ChemicalBook > CAS DataBase List > 2,4-Dichloro-5-nitropyrimidine

2,4-Dichloro-5-nitropyrimidine

Product Name
2,4-Dichloro-5-nitropyrimidine
CAS No.
49845-33-2
Chemical Name
2,4-Dichloro-5-nitropyrimidine
Synonyms
JR-6659, 2,4-Dichloro-5-nitropyrimidine, 97%;oro-5-nitropyrimidine;2,4-DICHLORO-5-NITROPYRIMIDINE;5-Nitro-2,4-Dichloro pyrimidine;2,4-Dichloro-5-nitro-1,3-diazine;2,4-Dichloro-5-nitropyrimidine>2,4- twochloro -5-nitropyriMidine;Pyrimidine, 2,4-dichloro-5-nitro-;2,4-DICHLORO-5-NITROPYRIMIDINE 97%;2,4-Dichloro-5-nitropyrimidine ,97%
CBNumber
CB4148131
Molecular Formula
C4HCl2N3O2
Formula Weight
193.98
MOL File
49845-33-2.mol
More
Less

2,4-Dichloro-5-nitropyrimidine Property

Melting point:
28-32 °C
Boiling point:
0.9 °C0.5 mm Hg
Density 
2.0263 (rough estimate)
refractive index 
1.6100 (estimate)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
-6.02±0.29(Predicted)
form 
Liquid or Low Melting Solid
color 
Clear yellow
Sensitive 
Moisture Sensitive
InChI
InChI=1S/C4HCl2N3O2/c5-3-2(9(10)11)1-7-4(6)8-3/h1H
InChIKey
INUSQTPGSHFGHM-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C([N+]([O-])=O)C(Cl)=N1
CAS DataBase Reference
49845-33-2(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant/Moisture Sensitive/Keep under Argon
HazardClass 
IRRITANT, LACHRYMATOR
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
658340
Product name
2,4-Dichloro-5-nitropyrimidine
Purity
97%
Packaging
10g
Price
$89.5
Updated
2025/07/31
Sigma-Aldrich
Product number
658340
Product name
2,4-Dichloro-5-nitropyrimidine
Purity
97%
Packaging
1g
Price
$28.3
Updated
2023/06/20
TCI Chemical
Product number
D3721
Product name
2,4-Dichloro-5-nitropyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$57
Updated
2025/07/31
TCI Chemical
Product number
D3721
Product name
2,4-Dichloro-5-nitropyrimidine
Purity
>98.0%(GC)
Packaging
25g
Price
$169
Updated
2025/07/31
Sigma-Aldrich
Product number
658340
Product name
2,4-Dichloro-5-nitropyrimidine
Purity
97%
Packaging
50g
Price
$753
Updated
2025/07/31
More
Less

2,4-Dichloro-5-nitropyrimidine Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

Intermediate in a solid-phase synthesis of diaminopurines.1

Uses

2,4-Dichloro-5-nitropyrimidine (cas# 49845-33-2) is a compound useful in organic synthesis.

Synthesis

611-08-5

49845-33-2

General procedure for the synthesis of 2,4-dichloro-5-nitropyrimidine from 5-nitropyrimidine-2,4(1H,3H)-dione: 5-nitrouracil (6.28 g, 0.040 mol) was mixed with phosphorus triclosan (26 mL), and N,N-dimethylaniline (8 mL) was slowly added under stirring conditions. The reaction mixture was then heated to 110 °C and maintained at this temperature for 8 hours. Upon completion of the reaction, the excess trichlorophosphorus was removed by distillation. The remaining mixture was ground and separated by silica gel column chromatography. Finally, the collected fractions were concentrated to give 6.2 g of yellow oily liquid product in 94% yield.

References

[1] Patent: CN106432239, 2017, A. Location in patent: Paragraph 0066; 0071; 0072
[2] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 2, p. 321 - 328
[3] Tetrahedron Letters, 2006, vol. 47, # 50, p. 8897 - 8900
[4] Patent: WO2010/83645, 2010, A1. Location in patent: Page/Page column 27
[5] Patent: US7256196, 2007, B1. Location in patent: Page/Page column 8; 9-10

