a clear colorless liquid with an ammonia-like odor. Flash point 70°F. Less dense (at 6.2 lb / gal) than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

Air & Water Reactions

Highly flammable. May be sensitive to air . Soluble in water.

Reactivity Profile

tert-Butylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. Undergoes highly exothermic reaction with 2,2-dibromo-1,3-dimethylcyclopropanoic acid [J. Chem. Soc., 1, 1979, 2324].

Hazard

Skin irritant. Flammable, dangerous fire risk.

Health Hazard

Inhalation causes irritation of nose, mouth, and lungs. Ingestion causes irritation of mouth and stomach. Contact with liquid causes severe irritation of eyes and moderate irritation of skin.

Fire Hazard

Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fire.

Safety Profile

Poison by ingestion. Moderately toxic to humans by inhalation. A corrosive liquid. See also n-BUTYLAMINE and AMINES. Very dangerous fire hazard when exposed to heat or flame. Very exothermic reaction with 2,2-dibromo-l,3 dimethylcyclopropanoic acid. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

Alert: (n-isomer): Possible risk of forming tumors, suspected of causing genetic defects, suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (sec-isomer): Drug. n-Butylamine is used in pharmaceuticals; dyestuffs, rubber, chemicals, emulsifying agents; photography, desizing agents for textiles; pesticides, and synthetic agents. sec-Butylamine is used as a fungistate. tert-Butylamine is used as a chemical intermediate in the production of tert-Butylaminoethyl methacrylate (a lube oil additive); as an intermediate in the production of rubber and in rust preventatives and emulsion deterrents in petroleum products. It is used in the manufacture of several drugs

Shipping

UN1125 n-Butylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material. UN2014 Isobutylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material

Purification Methods

Dry it with KOH or LiAlH4, and/or distil it from CaH2 or BaO. [Beilstein 4 IV 657.]

Incompatibilities

May form explosive mixture with air. May accumulate static electrical charges, and may causeignition of its vapors. n-Butylamine is a weak base; reacts with strong oxidizers and acids, causing fire and explosion hazard. Incompatible with organic anhydrides; isocyanates, vinyl acetate; acrylates, substituted allyls; alkylene oxides; epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. Attacks some metals in presence of moisture. The tert-isomer will attack some forms of plastics

Toxics Screening Level

The current ITSL for t-Butylamine is 60 μg/m3 annual average.

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner andscrubber. All federal, state, and local environmental regulations must be observed.

tert-Butylamine Preparation Products And Raw materials

Raw materials

2-Chloro-2-methylpropane Solid sodium hydroxide Isobutylene tert-Butanol TERT-BUTYLUREA PIVALAMIDE Urea Water HYDROGEN CYANIDE Government regulation Ammonium bisulfate Sulfuric acid

Preparation Products

N-(tert-Butyl)benzylamine 2-Aminoquinoline (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one 4-(Aminosulfonyl)phenylboronic acid CLENBUTEROL NADOLOL 2-Amino-6-bromophenol Nicosulfuron TERBUTALINE SULFATE Bunitrolol Rifampicin 4-AMINO-ALPHA-TERT-BUTYLAMINE-3,5-DICHLOROACETOPHENONE TERT-BUTYL ISOCYANIDE Bupropion Epristeride N-TERT-BUTYL-ALPHA-PHENYLNITRONE N,N-BIS(HYDROXYMETHYL)-TERTBUTYLAMINE N-tert-Butyl-2-benzothiazolesulfenamide Terbutryn
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tert-Butylamine Suppliers

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View Lastest Price from tert-Butylamine manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
tert-Butylamine 75-64-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-28
Ningxia Jinhua Chemical Co.,Ltd
Product
Tert-butylamine 75-64-9
Price
US $0.00/Kg/Drum
Min. Order
140KG
Purity
99%
Supply Ability
1000 Tons
Release date
2020-07-14
Changde Changlian Chemical Co., Ltd.
Product
tert-Butylamine 75-64-9
Price
US $0.00/Kg/Drum
Min. Order
140KG
Purity
99%
Supply Ability
1000 tons
Release date
2020-07-14

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