2,4-Dichloro-5-pyrimidinecarbonyl chloride
- Product Name
- 2,4-Dichloro-5-pyrimidinecarbonyl chloride
- CAS No.
- 2972-52-3
- Chemical Name
- 2,4-Dichloro-5-pyrimidinecarbonyl chloride
- Synonyms
- 2,4-Dichloropyrimidine-5-carbonyl chloride;RSYY（Avanafil)-46;5-(Chlorocarbonyl)-2,4-dichlo;2,4-dichloro-5-pyrimidinyl chloride;2,4-Dichloro-5-pyrimidinecarbonylchloride;5-(Chlorocarbonyl)-2,4-dichloropyrimidine;2,3-Dichloro-5-pyrimidine carbonyl chloride;5-Pyrimidinecarbonyl chloride, 2,4-dichloro-;2,4-DichloropyriMidine-5-carbonyl chloride 97%;2,4-Dichloro-5-pyrimidinecarboxylic acid chloride
- CBNumber
- CB7956663
- Molecular Formula
- C5HCl3N2O
- Formula Weight
- 211.43
- MOL File
- 2972-52-3.mol
2,4-Dichloro-5-pyrimidinecarbonyl chloride Property
- Boiling point:
- 83 °C(Press: 0.05 Torr)
- Density
- 1.645 g/mL at 25 °C
- refractive index
- n20/D1.586
- Flash point:
- 93℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- liquid
- pka
- -5.08±0.29(Predicted)
- color
- Clear, colourless
- InChI
- InChI=1S/C5HCl3N2O/c6-3-2(4(7)11)1-9-5(8)10-3/h1H
- InChIKey
- DZTIFMWYYHCREC-UHFFFAOYSA-N
- SMILES
- C(Cl)(C1=CN=C(Cl)N=C1Cl)=O
- CAS DataBase Reference
- 2972-52-3(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 20/21/22-34
- Safety Statements
- 6-7/9-24/25-26-36/37/39-51
- RIDADR
- 3265
- WGK Germany
- 3
- HazardClass
- IRRITANT, CORROSIVE
- PackingGroup
- Ⅲ
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 728772
- Product name
- 2,4-Dichloropyrimidine-5-carbonyl chloride
- Purity
- 97%
- Packaging
- 500mg
- Price
- $74.36
- Updated
- 2025/07/31
- Product number
- 270845
- Product name
- 2,3-Dichloro-5-pyrimidine carbonyl chloride
- Packaging
- 1g
- Price
- $433
- Updated
- 2021/12/16
- Product number
- 4H16-5-Y1
- Product name
- 2,4-Dichloropyrimidine-5-carbonyl chloride
- Packaging
- 250mg
- Price
- $64
- Updated
- 2021/12/16
- Product number
- 032528
- Product name
- 2,4-Dichloropyrimidine-5-carbonyl chloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $103
- Updated
- 2021/12/16
- Product number
- FD08253
- Product name
- 2,3-Dichloro-5-pyrimidine carbonyl chloride
- Packaging
- 1g
- Price
- $131.3
- Updated
- 2021/12/16
2,4-Dichloro-5-pyrimidinecarbonyl chloride Chemical Properties,Usage,Production
Synthesis
23945-44-0
2972-52-3
The general procedure for the synthesis of 2,4-dichloro-5-pyrimidinecarbonyl chloride from uracil-5-carboxylic acid is as follows: 9.1 Preparation of 2,4-dihydroxypyrimidine-5-carbonyl chloride In a 250 mL round bottom flask, 10.0 g (64.0 mmol) of 2,4-dihydroxypyrimidine-5-carboxylic acid was dissolved in 46 mL (500.0 mmol) of phosphorus oxychloride (POCl3) under nitrogen protection. The reaction mixture was cooled to 0°C via an ice bath, followed by the batch addition of 47.7 g (230 mmol) phosphorus pentachloride (PCl5). The reaction solution was heated and stirred at reflux for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in 100 mL of toluene and ground, followed by filtration. After this operation was repeated three times, the filtrate was evaporated under reduced pressure to give 13.5 g (64.0 mmol) of the yellow oily product 2,4-dichloro-5-pyrimidinecarbonyl chloride, which was used directly in the next step of the reaction. Yield = 100%.
References
[1] Patent: US2011/251194, 2011, A1. Location in patent: Page/Page column 21
[2] Patent: US2010/222319, 2010, A1. Location in patent: Page/Page column 18
[3] Patent: WO2015/21149, 2015, A1. Location in patent: Page/Page column 56; 57
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 6, p. 2746 - 2763
[5] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 55
2,4-Dichloro-5-pyrimidinecarbonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-Dichloro-5-pyrimidinecarbonyl chloride Suppliers
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 10-61256048 13810278579
- Fax
- +86 10 61256049
- sales@zeroschem.com
- Country
- China
- ProdList
- 1371
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 86-25-57062118
- Fax
- 86-25-57065896
- sales@jspsn.com
- Country
- China
- ProdList
- 496
- Advantage
- 57
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
View Lastest Price from 2,4-Dichloro-5-pyrimidinecarbonyl chloride manufacturers
- Product
- 2,4-Dichloro-5-pyrimidinecarbonyl chloride 2972-52-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-30