Pivaloyl chloride

ChemicalBook > CAS DataBase List > Pivaloyl chloride

Product Name: Pivaloyl chloride
CAS No.: 3282-30-2
Chemical Name: Pivaloyl chloride
Synonyms: PVCL;pivaloyl;TRIMETHYLACETYL CHLORIDE;PIVALYL CHLORIDE;PIVALIC ACID CHLORIDE;2,2-DIMETHYLPROPIONYL CHLORIDE;2,2-Dimethyl-propanoyl chloride;221-921-6;Pivalolyl chloride;JACS-3282-30-2
CBNumber: CB6477301
Molecular Formula: C5H9ClO
Formula Weight: 120.58
MOL File: 3282-30-2.mol

Less

Pivaloyl chloride Property

Melting point:: -56 °C
Boiling point:: 105-106 °C(lit.)
Density: 0.980 g/mL at 20 °C
vapor density: >1 (vs air)
vapor pressure: 36 mm Hg ( 20 °C)
refractive index: n20/D 1.412(lit.)
Flash point:: 48 °F
storage temp.: Store below +30°C.
solubility: Miscible with acetonitrile.
form: Liquid
color: Clear almost colorless to light pink
explosive limit: 1.9-7.4%(V)
Water Solubility: Hydrolysis
Sensitive: Moisture Sensitive
BRN: 385668
Stability:: Hygroscopic, Moisture Sensitive, Volatile
InChIKey: JVSFQJZRHXAUGT-UHFFFAOYSA-N
LogP: 1.680 (est)
CAS DataBase Reference: 3282-30-2(CAS DataBase Reference)
NIST Chemistry Reference: Propanoyl chloride, 2,2-dimethyl-(3282-30-2)
EPA Substance Registry System: Propanoyl chloride, 2,2-dimethyl- (3282-30-2)

Less

Safety

Hazard Codes: F,T+,T
Risk Statements: 11-14-22-26-34-23
Safety Statements: 16-26-36/37/39-45-38-28A
RIDADR: UN 2438 6.1/PG 1
WGK Germany: 1
F: 9-19
TSCA: Yes
HazardClass: 6.1
PackingGroup: I
HS Code: 29159080

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H290May be corrosive to metals

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H330Fatal if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T72605
Product name: Trimethylacetyl chloride
Purity: 99%
Packaging: 5ml
Price: $15.78
Updated: 2024/03/01

Sigma-Aldrich

Product number: T72605
Product name: Trimethylacetyl chloride
Purity: 99%
Packaging: 100ml
Price: $32.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.01276
Product name: Pivaloyl chloride
Purity: for synthesis
Packaging: 250ML
Price: $46.2
Updated: 2022/05/15

Alfa Aesar

Product number: A15051
Product name: Trimethylacetyl chloride, 98+%
Packaging: 100ml
Price: $25.8
Updated: 2024/03/01

Alfa Aesar

Product number: A15051
Product name: Trimethylacetyl chloride, 98+%
Packaging: 500ml
Price: $72.8
Updated: 2024/03/01

Less

Pivaloyl chloride Chemical Properties,Usage,Production

Chemical Properties

Colorless to yellow liquid

Uses

Widely used N-acylating agent for amines,1 Schiff bases,2 and pyrrolidinones3 as well as O-acylating agent for alcohols,4 lactones,5 and saccharides.6

Uses

Trimethylacetyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria. It is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament. In addition to this, it is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine. It is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 4569, 1988 DOI: 10.1016/S0040-4039(00)80549-3

General Description

Colorless fuming liquid with a pungent odor. Boiling point 105-106°F. Density 0.979 g / cm3. Flash point 48°F (8°C). Very toxic by inhalation, ingestion or skin absorption. Fumes irritate the eyes and mucous membranes. Corrosive to most metals and tissue.

Air & Water Reactions

Highly flammable. Fumes in air. Reacts vigorously and exothermically with water to form trimethylacetic acid and corrosive hydrochloric acid; both acids corrode metals and tissue [AAR 1991].

Reactivity Profile

Pivaloyl chloride is acidic. Incompatible with bases (including amines), strong oxidizing agents, and alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Flammable

Safety Profile

A corrosive irritant to skin, eyes, and mucous membranes. The liquid is flammable when exposed to heat, flame, or oxiduers. When heated to decomposition it emits toxic fumes of Cl-.

Purification Methods

First check the IR to see if OH bands are present. If absent, or present in small amounts, then redistil it under a moderate vacuum. If present in large amounts then treat it with oxalyl chloride or thionyl chloride and reflux for 2-3hours, evaporate and distil the residue. Strongly LACHRYMATORY -work in a fumecupboard. Store it in sealed ampoules under N2. [Traynham & Battiste J Org Chem 22 1551 1957, Grignard reactions: Whitmore et al. J Am Chem Soc 63 647 1941, Beilstein 2 IV 912.]

