2,4-Dichloro-5-nitropyrimidine
- Product Name
- 2,4-Dichloro-5-nitropyrimidine
- CAS No.
- 49845-33-2
- Chemical Name
- 2,4-Dichloro-5-nitropyrimidine
- Synonyms
- JR-6659, 2,4-Dichloro-5-nitropyrimidine, 97%;oro-5-nitropyrimidine;2,4-DICHLORO-5-NITROPYRIMIDINE;5-Nitro-2,4-Dichloro pyrimidine;2,4-Dichloro-5-nitro-1,3-diazine;2,4-Dichloro-5-nitropyrimidine>2,4- twochloro -5-nitropyriMidine;Pyrimidine, 2,4-dichloro-5-nitro-;2,4-DICHLORO-5-NITROPYRIMIDINE 97%;2,4-Dichloro-5-nitropyrimidine ,97%
- CBNumber
- CB4148131
- Molecular Formula
- C4HCl2N3O2
- Formula Weight
- 193.98
- MOL File
- 49845-33-2.mol
2,4-Dichloro-5-nitropyrimidine Property
- Melting point:
- 28-32 °C
- Boiling point:
- 0.9 °C0.5 mm Hg
- Density
- 2.0263 (rough estimate)
- refractive index
- 1.6100 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- -6.02±0.29(Predicted)
- form
- Liquid or Low Melting Solid
- color
- Clear yellow
- Sensitive
- Moisture Sensitive
- InChI
- InChI=1S/C4HCl2N3O2/c5-3-2(9(10)11)1-7-4(6)8-3/h1H
- InChIKey
- INUSQTPGSHFGHM-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C([N+]([O-])=O)C(Cl)=N1
- CAS DataBase Reference
- 49845-33-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 658340
- Product name
- 2,4-Dichloro-5-nitropyrimidine
- Purity
- 97%
- Packaging
- 10g
- Price
- $89.5
- Updated
- 2025/07/31
- Product number
- 658340
- Product name
- 2,4-Dichloro-5-nitropyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $28.3
- Updated
- 2023/06/20
- Product number
- D3721
- Product name
- 2,4-Dichloro-5-nitropyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $57
- Updated
- 2025/07/31
- Product number
- D3721
- Product name
- 2,4-Dichloro-5-nitropyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $169
- Updated
- 2025/07/31
- Product number
- 658340
- Product name
- 2,4-Dichloro-5-nitropyrimidine
- Purity
- 97%
- Packaging
- 50g
- Price
- $753
- Updated
- 2025/07/31
2,4-Dichloro-5-nitropyrimidine Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
Intermediate in a solid-phase synthesis of diaminopurines.1
Uses
2,4-Dichloro-5-nitropyrimidine (cas# 49845-33-2) is a compound useful in organic synthesis.
Synthesis
611-08-5
49845-33-2
General procedure for the synthesis of 2,4-dichloro-5-nitropyrimidine from 5-nitropyrimidine-2,4(1H,3H)-dione: 5-nitrouracil (6.28 g, 0.040 mol) was mixed with phosphorus triclosan (26 mL), and N,N-dimethylaniline (8 mL) was slowly added under stirring conditions. The reaction mixture was then heated to 110 °C and maintained at this temperature for 8 hours. Upon completion of the reaction, the excess trichlorophosphorus was removed by distillation. The remaining mixture was ground and separated by silica gel column chromatography. Finally, the collected fractions were concentrated to give 6.2 g of yellow oily liquid product in 94% yield.
References
[1] Patent: CN106432239, 2017, A. Location in patent: Paragraph 0066; 0071; 0072
[2] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 2, p. 321 - 328
[3] Tetrahedron Letters, 2006, vol. 47, # 50, p. 8897 - 8900
[4] Patent: WO2010/83645, 2010, A1. Location in patent: Page/Page column 27
[5] Patent: US7256196, 2007, B1. Location in patent: Page/Page column 8; 9-10
2,4-Dichloro-5-nitropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloro-5-nitropyrimidine manufacturers
- Product
- 2,4-Dichloro-5-nitropyrimidine 49845-33-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-09
- Product
- 2,4-Dichloro-5-nitropyrimidine 49845-33-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-14
- Product
- 2,4-Dichloro-5-nitropyrimidine 49845-33-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27