ChemicalBook > CAS DataBase List > Phenoxyacetyl chloride

Phenoxyacetyl chloride

Product Name
Phenoxyacetyl chloride
CAS No.
701-99-5
Chemical Name
Phenoxyacetyl chloride
Synonyms
SKL1266;AKOS BBS-00003927;Acyl chloride kind;Phenoxyacetyl chlori;phenoxy-acetylchlorid;PHENOXYACETYL CHLORIDE;LABOTEST-BB LT00643586;Acetylchloride,phenoxy-;Phenyloxyacetyl chloride;PhenoxyacetylChloride>
CBNumber
CB0227245
Molecular Formula
C8H7ClO2
Formula Weight
170.59
MOL File
701-99-5.mol
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Phenoxyacetyl chloride Property

Melting point:
100-100.5 °C
Boiling point:
225-226 °C (lit.)
Density 
1.235 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.534(lit.)
Flash point:
227 °F
storage temp. 
Store at RT.
form 
Liquid
color 
Clear slightly yellow to brown
Water Solubility 
Reacts with water.
Sensitive 
Moisture Sensitive
BRN 
607585
InChI
InChI=1S/C8H7ClO2/c9-8(10)6-11-7-4-2-1-3-5-7/h1-5H,6H2
InChIKey
PKUPAJQAJXVUEK-UHFFFAOYSA-N
SMILES
C(Cl)(COC1=CC=CC=C1)=O
CAS DataBase Reference
701-99-5(CAS DataBase Reference)
NIST Chemistry Reference
Acetyl chloride, phenoxy-(701-99-5)
EPA Substance Registry System
Acetyl chloride, phenoxy- (701-99-5)
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Safety

Hazard Codes 
C
Risk Statements 
14-34-36/37
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
F 
10-19
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29189090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
158623
Product name
Phenoxyacetyl chloride
Purity
98%
Packaging
10g
Price
$50.35
Updated
2025/07/31
Sigma-Aldrich
Product number
158623
Product name
Phenoxyacetyl chloride
Purity
98%
Packaging
50g
Price
$144.4
Updated
2025/07/31
TCI Chemical
Product number
P0113
Product name
Phenoxyacetyl Chloride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
P0113
Product name
Phenoxyacetyl Chloride
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$350
Updated
2025/07/31
Sigma-Aldrich
Product number
158623
Product name
Phenoxyacetyl chloride
Purity
98%
Packaging
250g
Price
$321.65
Updated
2025/07/31
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Phenoxyacetyl chloride Chemical Properties,Usage,Production

Chemical Properties

Colorless to brown liquid

Uses

Acylation of D- and DL-WV with phenoxyacetyl chloride, followed by cleavage of the t-butyl ester,afforded the penultimate penicilloic acids. Phenoxyacetyl chloride was used in the synthesis of series of macrocyclic bis-β-lactams, 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester, N-protected guanosine derivatives, useful in RNA synthesis, phenyloxyketene, for cycloaddition to imines leading to β-lactams. Treatment of iminophosphoranes with phenoxyacetyl chloride afforded respectively the trans- and cis-3-(acylamino)-p-lactams. By the oxidative addition of stannous fluoride to allyliodide, with 1, 2-O-isopropylidene-D-glyceraldehyde and phenoxyacetyl chloride results in the predominant formation of erythro homoallylester, which is in turn converted into 2-deoxy-D-ribose. The 4-disubstituted P-lactams (4a-c and 6a-b) were prepared through the reaction of N,N-diphenylhydrazones and N-methyl-N-phenylhydrazones of ketones with phenoxyacetyl chloride/Et3N in dichloromethane.

Uses

Phenoxyacetyl chloride was used in the synthesis of:

  • series of macrocyclic bis-β-lactams
  • 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester
  • N-protected guanosine derivatives, useful in RNA synthesis
  • phenyloxyketene, for cycloaddition to imines leading to β-lactams

Purification Methods

If it has no OH band in the IR then distil it in a vacuum, taking precautions for the moisture-sensitive compound. If it contains free acid (due to hydrolysis, OH bands in the IR), then add an equal volume of redistilled SOCl2, reflux for 2-3hours, evaporate and distil the residue in a vacuum as before. The amide has m 101o. [McElvain & Carney J Am Chem Soc 68 2592 1946, Beilstein 6 III 613.]

Phenoxyacetyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Phenoxyacetyl chloride Suppliers

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View Lastest Price from Phenoxyacetyl chloride manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Phenoxyacetyl chloride 701-99-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
Phenoxyacetyl chloride 701-99-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Phenoxyacetyl Chloride 701-99-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

701-99-5, Phenoxyacetyl chlorideRelated Search:

Ammonium chloride Phenylacetyl chloride Choline chloride Sodium chloride Acetyl chloride Tamoxifen 2-Phenoxyethanol Phenoxybenzamine hydrochloride Bromoacetyl chloride Ethyl 2-(4-phenoxyphenoxy)ethylcarbamate Chloroacetyl chloride Benzyloxyacetyl chloride Benzyl chloride Calcium chloride Phenoxyacetic acid Polyvinyl chloride Potassium chloride 2-PHENOXYPROPIONYL CHLORIDE

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