2-Fluorobenzoyl chloride
- Product Name
- 2-Fluorobenzoyl chloride
- CAS No.
- 393-52-2
- Chemical Name
- 2-Fluorobenzoyl chloride
- Synonyms
- O-FLUOROBENZOYL CHLORIDE;SKL751;NSC 88304;uorobenzoyL;2-Fluorobenzoyl;o-Fluorobenzoyl;AKOS BBS-00003920;Ataluren impurity D;2-Fluorobenzoyl chlo;2-Fluorbenzoylchlorid
- CBNumber
- CB2482497
- Molecular Formula
- C7H4ClFO
- Formula Weight
- 158.56
- MOL File
- 393-52-2.mol
2-Fluorobenzoyl chloride Property
- Melting point:
- 4 °C (lit.)
- Boiling point:
- 90-92 °C/15 mmHg (lit.)
- Density
- 1.328 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.536(lit.)
- Flash point:
- 180 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly)
- form
- Liquid
- Specific Gravity
- 1.328
- color
- Clear colorless to faintly colored
- Water Solubility
- Decomposition
- Sensitive
- Lachrymatory
- BRN
- 636864
- CAS DataBase Reference
- 393-52-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzoyl chloride, 2-fluoro-(393-52-2)
- EPA Substance Registry System
- o-Fluorobenzoyl chloride (393-52-2)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-37-36/37-14
- Safety Statements
- 26-36/37/39-45-28A-27
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- RTECS
- DM6640000
- F
- 10-19-21
- Hazard Note
- Corrosive/Lachrymatory
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29163900
- Hazardous Substances Data
- 393-52-2(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 120847
- Product name
- 2-Fluorobenzoyl chloride
- Purity
- 99%
- Packaging
- 25g
- Price
- $37.7
- Updated
- 2025/07/31
- Product number
- 120847
- Product name
- 2-Fluorobenzoyl chloride
- Purity
- 99%
- Packaging
- 100g
- Price
- $83.8
- Updated
- 2025/07/31
- Product number
- F0195
- Product name
- 2-Fluorobenzoyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- F0195
- Product name
- 2-Fluorobenzoyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 100g
- Price
- $51
- Updated
- 2025/07/31
- Product number
- F0195
- Product name
- 2-Fluorobenzoyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 500g
- Price
- $152
- Updated
- 2025/07/31
2-Fluorobenzoyl chloride Chemical Properties,Usage,Production
Chemical Properties
clear colorless to faintly colored liquid
Uses
2-Fluorobenzoyl Chloride (cas# 393-52-2) is a compound useful in organic synthesis.
Uses
2-Fluorobenzoyl chloride has been used in the preparation of 3-(N-Hydroxycarbamimidoyl)-benzoic acid methyl ester. It has been used to develop an hollow-fiber liquid phase microextraction with in situ derivatization method coupled with HPLC-UV for the determination of metformin hydrochloride in biological fluids.
General Description
Colorless liquid.
Air & Water Reactions
Decomposes in water to form HCl with generation of heat
Reactivity Profile
2-Fluorobenzoyl chloride is sensitive to moisture. Incompatible with water, alcohol, bases (including amines) and with oxidizing agents . May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Fire Hazard
2-Fluorobenzoyl chloride is combustible.
Synthesis
445-29-4
393-52-2
Step I Synthesis of 2-fluorobenzoyl chloride (intermediate a): 0.714 mol (100 g) of 2-fluorobenzoic acid was added to 100 mL of toluene, and the mixture was heated to 50 °C before 5.7 mol (414 mL) of sulfoxide chloride was added slowly. The reaction mixture was reacted under reflux conditions for 7 hours. Upon completion of the reaction, the excess sulfoxide chloride was removed by evaporation to give 79 g of 2-fluorobenzoyl chloride in 70% yield.
References
[1] Phosphorus, Sulfur and Silicon and Related Elements, 1996, vol. 113, # 1-4, p. 179 - 207
[2] Journal of Organometallic Chemistry, 2005, vol. 690, # 17, p. 3918 - 3928
[3] Organic and Biomolecular Chemistry, 2009, vol. 7, # 23, p. 4886 - 4894
[4] Patent: EP2799437, 2014, A1. Location in patent: Paragraph 0055
[5] Patent: US2014/364431, 2014, A1. Location in patent: Paragraph 0186
2-Fluorobenzoyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluorobenzoyl chloride manufacturers
- Product
- 2-Fluorobenzoyl chloride 393-52-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-01
- Product
- 2-Fluorobenzoyl chloride 393-52-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-26
- Product
- 2-Fluorobenzoyl Chloride 393-52-2
- Price
- US $10.70/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-20