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Phenoxyacetyl chloride

Product Name
Phenoxyacetyl chloride
CAS No.
701-99-5
Chemical Name
Phenoxyacetyl chloride
Synonyms
SKL1266;AKOS BBS-00003927;Acyl chloride kind;Phenoxyacetyl chlori;phenoxy-acetylchlorid;PHENOXYACETYL CHLORIDE;LABOTEST-BB LT00643586;Acetylchloride,phenoxy-;Phenyloxyacetyl chloride;PhenoxyacetylChloride>
CBNumber
CB0227245
Molecular Formula
C8H7ClO2
Formula Weight
170.59
MOL File
701-99-5.mol
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Phenoxyacetyl chloride Property

Melting point:
100-100.5 °C
Boiling point:
225-226 °C (lit.)
Density 
1.235 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.534(lit.)
Flash point:
227 °F
storage temp. 
Store at RT.
form 
Liquid
color 
Clear slightly yellow to brown
Water Solubility 
Reacts with water.
Sensitive 
Moisture Sensitive
BRN 
607585
CAS DataBase Reference
701-99-5(CAS DataBase Reference)
NIST Chemistry Reference
Acetyl chloride, phenoxy-(701-99-5)
EPA Substance Registry System
Acetyl chloride, phenoxy- (701-99-5)
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Safety

Hazard Codes 
C
Risk Statements 
14-34-36/37
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
10-19
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29189090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
158623
Product name
Phenoxyacetyl chloride
Purity
98%
Packaging
10g
Price
$30.84
Updated
2024/03/01
Sigma-Aldrich
Product number
158623
Product name
Phenoxyacetyl chloride
Purity
98%
Packaging
50g
Price
$88.2
Updated
2024/03/01
TCI Chemical
Product number
P0113
Product name
Phenoxyacetyl Chloride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
P0113
Product name
Phenoxyacetyl Chloride
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$350
Updated
2024/03/01
Alfa Aesar
Product number
A13761
Product name
Phenoxyacetyl chloride, 98%
Packaging
50g
Price
$54.65
Updated
2024/03/01
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Phenoxyacetyl chloride Chemical Properties,Usage,Production

Chemical Properties

Colorless to brown liquid

Uses

Acylation of D- and DL-WV with phenoxyacetyl chloride, followed by cleavage of the t-butyl ester,afforded the penultimate penicilloic acids. Phenoxyacetyl chloride was used in the synthesis of series of macrocyclic bis-β-lactams, 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester, N-protected guanosine derivatives, useful in RNA synthesis, phenyloxyketene, for cycloaddition to imines leading to β-lactams. Treatment of iminophosphoranes with phenoxyacetyl chloride afforded respectively the trans- and cis-3-(acylamino)-p-lactams. By the oxidative addition of stannous fluoride to allyliodide, with 1, 2-O-isopropylidene-D-glyceraldehyde and phenoxyacetyl chloride results in the predominant formation of erythro homoallylester, which is in turn converted into 2-deoxy-D-ribose. The 4-disubstituted P-lactams (4a-c and 6a-b) were prepared through the reaction of N,N-diphenylhydrazones and N-methyl-N-phenylhydrazones of ketones with phenoxyacetyl chloride/Et3N in dichloromethane.

Uses

Phenoxyacetyl chloride was used in the synthesis of:

  • series of macrocyclic bis-β-lactams
  • 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester
  • N-protected guanosine derivatives, useful in RNA synthesis
  • phenyloxyketene, for cycloaddition to imines leading to β-lactams

Purification Methods

If it has no OH band in the IR then distil it in a vacuum, taking precautions for the moisture-sensitive compound. If it contains free acid (due to hydrolysis, OH bands in the IR), then add an equal volume of redistilled SOCl2, reflux for 2-3hours, evaporate and distil the residue in a vacuum as before. The amide has m 101o. [McElvain & Carney J Am Chem Soc 68 2592 1946, Beilstein 6 III 613.]

Phenoxyacetyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Phenoxyacetyl chloride Suppliers

Qujing Zhanyi Quanda Chemical Co., Ltd.
Tel
13267170933
Email
366546038@qq.com
Country
China
ProdList
72
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
Advantage
60
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
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View Lastest Price from Phenoxyacetyl chloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Phenoxyacetyl chloride 701-99-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Phenoxyacetyl Chloride 701-99-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
Phenoxyacetyl chloride 701-99-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-11

701-99-5, Phenoxyacetyl chlorideRelated Search:


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  • PHENOXYACETYL CHLORIDE
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  • Acetylchloride,phenoxy-
  • LABOTEST-BB LT00643586
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  • Acetyl chloride, 2-phenoxy-
  • SKL1266
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  • Carbonyl Compounds
  • Building Blocks
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  • Organic Building Blocks
  • Biochemistry
  • Nucleosides, Nucleotides & Related Reagents
  • Protecting Agents for Hydroxyl and Amino Groups
  • Protecting Agents, Phosphorylating Agents & Condensing Agents
  • Acid Halides
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