Chloromethyl pivalate

Product Name: Chloromethyl pivalate
CAS No.: 18997-19-8
Chemical Name: Chloromethyl pivalate
Synonyms: POM;POM-CL;PIVALOYLOXYMETHYL CHLORIDE;Chloromethyl 2,2-dimethylpropanoate;CMPV;hloromethyl pivalate;Adefovir Impurity 13;chloromethylepivalate;CHLOROMETHYL PIVALATE;CHLOROMETHYL PIVARATE
CBNumber: CB6171175
Molecular Formula: C6H11ClO2
Formula Weight: 150.6
MOL File: 18997-19-8.mol

More

Less

Chloromethyl pivalate Property

Melting point:: <-40°C
Boiling point:: 146-148 °C (lit.)
Density: 1.045 g/mL at 25 °C (lit.)
refractive index: n20/D 1.417(lit.)
Flash point:: 104 °F
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Sparingly)
form: Liquid
Specific Gravity: 1.038
color: Clear colorless to slightly yellow
Water Solubility: Miscible with most organic solvents. Immiscible with water.
BRN: 1560838
InChIKey: GGRHYQCXXYLUTL-UHFFFAOYSA-N
CAS DataBase Reference: 18997-19-8(CAS DataBase Reference)
NIST Chemistry Reference: Propanoic acid, 2,2-dimethyl-, chloromethyl ester(18997-19-8)
EPA Substance Registry System: Propanoic acid, 2,2-dimethyl-, chloromethyl ester (18997-19-8)

More

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 10-20/21/22-36/37/38
Safety Statements: 16-26-36-41-36/37/39
RIDADR: UN 3272 3/PG 3
WGK Germany: 3
TSCA: Yes
HazardClass: 3
PackingGroup: III
HS Code: 29159000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 141186
Product name: Chloromethyl pivalate
Purity: 97%
Packaging: 25g
Price: $55.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 141186
Product name: Chloromethyl pivalate
Purity: 97%
Packaging: 100g
Price: $87.4
Updated: 2024/03/01

TCI Chemical

Product number: P1012
Product name: Chloromethyl Pivalate [Amino-Protecting Agent]
Purity: >99.0%(GC)
Packaging: 25g
Price: $26
Updated: 2024/03/01

TCI Chemical

Product number: P1012
Product name: Chloromethyl Pivalate [Amino-Protecting Agent]
Purity: >99.0%(GC)
Packaging: 100g
Price: $66
Updated: 2024/03/01

Alfa Aesar

Product number: A11967
Product name: Chloromethyl pivalate, 97%
Packaging: 25g
Price: $28.65
Updated: 2024/03/01

More

Less

Chloromethyl pivalate Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

Chloromethyl pivalate was used in the synthesis of pivaloyloxy methyl ester of ofloxacin as prodrug. It was used as the reagent during the synthesis of an isoindoline-annulated, tricyclic sultam library via microwave-assisted, continuous-flow organic synthesis.

Application

Chloromethyl pivalate is a pharmaceutical intermediate compound used in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonomethoxyethyl)adenine. It is used as a protecting agent for the N-protection of amines. It is also used in the preparation of thivaloyloxymethyl ester of ofloxacin as a prodrug. It is also used in the preparation of sulbactam pivoxil by reaction with the sodium salt of sulbactam. Besides, it is used as a reagent in the synthesis of isoindoline cyclic and continuous flow organic synthesis.

General Description

Chloromethyl pivalate reacts with sodium salt of sulbactam to yield sulbactam pivoxil. It undergoes acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to yield bis(pivaloyloxymethyl) PMEA.

Synthesis

Chloromethyl pivalate is prepared by the reaction of formaldehyd and pivaloyl chloride. The specific synthesis steps are as follows:
A mixture of pivaloyl chloride (8.56 g, 71 mmol), paraformaldehyde (2.13 g, 71 mmol) and zinc chloride (75 mg, 0.55 mmol) was stirred at 80 °C for 2 h. Purification by vacuum distillation afforded chloromethyl pivalate (41) as a colourless oil (6.29 g, 44.7 mmol, 59%). bp 80 °C/15 mmHg [lit.1 bp 80-81 °C/15 mmHg]; 1H NMR (400 MHz, CDCl3) δ 1.24 (9H, s, tBu), 5.72 (2H, s, CH2).

Chloromethyl pivalate Preparation Products And Raw materials

Raw materials

Zinc chloride Paraformaldehyde Pivaloyl chloride

Preparation Products

PIVALOYLOXYMETHYL 6-AMINOPENICILANATE Pivaloyloxymethyl6-(phenylacetamido)penicillanate

More

Less

Chloromethyl pivalate Suppliers

Americas 1 Belgium 3 Canada 1 China 282 Europe 3 France 2 Germany 6 India 9 Japan 3 Slovakia 1 South Korea 3 Switzerland 4 United Kingdom 9 United States 33 Global 360

Shanghai TongYuan Chemical Co., Ltd.