2,4-Dichloro-5-nitropyrimidine Preparation Products And Raw materials

Raw materials

5-Nitrouracil Phosphorus oxitrichloride N,N-Diethylaniline

Preparation Products

4,5-Diaminopyrimidine
More
Less

2,4-Dichloro-5-nitropyrimidine Suppliers

Americas 1 Canada 7 China 321 Europe 2 France 1 Germany 7 India 35 Japan 2 Poland 1 Slovakia 1 Switzerland 2 The Netherlands 2 Ukraine 3 United Kingdom 19 United States 60 Global 464
Shijiazhuang Qiyue Chemical Co. LTD
Tel
15369111890
Fax
15369111890
Email
sjzqiyuekeji@163.com
Country
China
ProdList
305
Advantage
58
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Changzhou Helios Biomedical Science and Technology Co.,LTD.
Tel
18961213068
Email
121257724@qq.com
Country
China
ProdList
493
Advantage
58
Changzhou Xinda Biotechnology Co., Ltd
Tel
0519-85519868 18915088878
Email
xiaoweng106108@163.com
Country
China
ProdList
99
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
(5)02557626880
Email
dt3@aikonchem.com
Country
China
ProdList
15493
Advantage
58
Shandong Meiao Huawei Technology Co., LTD
Tel
0531-88682301 18595278766
Email
yuhongmeng@mayowell.com
Country
China
ProdList
88
Advantage
58
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
919
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Tetranov Biopharm
Tel
13526569071
Email
sales@leadmedpharm.com
Country
China
ProdList
7892
Advantage
64
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
ChangZhou SIDU chemical Co., Ltd.
Tel
0519-81291281 18015082300
Fax
0519-81291281
Email
siduchem@hotmail.com
Country
China
ProdList
274
Advantage
62
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Changzhou Standard Chemicals Ltd.
Tel
0519-85607885 13776800733
Fax
+86 519 8552788
Email
email@standardschem.com
Country
China
ProdList
114
Advantage
62
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001 13552411790
Fax
021-33690831
Email
postmaster@tyjchem.cn
Country
China
ProdList
1542
Advantage
55
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
603
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4169
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Sinfachem Limited
Tel
025-84683399 13952017251
Fax
025-84683112
Email
sales@sinfachem.com
Country
China
ProdList
217
Advantage
56
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3583
Advantage
55
Nanjing ShengSai Chemical Co., Ltd.
Tel
025-85205967 13951876367
Fax
025-85205967
Email
shengsaichem@163.com
Country
China
ProdList
818
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Beijin Yangguang Furui Chemical co.,Ltd.
Tel
010-57495520 13521095525
Email
zhw512@foxmail.com
Country
China
ProdList
488
Advantage
55
More
Less

View Lastest Price from 2,4-Dichloro-5-nitropyrimidine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2,4-Dichloro-5-nitropyrimidine 49845-33-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-09
Dideu Industries Group Limited
Product
2,4-Dichloro-5-nitropyrimidine 49845-33-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
2,4-Dichloro-5-nitropyrimidine 49845-33-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

49845-33-2, 2,4-Dichloro-5-nitropyrimidineRelated Search:

2-Chloro-5-nitropyrimidine Dichloroethane 1,2-Dichloro-4-(chloromethyl)benzene 2',4'-Dichloroacetophenone 2,4-Dichloro-5-methylpyrimidine 2,4-Dichloro-5-fluoropyrimidine 2,4-Dichloropyrimidine 2,4-DICHLORO-5-NITROPYRIDINE Nitromethane 4,6-Dichloro-5-nitropyrimidine ,98%,4,6-DICHLORO-5-NITROPYRIMIDINE, 97+%,4,6-DICHLORO-5-NITROPYRIMIDINE 2,4-Dichloro-6-methyl-5-nitropyrimidine 2,4,6-TRICHLORO-5-NITROPYRIMIDINE Nitrobenzene 2,4,6-Trinitrotoluene 2-Methyl-4,6-dichloro-5-nitropyrimidine 2,4-DICHLORO-5-NITRO-6-(TRIFLUOROMETHYL)PYRIMIDINE ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE,2,6-dichloro-5-nitropyrimidine-4-carboxylic acid ethyl ester 2-BUTYL-4,6-DICHLORO-5-NITROPYRIMIDINE

  • 2,4-DICHLORO-5-NITROPYRIMIDINE 97%
  • Pyrimidine, 2,4-dichloro-5-nitro-
  • 2,4-Dichloro-5-nitropyrimidine ,97%
  • JR-6659, 2,4-Dichloro-5-nitropyrimidine, 97%
  • 2,4-Dichloro-5-nitro-1,3-diazine
  • 2,4-DICHLORO-5-NITROPYRIMIDINE
  • 2,4- twochloro -5-nitropyriMidine
  • 2,4-Dichloro-5-nitropyrimidine&gt
  • oro-5-nitropyrimidine
  • 2,4-Dichloro-5-nitropyrimidine ISO 9001：2015 REACH
  • 5-Nitro-2,4-Dichloro pyrimidine
  • 2,4-Dichloro-5-nitropyrimidine, 98%
  • 49845-33-2
  • 4185-33-2
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyrimidines
  • Building Blocks
  • Heterocycle-Pyrimidine series
  • Building Blocks
  • C4 to C5
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Organohalides
  • Nucleotides and Nucleosides
  • pharmacetical
  • Pyrimidine Derivertives
  • Pyrimidine series
  • APIs & Intermediate
  • Pyrimidine
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Bases & Related Reagents
  • Nucleotides
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyrimidines
  • PyrimidinesHeterocyclic Building Blocks
  • Purine
  • bc0001