Pivaloyl chloride Preparation Products And Raw materials

Raw materials

Four-necked flask CARBON MONOXIDE 2-Methyl-1-propanol 2-Chloro-2-methylpropane Pivalic acid PHOSGENE Caprolactam Thionyl chloride

Preparation Products

2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE TERT-BUTYLCARBAMIDINE HYDROCHLORIDE 2-(TRIMETHYLACETYL)THIOPHENE 3-Chloropivaloyl chloride 2,6-Di-tert-butyl-4-methylpyridine 3-tert-butyl-1H-1,2,4-triazole-5-thiol Ampicillin Clomazone AZIDITHION 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)PHENYLBORONIC ACID 1-AMINO-N-HYDROXY-2,2-DIMETHYLPROPAN-1-AMINE N-(3-FORMYL-2-PYRIDINYL)-2,2-DIMETHYLPROPANAMIDE 3-TERT-BUTYL-5-(4-BROMOPHENYL)-1,2,4-OXADIAZOLE Oxadiazon Ampicillin PIVALAMIDE N-(4-FORMYL-PYRIDIN-3-YL)-2,2-DIMETHYL-PROPIONAMIDE Chloromethyl pivalate N-(6-FLUORO-3-FORMYLPYRIDIN-2-YL)PIVALAMIDE 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)BENZALDEHYDE Amoxicillin trihydrate Efavirenz 2,2,2'-TRIMETHYLPROPIONANILIDE 2'-BENZYL-2,2-DIMETHYLPROPIONANILIDE Trimethylacetonitrile

Less

Pivaloyl chloride Suppliers

Belgium 1 Canada 1 China 321 Europe 4 France 2 Germany 8 India 31 Japan 5 Slovakia 1 South Korea 2 Switzerland 3 Ukraine 1 United Kingdom 7 United States 34 Global 421

Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 9030
Advantage: 60

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25004
Advantage: 65

Beijing Tianyukanghong Chemical Technology Co., Ltd.

Tel: 010-57794770 13552605092
Fax: 010-60593781
Email: tianyukanghong@163.com
Country: China
ProdList: 343
Advantage: 55

Tianjin Zhongxin Chemtech Co., Ltd.

Tel: 022-66880623
Fax: 86(0)22-66880086
Email: sales@tjzxchem.com
Country: China
ProdList: 614
Advantage: 60

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12426
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9552
Advantage: 66

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696;
Email: info@hanhongsci.com
Country: China
ProdList: 42982
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Shandong Xiya Chemical Co., Ltd

Tel: 13355009207 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18739
Advantage: 57

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7815
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14443
Advantage: 57

Henan Wanxiang Chemical Industry Co., Ltd.

Tel: 0371-56669001 13949088811
Fax: 0371-56669008
Email: Sales@58chem.cn
Country: China
ProdList: 89
Advantage: 62

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4388
Advantage: 65

Aemon Chemical

Tel: 0086-755-86198205
Email: acinfo@aemonchem.com
Country: China
ProdList: 1937
Advantage: 57

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11714
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Shanghai Nuohey Chemical Co., Ltd.

Tel: 021-52212593 13761626812
Fax: +86 (21) 51062076
Email: sales@nuohey.com
Country: China
ProdList: 10692
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9725
Advantage: 55

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9872
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17779
Advantage: 75

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9901
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18216
Advantage: 56

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9552
Advantage: 55

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4576
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8033
Advantage: 55

Zouping Mingxing Chemical Co.,Ltd.

Tel: 86-13605431940 13605431940
Fax: 0086-0543-2240079
Email: zpmxchemical@126.com
Country: China
ProdList: 2002
Advantage: 62

Wuxi Zhangkun Biochemical Technology Co., Ltd.

Tel: +86 0510-85629785
Fax: +86 0510-85625359
Country: China
ProdList: 2331
Advantage: 58

Shandong Xinhua Pharmceutical Co.,LTD

Tel: 0533-2196801
Fax: 0533-2196817
Email: yaojianyong@xhzy.com
Country: China
ProdList: 70
Advantage: 60

Sinfachem Limited

Tel: 025-84683399 13952017251
Fax: 025-84683112
Email: sales@sinfachem.com
Country: China
ProdList: 217
Advantage: 56

Beijing Universal Century Technology Co., Ltd.

Tel: 400-8706899
Fax: 400-8706899
Email: hysj_bj.com
Country: China
ProdList: 3585
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9986
Advantage: 55

Huainan Kedi Chemical Factory

Tel: 0554-2106669
Fax: 0554-2666215
Email: sales1@kedichem.com
Country: China
ProdList: 4928
Advantage: 55

RiZhao LiDeShi Chemical Co., Ltd.

