ChemicalBook > CAS DataBase List > Phenoxyacetyl chloride

Phenoxyacetyl chloride

Product Name
Phenoxyacetyl chloride
CAS No.
701-99-5
Chemical Name
Phenoxyacetyl chloride
Synonyms
SKL1266;AKOS BBS-00003927;Acyl chloride kind;Phenoxyacetyl chlori;phenoxy-acetylchlorid;PHENOXYACETYL CHLORIDE;LABOTEST-BB LT00643586;Acetylchloride,phenoxy-;Phenyloxyacetyl chloride;PhenoxyacetylChloride>
CBNumber
CB0227245
Molecular Formula
C8H7ClO2
Formula Weight
170.59
MOL File
701-99-5.mol
More
Less

Phenoxyacetyl chloride Property

Melting point:
100-100.5 °C
Boiling point:
225-226 °C (lit.)
Density 
1.235 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.534(lit.)
Flash point:
227 °F
storage temp. 
Store at RT.
form 
Liquid
color 
Clear slightly yellow to brown
Water Solubility 
Reacts with water.
Sensitive 
Moisture Sensitive
BRN 
607585
CAS DataBase Reference
701-99-5(CAS DataBase Reference)
NIST Chemistry Reference
Acetyl chloride, phenoxy-(701-99-5)
EPA Substance Registry System
Acetyl chloride, phenoxy- (701-99-5)
More
Less

Safety

Hazard Codes 
C
Risk Statements 
14-34-36/37
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
F 
10-19
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29189090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
158623
Product name
Phenoxyacetyl chloride
Purity
98%
Packaging
10g
Price
$30.84
Updated
2024/03/01
Sigma-Aldrich
Product number
158623
Product name
Phenoxyacetyl chloride
Purity
98%
Packaging
50g
Price
$88.2
Updated
2024/03/01
TCI Chemical
Product number
P0113
Product name
Phenoxyacetyl Chloride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
P0113
Product name
Phenoxyacetyl Chloride
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$350
Updated
2024/03/01
Alfa Aesar
Product number
A13761
Product name
Phenoxyacetyl chloride, 98%
Packaging
50g
Price
$54.65
Updated
2024/03/01
More
Less

Phenoxyacetyl chloride Chemical Properties,Usage,Production

Chemical Properties

Colorless to brown liquid

Uses

Acylation of D- and DL-WV with phenoxyacetyl chloride, followed by cleavage of the t-butyl ester,afforded the penultimate penicilloic acids. Phenoxyacetyl chloride was used in the synthesis of series of macrocyclic bis-β-lactams, 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester, N-protected guanosine derivatives, useful in RNA synthesis, phenyloxyketene, for cycloaddition to imines leading to β-lactams. Treatment of iminophosphoranes with phenoxyacetyl chloride afforded respectively the trans- and cis-3-(acylamino)-p-lactams. By the oxidative addition of stannous fluoride to allyliodide, with 1, 2-O-isopropylidene-D-glyceraldehyde and phenoxyacetyl chloride results in the predominant formation of erythro homoallylester, which is in turn converted into 2-deoxy-D-ribose. The 4-disubstituted P-lactams (4a-c and 6a-b) were prepared through the reaction of N,N-diphenylhydrazones and N-methyl-N-phenylhydrazones of ketones with phenoxyacetyl chloride/Et3N in dichloromethane.

Uses

Phenoxyacetyl chloride was used in the synthesis of:

  • series of macrocyclic bis-β-lactams
  • 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester
  • N-protected guanosine derivatives, useful in RNA synthesis
  • phenyloxyketene, for cycloaddition to imines leading to β-lactams

Purification Methods

If it has no OH band in the IR then distil it in a vacuum, taking precautions for the moisture-sensitive compound. If it contains free acid (due to hydrolysis, OH bands in the IR), then add an equal volume of redistilled SOCl2, reflux for 2-3hours, evaporate and distil the residue in a vacuum as before. The amide has m 101o. [McElvain & Carney J Am Chem Soc 68 2592 1946, Beilstein 6 III 613.]

Phenoxyacetyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Phenoxyacetyl chloride Suppliers

