2,4-Dichloropyrimidine-5-carboxylic acid
- Product Name
- 2,4-Dichloropyrimidine-5-carboxylic acid
- CAS No.
- 37131-89-8
- Chemical Name
- 2,4-Dichloropyrimidine-5-carboxylic acid
- Synonyms
- Pyrazino[2,3-f][1,12]phenanthroline;2,4-Dichloropyrimidine-5-carboxylic acid;2,4-Dichloro-5-pyrimidinecarboxylic acid;5-PyriMidinecarboxylic acid, 2,4-dichloro-
- CBNumber
- CB71503954
- Molecular Formula
- C5H2Cl2N2O2
- Formula Weight
- 192.99
- MOL File
- 37131-89-8.mol
2,4-Dichloropyrimidine-5-carboxylic acid Property
- Melting point:
- 90-97 °C
- Boiling point:
- 368.4±22.0 °C(Predicted)
- Density
- 1.718
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 0.97±0.32(Predicted)
- form
- solid
- color
- White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 753475
- Product name
- 2,4-Dichloropyrimidine-5-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $142
- Updated
- 2023/06/20
- Product number
- D437123
- Product name
- 2,4-Dichloropyrimidine-5-carboxylic acid
- Packaging
- 500mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- FD152099
- Product name
- 2,4-Dichloropyrimidine-5-carboxylic acid
- Packaging
- 2g
- Price
- $280
- Updated
- 2021/12/16
- Product number
- 055409
- Product name
- 2,4-Dichloropyrimidine-5-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $289
- Updated
- 2021/12/16
- Product number
- X2143
- Product name
- 2,4,-Dichloro-5-pyrimidinecarboxylicacid
- Packaging
- 1g
- Price
- $147
- Updated
- 2021/12/16
2,4-Dichloropyrimidine-5-carboxylic acid Chemical Properties,Usage,Production
Synthesis
23945-44-0
37131-89-8
The general procedure for the synthesis of 2,4-dichloropyrimidine-5-carboxylic acid from uracil-5-carboxylic acid was as follows: 10.0 g (64.06 mmol) of uracil-5-carboxylic acid (purchased from Aldrich Chemical Company), which was partially dissolved in 20 mL of N,N-dimethylformamide (DMF), was placed in a reaction vial under the cooling condition in an ice bath. Subsequently, 59.7 mL (0.64 mol) of phosphoryl chloride and 10.3 mL (64.7 mmol) of N,N-diethylaniline were slowly added to the reaction system. The reaction mixture was heated and refluxed in an oil bath at 90°C for 2 hours and 40 minutes. Upon completion of the reaction, the system was cooled to room temperature and the excess phosphoryl chloride was removed by distillation under reduced pressure (about half the volume was evaporated). The remaining reaction solution was slowly poured into crushed ice to quench the reaction and then extracted with ether. The organic phases were combined, dried over anhydrous sodium sulfate, filtered to remove the desiccant, and the filtrate was concentrated under reduced pressure by rotary evaporator to afford 8.1 g (41.97 mmol) of the white solid product 2,4-dichloropyrimidine-5-carboxylic acid in 65% yield.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 24, p. 6352 - 6356
[2] Patent: US2012/277220, 2012, A1. Location in patent: Page/Page column 16
[3] Journal of Organic Chemistry, 1955, vol. 20, p. 829,833,835
[4] Patent: CN104650045, 2017, B. Location in patent: Paragraph 0106; 0108
2,4-Dichloropyrimidine-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloropyrimidine-5-carboxylic acid manufacturers
- Product
- 2,4-Dichloropyrimidine-5-carboxylic acid 37131-89-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- 2,4-Dichloropyrimidine-5-carboxylic Acid 37131-89-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-09
- Product
- 2,4-Dichloropyrimidine-5-carboxylic acid 37131-89-8
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-10