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4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER

Product Name
4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
CAS No.
41103-17-7
Chemical Name
4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
Synonyms
ETHYL 4-CHLOROPYRIMIDINE-5-CARBOXYLATE;4-Chloropyrimidin-5-carboxylic acid ethyl ester;4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER;5-Pyrimidinecarboxylic acid, 4-chloro-, ethyl ester;4-chloro-5-Pyrimidinecarboxylic acid ethyl ester (7CI 9CI ACI);5-Pyrimidinecarboxylic acid, 4-chloro-, ethyl ester (7CI, 9CI, ACI)
CBNumber
CB5252082
Molecular Formula
C7H7ClN2O2
Formula Weight
186.6
MOL File
41103-17-7.mol
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4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Property

Boiling point:
278.2±20.0 °C(Predicted)
Density 
1.311±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
-1.62±0.16(Predicted)
form 
semi-solid
color 
Yellow
InChI
InChI=1S/C7H7ClN2O2/c1-2-12-7(11)5-3-9-4-10-6(5)8/h3-4H,2H2,1H3
InChIKey
AZJAMMCCAZZXIK-UHFFFAOYSA-N
SMILES
C1=NC=C(C(OCC)=O)C(Cl)=N1
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
E903455
Product name
Ethyl4-Chloro-5-pyrimidinecarboxylate
Packaging
1g
Price
$120
Updated
2021/12/16
TRC
Product number
E903455
Product name
Ethyl4-Chloro-5-pyrimidinecarboxylate
Packaging
25g
Price
$1935
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0316593
Product name
ETHYL-4-CHLORO-5-PYRIMIDINE CARBOXYLATE
Purity
98.00%
Packaging
5G
Price
$2067.45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0316593
Product name
ETHYL-4-CHLORO-5-PYRIMIDINE CARBOXYLATE
Purity
98.00%
Packaging
10G
Price
$2924.46
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0316593
Product name
ETHYL-4-CHLORO-5-PYRIMIDINE CARBOXYLATE
Purity
98.00%
Packaging
1G
Price
$1034.88
Updated
2021/12/16
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4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Uses

Ethyl 4-Chloro-5-pyrimidinecarboxylate is a reagent used in the synthesis of a series of novel orally active non-peptide angiotensin II antagonists.

Synthesis

4786-52-1

41103-17-7

Ethyl 4-hydroxy-5-pyrimidinecarboxylate (380 mg, 2.26 mmol) was dissolved in tetrahydrofuran (THF, 5 mL) and thionyl chloride (1.65 mL, 22.6 mmol) was added slowly. The reaction mixture was heated to reflux and kept for 4 hours. Upon completion of the reaction, the reaction solution was concentrated by rotary evaporator under reduced pressure to give 417 mg (99% yield) of ethyl 4-chloropyrimidine-5-carboxylate as crude product. The crude product could be used directly in the subsequent reaction without further purification or characterization.

References

[1] Patent: WO2006/91506, 2006, A2. Location in patent: Page/Page column 40
[2] Patent: WO2006/49681, 2006, A2. Location in patent: Page/Page column 38
[3] Patent: WO2006/121588, 2006, A2. Location in patent: Page/Page column 44
[4] Patent: WO2006/121860, 2006, A2. Location in patent: Page/Page column 44
[5] Patent: WO2006/121904, 2006, A1. Location in patent: Page/Page column 44

4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Suppliers

China 131 India 3 United Kingdom 1 United States 16 Global 151
Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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SY06@accelachem.com
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China
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SiChuang NanBu Honesty Technology Co., Ltd.
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0838-5675166 15883665058
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821-50328103-801 18930552037
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025-83697070
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+86-25-83453306
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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View Lastest Price from 4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 41103-17-7
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-12
Shaanxi Dideu Medichem Co. Ltd
Product
4-Chloro-pyrimidine-5-carboxylic acid ethyl ester 41103-17-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15
Shanghai Rlavie Technology Co ltd
Product
Ethyl 4-Chloro-5-pyrimidinecarboxylate 41103-17-7
Price
US $0.00-0.00/kg
Min. Order
0.0001kg
Purity
98%min
Supply Ability
100kgs/month
Release date
2022-05-09

41103-17-7, 4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTERRelated Search:

4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 4-CHLOROPYRIMIDINE-5-CARBOXYLIC ACID Ethyl 2-chloropyrimidine-5-carboxylate Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate ethyl 2,4-dichloropyrimidine-5-carboxylate 4-Chloropyrimidine ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE ethyl 2-tert-butyl-4-chloropyrimidine-5-carboxylate ethyl 4-chloro-2-pyridin-2-ylpyrimidine-5-carboxylate 5-PYRIMIDINECARBOXYLIC ACID, 4,6-DICHLORO-,ETHYL ESTER ETHYL 4-CHLORO-2-MORPHOLINOPYRIMIDINE-5-CARBOXYLATE ethyl 4-chloro-2-cyclopropylpyrimidine-5-carboxylate ETHYL 4-CHLORO-2-PHENYL-5-PYRIMIDINECARBOXYLATE 5-CARBETHOXY-4-CHLORO-2-ETHYL-MERCAPTOPYRIMIDINE ETHYL4-CHLORO-2-(2-PYRIDYL)PYRIMIDINE-5-CARBOXYLATE ethyl 4-chloro-2-pyridin-4-ylpyrimidine-5-carboxylate ethyl 4-chloro-2-(1-methylethyl)pyrimidine-5-carboxylate

  • 4-CHLORO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
  • ETHYL 4-CHLOROPYRIMIDINE-5-CARBOXYLATE
  • 5-Pyrimidinecarboxylic acid, 4-chloro-, ethyl ester
  • 5-Pyrimidinecarboxylic acid, 4-chloro-, ethyl ester (7CI, 9CI, ACI)
  • 4-chloro-5-Pyrimidinecarboxylic acid ethyl ester (7CI 9CI ACI)
  • 4-Chloropyrimidin-5-carboxylic acid ethyl ester
  • 41103-17-7
  • Heterocycle-Pyrimidine series