Phenoxyacetyl chloride
- Product Name
- Phenoxyacetyl chloride
- CAS No.
- 701-99-5
- Chemical Name
- Phenoxyacetyl chloride
- Synonyms
- SKL1266;AKOS BBS-00003927;Acyl chloride kind;Phenoxyacetyl chlori;phenoxy-acetylchlorid;PHENOXYACETYL CHLORIDE;LABOTEST-BB LT00643586;Acetylchloride,phenoxy-;Phenyloxyacetyl chloride;PhenoxyacetylChloride>
- CBNumber
- CB0227245
- Molecular Formula
- C8H7ClO2
- Formula Weight
- 170.59
- MOL File
- 701-99-5.mol
Phenoxyacetyl chloride Property
- Melting point:
- 100-100.5 °C
- Boiling point:
- 225-226 °C (lit.)
- Density
- 1.235 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.534(lit.)
- Flash point:
- 227 °F
- storage temp.
- Store at RT.
- form
- Liquid
- color
- Clear slightly yellow to brown
- Water Solubility
- Reacts with water.
- Sensitive
- Moisture Sensitive
- BRN
- 607585
- CAS DataBase Reference
- 701-99-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetyl chloride, phenoxy-(701-99-5)
- EPA Substance Registry System
- Acetyl chloride, phenoxy- (701-99-5)
Safety
- Hazard Codes
- C
- Risk Statements
- 14-34-36/37
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 10-19
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29189090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 158623
- Product name
- Phenoxyacetyl chloride
- Purity
- 98%
- Packaging
- 10g
- Price
- $30.84
- Updated
- 2024/03/01
- Product number
- 158623
- Product name
- Phenoxyacetyl chloride
- Purity
- 98%
- Packaging
- 50g
- Price
- $88.2
- Updated
- 2024/03/01
- Product number
- P0113
- Product name
- Phenoxyacetyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $30
- Updated
- 2024/03/01
- Product number
- P0113
- Product name
- Phenoxyacetyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 500g
- Price
- $350
- Updated
- 2024/03/01
- Product number
- A13761
- Product name
- Phenoxyacetyl chloride, 98%
- Packaging
- 50g
- Price
- $54.65
- Updated
- 2024/03/01
Phenoxyacetyl chloride Chemical Properties,Usage,Production
Chemical Properties
Colorless to brown liquid
Uses
Acylation of D- and DL-WV with phenoxyacetyl chloride, followed by cleavage of the t-butyl ester,afforded the penultimate penicilloic acids. Phenoxyacetyl chloride was used in the synthesis of series of macrocyclic bis-β-lactams, 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester, N-protected guanosine derivatives, useful in RNA synthesis, phenyloxyketene, for cycloaddition to imines leading to β-lactams. Treatment of iminophosphoranes with phenoxyacetyl chloride afforded respectively the trans- and cis-3-(acylamino)-p-lactams. By the oxidative addition of stannous fluoride to allyliodide, with 1, 2-O-isopropylidene-D-glyceraldehyde and phenoxyacetyl chloride results in the predominant formation of erythro homoallylester, which is in turn converted into 2-deoxy-D-ribose. The 4-disubstituted P-lactams (4a-c and 6a-b) were prepared through the reaction of N,N-diphenylhydrazones and N-methyl-N-phenylhydrazones of ketones with phenoxyacetyl chloride/Et3N in dichloromethane.
Uses
Phenoxyacetyl chloride was used in the synthesis of:
- series of macrocyclic bis-β-lactams
- 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester
- N-protected guanosine derivatives, useful in RNA synthesis
- phenyloxyketene, for cycloaddition to imines leading to β-lactams
Purification Methods
If it has no OH band in the IR then distil it in a vacuum, taking precautions for the moisture-sensitive compound. If it contains free acid (due to hydrolysis, OH bands in the IR), then add an equal volume of redistilled SOCl2, reflux for 2-3hours, evaporate and distil the residue in a vacuum as before. The amide has m 101o. [McElvain & Carney J Am Chem Soc 68 2592 1946, Beilstein 6 III 613.]
Phenoxyacetyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
Phenoxyacetyl chloride Suppliers
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View Lastest Price from Phenoxyacetyl chloride manufacturers
- Product
- Phenoxyacetyl chloride 701-99-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Phenoxyacetyl Chloride 701-99-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- Phenoxyacetyl chloride 701-99-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-11