Pivaloyl chloride

ChemicalBook > CAS DataBase List > Pivaloyl chloride

Product Name: Pivaloyl chloride
CAS No.: 3282-30-2
Chemical Name: Pivaloyl chloride
Synonyms: PVCL;pivaloyl;TRIMETHYLACETYL CHLORIDE;PIVALYL CHLORIDE;PIVALIC ACID CHLORIDE;2,2-DIMETHYLPROPIONYL CHLORIDE;2,2-Dimethyl-propanoyl chloride;221-921-6;Pivalolyl chloride;JACS-3282-30-2
CBNumber: CB6477301
Molecular Formula: C5H9ClO
Formula Weight: 120.58
MOL File: 3282-30-2.mol

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Pivaloyl chloride Property

Melting point:: -56 °C
Boiling point:: 105-106 °C(lit.)
Density: 0.980 g/mL at 20 °C
vapor density: >1 (vs air)
vapor pressure: 36 mm Hg ( 20 °C)
refractive index: n20/D 1.412(lit.)
Flash point:: 48 °F
storage temp.: Store below +30°C.
solubility: Miscible with acetonitrile.
form: Liquid
color: Clear almost colorless to light pink
explosive limit: 1.9-7.4%(V)
Water Solubility: Hydrolysis
Sensitive: Moisture Sensitive
BRN: 385668
Stability:: Hygroscopic, Moisture Sensitive, Volatile
InChIKey: JVSFQJZRHXAUGT-UHFFFAOYSA-N
LogP: 1.680 (est)
CAS DataBase Reference: 3282-30-2(CAS DataBase Reference)
NIST Chemistry Reference: Propanoyl chloride, 2,2-dimethyl-(3282-30-2)
EPA Substance Registry System: Propanoyl chloride, 2,2-dimethyl- (3282-30-2)

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Safety

Hazard Codes: F,T+,T
Risk Statements: 11-14-22-26-34-23
Safety Statements: 16-26-36/37/39-45-38-28A
RIDADR: UN 2438 6.1/PG 1
WGK Germany: 1
F: 9-19
TSCA: Yes
HazardClass: 6.1
PackingGroup: I
HS Code: 29159080

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H290May be corrosive to metals

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H330Fatal if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T72605
Product name: Trimethylacetyl chloride
Purity: 99%
Packaging: 5ml
Price: $15.78
Updated: 2024/03/01

Sigma-Aldrich

Product number: T72605
Product name: Trimethylacetyl chloride
Purity: 99%
Packaging: 100ml
Price: $32.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.01276
Product name: Pivaloyl chloride
Purity: for synthesis
Packaging: 250ML
Price: $46.2
Updated: 2022/05/15

Alfa Aesar

Product number: A15051
Product name: Trimethylacetyl chloride, 98+%
Packaging: 100ml
Price: $25.8
Updated: 2024/03/01

Alfa Aesar

Product number: A15051
Product name: Trimethylacetyl chloride, 98+%
Packaging: 500ml
Price: $72.8
Updated: 2024/03/01

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Pivaloyl chloride Chemical Properties,Usage,Production

Chemical Properties

Colorless to yellow liquid

Uses

Widely used N-acylating agent for amines,1 Schiff bases,2 and pyrrolidinones3 as well as O-acylating agent for alcohols,4 lactones,5 and saccharides.6

Uses

Trimethylacetyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria. It is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament. In addition to this, it is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine. It is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 4569, 1988 DOI: 10.1016/S0040-4039(00)80549-3

General Description

Colorless fuming liquid with a pungent odor. Boiling point 105-106°F. Density 0.979 g / cm3. Flash point 48°F (8°C). Very toxic by inhalation, ingestion or skin absorption. Fumes irritate the eyes and mucous membranes. Corrosive to most metals and tissue.

Air & Water Reactions

Highly flammable. Fumes in air. Reacts vigorously and exothermically with water to form trimethylacetic acid and corrosive hydrochloric acid; both acids corrode metals and tissue [AAR 1991].

Reactivity Profile

Pivaloyl chloride is acidic. Incompatible with bases (including amines), strong oxidizing agents, and alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Flammable

Safety Profile

A corrosive irritant to skin, eyes, and mucous membranes. The liquid is flammable when exposed to heat, flame, or oxiduers. When heated to decomposition it emits toxic fumes of Cl-.

