2,4-Dichloro-5-methylpyrimidine

Product Name: 2,4-Dichloro-5-methylpyrimidine
CAS No.: 1780-31-0
Chemical Name: 2,4-Dichloro-5-methylpyrimidine
Synonyms: NSC 37532;Toxic,stench;2,4-Dichloro-5-;2,4-Dichloro-5-methy;Dichloro-5-MethylpyriMid;2,4-Dichloro-5-Methylpyri...;4-Dichloro-5-MethylpyriMidine;5-Methyl-2,4-dichloropyrimidine;2,4-DICHLORO-5-METHYLPYRIMIDINE;2,4-dichloro-5-methyl-pyrimidin
CBNumber: CB6130202
Molecular Formula: C5H4Cl2N2
Formula Weight: 163
MOL File: 1780-31-0.mol

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2,4-Dichloro-5-methylpyrimidine Property

Melting point:: 26-28 °C (lit.)
Boiling point:: 108-109 °C/11 mmHg (lit.)
Density: 1.39 g/mL at 25 °C (lit.)
refractive index: 1.6300 (estimate)
Flash point:: >230 °F
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in chloroform, ether, ethyl acetate and toluene
form: powder to lump to clear liquid
pka: -2.44±0.29(Predicted)
color: White or Colorless to Almost white or Almost colorless
Sensitive: Lachrymatory
InChI: InChI=1S/C5H4Cl2N2/c1-3-2-8-5(7)9-4(3)6/h2H,1H3
InChIKey: DQXNTSXKIUZJJS-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(C)C(Cl)=N1
CAS DataBase Reference: 1780-31-0(CAS DataBase Reference)
EPA Substance Registry System: Pyrimidine, 2,4-dichloro-5-methyl- (1780-31-0)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45-27
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D66182
Product name: 2,4-Dichloro-5-methylpyrimidine
Purity: 98%
Packaging: 5g
Price: $112
Updated: 2025/07/31

Sigma-Aldrich

Product number: D66182
Product name: 2,4-Dichloro-5-methylpyrimidine
Purity: 98%
Packaging: 1g
Price: $34.4
Updated: 2023/06/20

TCI Chemical

Product number: D3613
Product name: 2,4-Dichloro-5-methylpyrimidine
Purity: >98.0%(GC)
Packaging: 1g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: D3613
Product name: 2,4-Dichloro-5-methylpyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: D3613
Product name: 2,4-Dichloro-5-methylpyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $152
Updated: 2025/07/31

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2,4-Dichloro-5-methylpyrimidine Chemical Properties,Usage,Production

Chemical Properties

White to Off White Low Melting Solid

Uses

2,4-Dichloro-5-methylpyrimidine, is used in the synthesis of (2-chloro-6-methyl-pyrimidin-4-yl)-(2,3-dihydro-benzothiazol-6-yl)-amine. It can react with piperidineto produce 2-chloro-5-methyl-4-piperidin-1-yl-pyrimidine. This reaction will need solvent dioxane.

Synthesis

65-71-4

1780-31-0

General procedure for the synthesis of 2,4-dichloro-5-methylpyrimidine from 5-methyluracil: 5-methyluracil (1 g, 7.93 mmol) was added to phosphorochloridic acid (7 eq., 5 ml), and the mixture was heated and refluxed for 3 hours. After completion of the reaction, the mixture was slowly poured into ice water to quench the reaction. The organic layer was extracted with chloroform (3 x 20 ml), the organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 2,4-dichloro-5-methylpyrimidine as yellow crystals (0.62 g, 48% yield). The structure of the product was confirmed by nuclear magnetic resonance hydrogen (1H NMR, 400 MHz, CDCl3) and carbon (13C NMR, 100 MHz, CDCl3) spectra: 1H NMR δ 8.35 (s, 1H), 2.39 (s, 3H); 13C NMR δ 162.5, 160.0, 158.2, 129.1, 15.8. The data obtained were in agreement with those of literature reports (Wang et al., Molecules, 2012, 17(4), 4533-4544).

References

[1] Journal of Fluorine Chemistry, 1996, vol. 77, # 1, p. 93 - 95
[2] Patent: WO2018/151681, 2018, A1. Location in patent: Paragraph 0099
[3] Synthetic Communications, 1992, vol. 22, # 20, p. 2927 - 2934
[4] Tetrahedron Letters, 1997, vol. 38, # 7, p. 1111 - 1114
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 18, p. 2961 - 2966

2,4-Dichloro-5-methylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloro-5-methylpyrimidine Suppliers

Americas 1 Canada 5 China 312 Europe 3 Germany 4 India 13 Japan 2 Russia 1 Slovakia 1 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 19 United States 60 Global 427

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View Lastest Price from 2,4-Dichloro-5-methylpyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,4-Dichloro-5-methylpyrimidine 1780-31-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-06-04

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2,4-Dichloro-5-methylpyrimidine 1780-31-0
Price: US $100.00-50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-12

Henan Fengda Chemical Co., Ltd

Product: 2,4-Dichloro-5-methylpyrimidine 1780-31-0
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

1780-31-0, 2,4-Dichloro-5-methylpyrimidineRelated Search:

Pirimiphos-methyl 4,6-Dichloropyrimidine Fluorocytosine 2,4-Dichloropyrimidine 4-Ethyl-5-fluoro-6-hydroxypyrimidine Dichloromethylphenylsilane Dichloromethylsilane 2,4-Dichloro-5-nitropyrimidine 2-Chloro-5-chloromethylpyridine 2,4-Dichloro-5-fluoropyrimidine Dichlorodimethylsilane Dichloroacetic acid (9H-FLUOREN-9-YL)METHYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE 2,4-Dichloro-5-cyanopyrimidine 2,4,6-TRICHLORO-PYRIMIDINE-5-CARBALDEHYDE 2,4-Dichloro-5-pyrimidinecarbonyl chloride (9H-FLUOREN-9-YL)METHYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate

2,4-dichloro-5-methyl-pyrimidin

2,4-Dichloro-5-methyl-1,3-diazine

Dichloro-5-MethylpyriMid

2,4-DICHLORO-5-METHYLPYRIMIDINE

2,4-Dichloro-5-methylpyrimidine**Toxic, Stench**

Toxic,stench

PYRIMIDINE,2,4-DICHLORO-5-METHYL

2,4-Dichloro-5-

5-Methyl-2,4-dichloropyrimidine

NSC 37532

2,4-Dichloro-5-methylpyrimidine ,98%

2,4-Dichloro-5-methylpyrimidine ,97%

2,4-Dichloro-5-methy

4-Dichloro-5-MethylpyriMidine

2,4-Dichloro-5-Methylpyri...

2,4-Dichloro-5-methylpyrimidine&gt

2,4-Dichloro-5-methylpyrimidine ISO 9001：2015 REACH

1780-31-0

21780-31-0

178-31-0

C5H4Cl2N2Cl

Building Blocks

Heterocyclic Building Blocks

Pyrimidines

Halogenated Heterocycles

Heterocycle-Pyrimidine series

C4 to C5

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

pharmacetical

Nucleic acids

Bases & Related Reagents

Nucleotides

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

PyrimidinesHeterocyclic Building Blocks

Halides

Heterocycles

Pyrimidine

Building Blocks

Halogenated

Nucleotides and Nucleosides

Pyrimidines