Tel: 021-021-69182866 13701855675
Fax: 021-69182022
Email: tongyuanchem@126.com
Country: China
ProdList: 4331
Advantage: 58

TaiZhou ZhiCheng Chemicals & Technology Co., LTD.

Tel: 0523-82837785 13365232216
Fax: 0523-87913272
Email: info@jszchg.com
Country: China
ProdList: 244
Advantage: 60

Founding chemical products Technology Development Co., Ltd.

Tel: 0310-6697998 03106697998
Fax: 0310-6697696
Email: losartan@crotonic-anhydride.com
Country: China
ProdList: 96
Advantage: 58

Handan Huajun Chemicals Co., Ltd.

Tel: 0310-8166583 13303008150
Fax: +86-310-8166573
Email: 884971191@qq.com
Country: China
ProdList: 18
Advantage: 55

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2210
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

More

Less

View Lastest Price from Chloromethyl pivalate manufacturers

Handan Huajun chemicals Co.,Ltd

Product: Chloromethyl pivalate 18997-19-8
Price: US $13.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 500MT
Release date: 2024-01-18

Hebei Yanxi Chemical Co., Ltd.

Product: Chloromethyl pivalate 18997-19-8
Price: US $30.00-10.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-17

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Chloromethyl pivalate 18997-19-8
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 20 tons
Release date: 2021-07-29

18997-19-8, Chloromethyl pivalateRelated Search:

DIMETHYLTHEXYLSILYL CHLORIDE 2-Chloro-2-methylpropane Methyl propionate Oxalyl chloride Methyl methacrylate Beclomethasone dipropionate Methyl chloroacetate tert-Butyldimethylsilyl chloride Methyl trimethylacetate Choline chloride Zinc chloride Calcium chloride Tris(trimethylsilyl)phosphate Chloromethyl butyrate Sodium chloride METHYL VALERATE BUTYL OLEATE Clobetasol propionate

Chloromethyl 2,2-dimethylpropanoate

Methanol, chloro-, pivalate

Chloromethyl Pivalate , (2,2-Dimethylpropanoic acid chlormetyl ester)

ChloroMethyl pivalate, 99+% 100GR

Chloromethyl Trimethylacetate 2,2-Dimethylpropionic Acid Chloromethyl Ester Pivalic Acid Chloromethyl Ester Trimethylacetic Acid Chloromethyl Ester

ChloroMethyl pivalate 97%

Pivalic acid Methyl chloride

hloromethyl pivalate

chloromethylepivalate

VLOOKUP(C9,[1]Export!$D:$H,5,0)

4-chloro-2,2-dimethylbutanoate

Adefovir Impurity 13

2,2-dimethyl-propanoicacichloromethylester

POM

POM-CL

PIVALOYLOXYMETHYL CHLORIDE

PIVALIC ACID CHLOROMETHYL ESTER

TRIMETHYLACETIC ACID CHLOROMETHYL ESTER

CHLOROMETHYL TRIMETHYLACETATE

CHLOROMETHYL PIVALATE

CHLOROMETHYL PIVARATE

CHLOROMETHYL 2,2-DIMETHYLPROPIONATE

CMPV

Chloromethyl Pivalate [Amino-Protecting Agent]

CHLORO METHYL PIVILATE

2,2-Dimethylpropanoic acid chloromethyl ester

2,2-DIMETHYLPROPIONIC ACID CHLOROMETHYL ESTER

Pivaloxymethylchlorde

Chloromethyl pivalate, 99+%

Propanoic acid, 2,2-dimethyl-, chloromethyl ester

Pivaloyloxymethyl chloride, POM-Cl

(2,2-Dimethyl-1-oxopropoxy)methyl chloride

ChloromethylPivalate[Amino-ProtectingAgent]&gt

Chloromethyl Chloromethyl pivalatepivalate

POM-Cl Chloromethyl Pivalate

Chloromethyl pivalateQ: What is Chloromethyl pivalate Q: What is the CAS Number of Chloromethyl pivalate Q: What is the storage condition of Chloromethyl pivalate Q: What are the applications of Chloromethyl pivalate

TIANFUCHEM ChloroMethyl pivalate

Adefovir Impurity 13 CRS

Choro Methyl Pivalate

18997-19-8

CH33CCO2CH2Cl

CH33CCOOCH2Cl

C6 to C7

Carbonyl Compounds

Building Blocks

Esters

Organic Building Blocks

Other Products

API

Building Blocks

C6 to C7

Carbonyl Compounds

Chemical Synthesis

Esters

Organic Building Blocks

Pharmaceutical Intermediates

Phosgene Derivatives

Miscellaneous