Purification Methods

First check the IR to see if OH bands are present. If absent, or present in small amounts, then redistil it under a moderate vacuum. If present in large amounts then treat it with oxalyl chloride or thionyl chloride and reflux for 2-3hours, evaporate and distil the residue. Strongly LACHRYMATORY -work in a fumecupboard. Store it in sealed ampoules under N2. [Traynham & Battiste J Org Chem 22 1551 1957, Grignard reactions: Whitmore et al. J Am Chem Soc 63 647 1941, Beilstein 2 IV 912.]

Pivaloyl chloride Preparation Products And Raw materials

Raw materials

Four-necked flask CARBON MONOXIDE 2-Methyl-1-propanol 2-Chloro-2-methylpropane Pivalic acid PHOSGENE Caprolactam Thionyl chloride

Preparation Products

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE TERT-BUTYLCARBAMIDINE HYDROCHLORIDE 2-(TRIMETHYLACETYL)THIOPHENE 3-Chloropivaloyl chloride 2,6-Di-tert-butyl-4-methylpyridine 3-tert-butyl-1H-1,2,4-triazole-5-thiol Ampicillin Clomazone AZIDITHION 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)PHENYLBORONIC ACID 1-AMINO-N-HYDROXY-2,2-DIMETHYLPROPAN-1-AMINE N-(3-FORMYL-2-PYRIDINYL)-2,2-DIMETHYLPROPANAMIDE 3-TERT-BUTYL-5-(4-BROMOPHENYL)-1,2,4-OXADIAZOLE Oxadiazon Ampicillin PIVALAMIDE N-(4-FORMYL-PYRIDIN-3-YL)-2,2-DIMETHYL-PROPIONAMIDE Chloromethyl pivalate N-(6-FLUORO-3-FORMYLPYRIDIN-2-YL)PIVALAMIDE 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)BENZALDEHYDE Amoxicillin trihydrate Efavirenz 2,2,2'-TRIMETHYLPROPIONANILIDE 2'-BENZYL-2,2-DIMETHYLPROPIONANILIDE Trimethylacetonitrile

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View Lastest Price from Pivaloyl chloride manufacturers

Speranza Chemical Co., Ltd.

Product: Pivaloyl Chloride 3282-30-2
Price: US $20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 300 Tons/ year
Release date: 2019-12-25

Hebei Weibang Biotechnology Co., Ltd

Product: Pivaloyl chloride 3282-30-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Hebei Yanxi Chemical Co., Ltd.

Product: Trimethylacetyl 3282-30-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-09-11

3282-30-2, Pivaloyl chlorideRelated Search:

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2,2-dimethyl-propanoylchlorid

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Pivalolyl chloride

pivaloyl

PIVALOYL CHLORIDE(PVCL)

Pivaloyl chloride(Trimethylacetyl chloride)

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Trimethylacetylchloride,98+%

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Pivaloylchlorid

Trimethylacetychloride

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trimethylacetylchloride，2，2-dimethyl propanoyl chloride

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2,2-Dimethylpropionic acid chloride

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2,2-Dimethylpropionyl Chloride Trimethylacetyl Chloride

PIVALOYL CHLORIDE FOR SYNTHESIS

JACS-3282-30-2

Propanoylchloride,2,2-dimethyl-

Pyvaloylchloride

tert-ValericchlorideCP108

221-921-6

NEOPENTANOYL CHLORIDE

PIVALIC ACID CHLORIDE

PIVALYL CHLORIDE

PIVALOYL CHLORIDE

PVCL

TRIMETHYLACETYL CHLORIDE

2,2-DIMETHYLPROPIONYL CHLORIDE

2,2-Dimethyl-propanoyl chloride

Pivoloyl chloride

PivaloylChloride&gt

JVSFQJZRHXAUGT-UHFFFAOYSA-N

Pivaloyl chloride (PCl)

4. Pivaloyl Chloride

Adefovir Dipivoxil Impurity 25

Pivaloyl Chloride/2,2-Dimethylpropanoyl Chloride

3282-30-2

638-29-2

3282-32-0

CH33CCOCl

Organic Building Blocks

Acid Halides

ACID CHLORIDE

Building Blocks

Carbonyl Compounds

Agrochemical Intermediates

Acid Halides

Building Blocks

Carbonyl Compounds