ethyl 2,4-dichloropyrimidine-5-carboxylate
- Product Name
- ethyl 2,4-dichloropyrimidine-5-carboxylate
- CAS No.
- 51940-64-8
- Chemical Name
- ethyl 2,4-dichloropyrimidine-5-carboxylate
- Synonyms
- 2,4-dichloropyriMidine-5-carboxylate;Ethyl 2,4-dic;5-PyriMidinecar;2,4-Dichloro-5-pyriMidine;2,4-Dichloro-5-carbethoxypyrimidine;Ethyl 2,4-Dichloro-5-pyrimidinecarboxylate;ethyl 2,4-dichloropyrimidine-5-carboxylate;Ethyl 2,4-dichloropyrimidine-5-carboxylate 98%;Ethyl 2,4-dichloro-5 pyrimidine carboxylic acid;2,4-Dichloropyrimidine-5-carboxylic acid ethyl ester
- CBNumber
- CB5908491
- Molecular Formula
- C7H6Cl2N2O2
- Formula Weight
- 221.04
- MOL File
- 51940-64-8.mol
ethyl 2,4-dichloropyrimidine-5-carboxylate Property
- Melting point:
- 36-37℃
- Boiling point:
- 145°C/11mmHg(lit.)
- Density
- 1.433
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- -4.47±0.29(Predicted)
- form
- Powder
- color
- White
- Water Solubility
- Slightly soluble in water.
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C7H6Cl2N2O2/c1-2-13-6(12)4-3-10-7(9)11-5(4)8/h3H,2H2,1H3
- InChIKey
- SRJBDGLSCPDXBL-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(C(OCC)=O)C(Cl)=N1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- E1154
- Product name
- Ethyl 2,4-Dichloropyrimidine-5-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $90
- Updated
- 2025/07/31
- Product number
- E1154
- Product name
- Ethyl 2,4-Dichloropyrimidine-5-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $308
- Updated
- 2025/07/31
- Product number
- E915893
- Product name
- Ethyl 2,4-Dichloropyrimidine-5-carboxylate
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 071103
- Product name
- Ethyl 2,4-dichloropyrimidine-5-carboxylate
- Purity
- 97%
- Packaging
- 25g
- Price
- $279
- Updated
- 2021/12/16
- Product number
- HCH0142090
- Product name
- 2,4-DICHLOROPYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
- Purity
- 98.00%
- Packaging
- 5G
- Price
- $1428.74
- Updated
- 2021/12/16
ethyl 2,4-dichloropyrimidine-5-carboxylate Chemical Properties,Usage,Production
Uses
It's employed as an important intermediate for raw material for organic synthesis, agrochemical, pharmaceutical and dyestuff field
Synthesis Reference(s)
Journal of the American Chemical Society, 64, p. 794, 1942 DOI: 10.1021/ja01256a016
Synthesis
28485-17-8
51940-64-8
General procedure for the synthesis of ethyl 2,4-dichloro-5-pyrimidinecarboxylate from ethyl 4-hydroxy-2-oxopyrimidine-5-carboxylate: a mixture of 5-carboxyuracil (3.01 g, 16.34 mmol), POCl3 (27 mL), and N,N-diethylaniline (4.5 mL) was stirred and refluxed for 2 hr until 5-carboxyuracil was completely consumed. The reaction mixture was cooled to room temperature and then slowly poured into ice water (50 mL) and extracted with ether (2 x 100 mL). The combined ether layers were washed sequentially with saturated sodium bicarbonate solution and brine. After drying with anhydrous sodium sulfate, it was concentrated under reduced pressure to give the target product ethyl 2,4-dichloro-5-pyrimidinecarboxylate as a brown liquid in quantitative yield (3.6 g).LRMS (M+H+) m/z 221.0.
References
[1] Patent: US2009/198057, 2009, A1. Location in patent: Page/Page column 18
[2] Patent: US2006/160817, 2006, A1. Location in patent: Page/Page column 83-84
[3] Patent: US2009/264401, 2009, A1. Location in patent: Page/Page column 47
[4] Patent: CN104650045, 2017, B. Location in patent: Paragraph 0058-0060
[5] Patent: WO2011/19405, 2011, A1. Location in patent: Page/Page column 119
ethyl 2,4-dichloropyrimidine-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ethyl 2,4-dichloropyrimidine-5-carboxylate manufacturers
- Product
- ethyl 2,4-dichloropyrimidine-5-carboxylate 51940-64-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- Ethyl 2,4-dichloropyrimidine-5-carboxylate 51940-64-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Ethyl 2,4-dichloropyrimidine-5-carboxylate 51940-64-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08