Tel: 010-51268198
Fax: 010-63833209
Email: leadershipchem@126.com
Country: China
ProdList: 2549
Advantage: 58

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9353
Advantage: 58

Shanghai ideal Industrial Co., Ltd.

Tel: 021-58957966 18930537195
Fax: 021-60899437
Email: wouchina@126.com
Country: China
ProdList: 3033
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13358
Advantage: 58

GuangTuo Chemical (Shanghai) Co., Ltd.

Tel: 021-60899189-8001 18918189673
Fax: 021-60899304
Email: gtchem@126.com
Country: China
ProdList: 2661
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15185
Advantage: 58

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5223
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10287
Advantage: 55

Founding chemical products Technology Development Co., Ltd.

Tel: 0310-6697998 03106697998
Fax: 0310-6697696
Email: losartan@crotonic-anhydride.com
Country: China
ProdList: 96
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15878
Advantage: 55

SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.

Tel: 021-69106960 13701823733
Fax: 021-69106780
Email: 13701823733@163.com
Country: China
ProdList: 4776
Advantage: 60

Less

View Lastest Price from Pivaloyl chloride manufacturers

Speranza Chemical Co., Ltd.

Product: Pivaloyl Chloride 3282-30-2
Price: US $20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 300 Tons/ year
Release date: 2019-12-25

Shandong Luning Pharmaceutical Co., Ltd.

Product: Trimethylacetyl chloride 3282-30-2
Price: US $3500.00/T
Min. Order: 1T
Purity: 99%
Supply Ability: 600T
Release date: 2020-11-06

Hebei Duling International Trade Co. LTD

Product: Pivaloyl chloride 3282-30-2
Price: US $9.90/L
Min. Order: 1L
Purity: 98%
Supply Ability: 500mt/month
Release date: 2022-10-21

3282-30-2, Pivaloyl chlorideRelated Search:

Acetoxyacetyl chloride Dimethyl phthalate 3,3-Dimethylbutyryl chloride Dimethyl sulfate Phenoxyacetyl chloride Mepiquat chloride Ammonium chloride Dimethyl carbonate Dimethyl ether Potassium chloride Thionyl chloride Sodium chloride ETHANE 5-Bromovaleryl chloride Xylene Trichloroacetyl chloride N,N-Dimethylformamide Benzyloxyacetyl chloride

2,2-dimethyl-propanoylchlorid

Acetyl chloride, trimethyl-

Neopantanoyl chloride

Pivalolyl chloride

pivaloyl

PIVALOYL CHLORIDE(PVCL)

Pivaloyl chloride(Trimethylacetyl chloride)

Primethylacetyl chloride

Pivalpyl chloride

Pivaloyl chlorode

Trimethylacetylchloride,98+%

Trimethylacetyl

TRIMETHYLACETYL CHLORIDE/PIVALOYL CHLORIDE

Pivaloylchlorid

Trimethylacetychloride

PIVALOYL CHLORIDE extrapure

tert-Valeryl chloride

trimethylacetylchloride，2，2-dimethyl propanoyl chloride

Pivaloyl chloride ,99%

2,2-Dimethylpropanoic acid chloride

2,2-Dimethylpropionic acid chloride

Trimethyacetyl Chloride

Trimethylacetyl chloride,99%

2,2-Dimethylpropionyl Chloride Trimethylacetyl Chloride

PIVALOYL CHLORIDE FOR SYNTHESIS

JACS-3282-30-2

Propanoylchloride,2,2-dimethyl-

Pyvaloylchloride

tert-ValericchlorideCP108

221-921-6

NEOPENTANOYL CHLORIDE

PIVALIC ACID CHLORIDE

PIVALYL CHLORIDE

PIVALOYL CHLORIDE

PVCL

TRIMETHYLACETYL CHLORIDE

2,2-DIMETHYLPROPIONYL CHLORIDE

2,2-Dimethyl-propanoyl chloride

Pivoloyl chloride

PivaloylChloride&gt

JVSFQJZRHXAUGT-UHFFFAOYSA-N

Pivaloyl chloride (PCl)

4. Pivaloyl Chloride

Adefovir Dipivoxil Impurity 25

Pivaloyl Chloride/2,2-Dimethylpropanoyl Chloride

3282-30-2

638-29-2

3282-32-0

CH33CCOCl

Organic Building Blocks

Acid Halides

ACID CHLORIDE

Building Blocks

Carbonyl Compounds

Agrochemical Intermediates

Acid Halides

Building Blocks

Carbonyl Compounds