Americas 1 Belgium 1 China 88 Europe 4 France 2 Germany 5 India 4 Japan 4 Slovakia 1 Switzerland 3 United Kingdom 10 United States 24 Global 147
Qujing Zhanyi Quanda Chemical Co., Ltd.
Tel
13267170933
Email
366546038@qq.com
Country
China
ProdList
72
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Shenyang Yuancheng Pharmaceutical Technology Co., Ltd.
Tel
024-31298370 15040047923
Fax
024-62665110
Email
yuanchengchem@163.com
Country
China
ProdList
252
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq：2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9347
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Shanghai Xingui Biotechnology Co., Ltd.
Tel
17501653715
Email
xingui2022@126.com
Country
China
ProdList
10021
Advantage
58
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4767
Advantage
60
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Shanghai YouPeng Chemical Co. Ltd.
Tel
021-69005955 13701776567
Fax
021-69005775
Email
youpengchem@163.com
Country
China
ProdList
4293
Advantage
56
Shanghai TongYuan Chemical Co., Ltd.
Tel
021-021-69182866 13701855675
Fax
021-69182022
Email
tongyuanchem@126.com
Country
China
ProdList
4321
Advantage
58
Shanghai Kaisai Chemical Co., Ltd
Tel
021-33516722 13701817765
Fax
021-33516776
Email
kaisaichem@163.com
Country
China
ProdList
4741
Advantage
58
Shanghai Rolead Chemical Technology Co., Ltd.
Tel
021-69992220 13701886816
Fax
021-69992237
Email
roleadchem@163.com
Country
China
ProdList
4750
Advantage
50
Shanghai Kangtuo Chemical Co., Ltd.
Tel
021-69185552 13701777608
Fax
021-69186006
Email
kangtuochem@163.com
Country
China
ProdList
4360
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Chengdu DingDang Pharmaceutical Co., Ltd.
Tel
028-86040038 13980902949;
Fax
028-85149890
Email
market@dingdangchem.com
Country
China
ProdList
1843
Advantage
55
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5902
Advantage
65
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
3495
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20806
Advantage
60
Guangzhou Jhd Chemical Reagent Co., Ltd.
Tel
020-84383047
Fax
020-84380294
Email
sales@jhd.com.cn
Country
China
ProdList
9186
Advantage
65
JinJin Le Chemical Co., Ltd
Tel
10106090
Email
jjlchem2@163.com
Country
China
ProdList
9981
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19800
Advantage
60
Jiaxing Deyi Chemical Co., Ltd.
Tel
0573-86-0573-85866609 13325730825
Fax
0573-85866609
Email
945717149@qq.com
Country
China
ProdList
8025
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718 +86-13336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29791
Advantage
60
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
15497
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6038 18902104717
Email
sales@heowns.com
Country
China
ProdList
21085
Advantage
60
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Jinan Liheng Biotechnology Co., Ltd.
Tel
0531-18763987518 18763987518
Email
levi@lihengpharm.com
Country
China
ProdList
1792
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34553
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52849
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49374
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29811
Advantage
58
Jiaxing Jilat Chemical Co. LTD
Tel
0573-82813639 15157377625
Fax
0573-82813637
Email
sales@jlightchem.com
Country
China
ProdList
167
Advantage
58
Shandong Nayazuo Chemical Technology Co. LTD
Tel
400-873-6778 18660992876
Fax
0539-6267369
Email
3584419101@qq.com
Country
China
ProdList
4970
Advantage
58
More
Less

View Lastest Price from Phenoxyacetyl chloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Phenoxyacetyl chloride 701-99-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Phenoxyacetyl Chloride 701-99-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
Phenoxyacetyl chloride 701-99-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-11

701-99-5, Phenoxyacetyl chlorideRelated Search:

Ammonium chloride Phenylacetyl chloride Choline chloride Sodium chloride Acetyl chloride Tamoxifen 2-Phenoxyethanol Phenoxybenzamine hydrochloride Bromoacetyl chloride Ethyl 2-(4-phenoxyphenoxy)ethylcarbamate Chloroacetyl chloride Benzyloxyacetyl chloride Benzyl chloride Calcium chloride Phenoxyacetic acid Potassium chloride Polyvinyl chloride 2-PHENOXYPROPIONYL CHLORIDE

  • AKOS BBS-00003927
  • PHENOXYACETYL CHLORIDE
  • Acyl chloride kind
  • Acetylchloride,phenoxy-
  • LABOTEST-BB LT00643586
  • phenoxy-acetylchlorid
  • Phenyloxyacetyl chloride
  • Phenoxyacetic acid chloride
  • Phenoxyacetyl chloride,98%
  • Phenoxyacetyl chlori
  • Phenoxyacetyl chloride, 98% 10GR
  • Phenoxyacetyl chloride, 98% 50GR
  • PhenoxyacetylChloride&gt
  • Acetyl chloride, 2-phenoxy-
  • SKL1266
  • 2-ACETYL-5-CHLORO-13-METHYLTHIANAPHTHENE
  • 701-99-5
  • C6H5OCH2COCl
  • Carbonyl Compounds
  • Building Blocks
  • Acid Halides
  • Organic Building Blocks
  • Biochemistry
  • Nucleosides, Nucleotides & Related Reagents
  • Protecting Agents for Hydroxyl and Amino Groups
  • Protecting Agents, Phosphorylating Agents & Condensing Agents
  • Acid Halides
  • Carbonyl Compounds
  • Organic Building Blocks