5-Pyrimidinecarboxaldehyde, 2,4-dichloro-
- Product Name
- 5-Pyrimidinecarboxaldehyde, 2,4-dichloro-
- CAS No.
- 871254-61-4
- Chemical Name
- 5-Pyrimidinecarboxaldehyde, 2,4-dichloro-
- Synonyms
- 2,4-DichloropyriMidine-5-...;2,4-Dichloro-5-pyrimidinecarbaldehyde;2,4-Dichloropyrimidine-5-Carboxaldehyde;2,4-Dichloro-5-pyriMidinecarboxaldehyde;5-Pyrimidinecarboxaldehyde, 2,4-dichloro-;2,4-dichloropyrimidine-5-carbaldehyde oxime;5-Pyrimidinecarboxaldehyde, 2,4-dichloro- ISO 9001：2015 REACH
- CBNumber
- CB62130141
- Molecular Formula
- C5H2Cl2N2O
- Formula Weight
- 176.99
- MOL File
- 871254-61-4.mol
5-Pyrimidinecarboxaldehyde, 2,4-dichloro- Property
- Boiling point:
- 294.0±20.0 °C(Predicted)
- Density
- 1.588±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -4.44±0.29(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C5H2Cl2N2O/c6-4-3(2-10)1-8-5(7)9-4/h1-2H
- InChIKey
- MTIXQNKVUJSOQH-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(C=O)C(Cl)=N1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D436285
- Product name
- 2,4-Dichloro-5-pyrimidinecarboxaldehyde
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- D436285
- Product name
- 2,4-Dichloro-5-pyrimidinecarboxaldehyde
- Packaging
- 10g
- Price
- $1470
- Updated
- 2021/12/16
- Product number
- CS-D0296
- Product name
- 2,4-Dichloropyrimidine-5-carbaldehyde
- Purity
- 99.93%
- Packaging
- 250mg
- Price
- $36
- Updated
- 2021/12/16
- Product number
- FD140227
- Product name
- 2,4-Dichloropyrimidine-5-carbaldehyde
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- OR959527
- Product name
- 2,4-Dichloropyrimidine-5-carbaldehyde
- Purity
- 98%
- Packaging
- 250mg
- Price
- $58
- Updated
- 2021/12/16
5-Pyrimidinecarboxaldehyde, 2,4-dichloro- Chemical Properties,Usage,Production
Uses
2,4-Dichloro-5-pyrimidinecarboxaldehyde, is an organic building block used for the synthesis of novel pyrazolo[3,4-d]pyrimidine compounds, as possible kinase inhibitors.
Synthesis
4394-85-8
36082-50-5
871254-61-4
General procedure for the preparation of 2,4-dichloropyrimidine-5-carbaldehyde: In a 2L round-bottomed flask, a solution of isopropylmagnesium chloride lithium chloride complex in THF (2M, 184mL, 368mmol) was added dropwise to a solution of 5-bromo-2,4-dichloropyrimidine (49.6g, 218mmol) in THF (1000mL) over a period of ~30 minutes at ~-78 °C (1000 mL). The reaction mixture was stirred at about -78 °C for about 30 minutes. Subsequently, morpholine-4-carbaldehyde (75.0 g, 653 mmol) was added dropwise over about 30 minutes at the same temperature. After continuing to stir at about -78°C for about 30 minutes, the reaction mixture was slowly warmed to about -35°C and stirred at this temperature for about 30 minutes. Upon completion of the reaction, 1N HCl aqueous solution (250 mL) and ether (500 mL) were added and the mixture was then warmed to room temperature. The organic layer was separated and the aqueous layer was further extracted with ether (200 mL). The combined organic layers were dried with anhydrous MgSO4, filtered through a silica gel pad and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using dichloromethane (100%) as eluent to afford 2,4-dichloropyrimidine-5-carbaldehyde (27.3 g, 71% yield) as a light yellow solid.1H NMR (400 MHz, CDCl3) δ 10.34 (s, 1H), 9.30 (s, 1H).
References
[1] Patent: WO2011/156698, 2011, A2. Location in patent: Page/Page column 52
5-Pyrimidinecarboxaldehyde, 2,4-dichloro- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Pyrimidinecarboxaldehyde, 2,4-dichloro- manufacturers
- Product
- 2,4-dichloropyrimidine-5-carbaldehyde 871254-61-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-19
- Product
- 5-Pyrimidinecarboxaldehyde, 2,4-dichloro- 871254-61-4
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 95%-98%
- Supply Ability
- 100
- Release date
- 2019-09-04