Methyl2,4-Dichloropyrimidine-5-carboxylate

Product Name: Methyl2,4-Dichloropyrimidine-5-carboxylate
CAS No.: 3177-20-6
Chemical Name: Methyl2,4-Dichloropyrimidine-5-carboxylate
Synonyms: Methyl 2,4-dichloro-5-pyrimidinecarboxylate;Methyl 2,4-dichloropyrimidine-5-carboxylate 97%;Methyl 2,4-dichloropyrimidine-5-carboxylate, GC 97%;2,4-Dichloropyrimidine-5-carboxylicacid methyl ester;5-PyriMidinecarboxylic acid, 2,4-dichloro-, Methyl ester;Methyl2,4-Dichloropyrimidine-5-carboxylate ISO 9001：2015 REACH
CBNumber: CB81073573
Molecular Formula: C6H4Cl2N2O2
Formula Weight: 207.01
MOL File: 3177-20-6.mol

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Methyl2,4-Dichloropyrimidine-5-carboxylate Property

Melting point:: 30-34℃
Boiling point:: 130-135 °C(Press: 16 Torr)
Density: 1.503±0.06 g/cm3(Predicted)
Flash point:: 110℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: -4.55±0.29(Predicted)
color: White to yellow
InChI: InChI=1S/C6H4Cl2N2O2/c1-12-5(11)3-2-9-6(8)10-4(3)7/h2H,1H3
InChIKey: FNNAWVXVOHNOFF-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(C(OC)=O)C(Cl)=N1

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Safety

Hazard Codes: Xn
Risk Statements: 26-36/37/38-22
Safety Statements: 26-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 716596
Product name: Methyl 2,4-dichloropyrimidine-5-carboxylate
Purity: 97%
Packaging: 1g
Price: $56.1
Updated: 2023/06/20

TRC

Product number: M301408
Product name: Methyl 2,4-dichloropyrimidine-5-carboxylate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: M301408
Product name: Methyl 2,4-dichloropyrimidine-5-carboxylate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 057924
Product name: Methyl 2,4-dichloropyrimidine-5-carboxylate
Purity: 95%
Packaging: 1g
Price: $121
Updated: 2021/12/16

AK Scientific

Product number: W5368
Product name: Methyl2,4-dichloro-5-pyrimidinecarboxylate
Packaging: 5g
Price: $157
Updated: 2021/12/16

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Methyl2,4-Dichloropyrimidine-5-carboxylate Chemical Properties,Usage,Production

Synthesis

67-56-1

2972-52-3

3177-20-6

Methanol (87.6 mg, 2.73 mmol) and diisopropylethylamine (369 mg, 2.86 mmol) were slowly added to a solution of 2,4-dichloropyrimidine-5-carbocarbonyl chloride (500 mg, 2.38 mmol) in methylene chloride (30 mL) at 0 °C. The reaction mixture was stirred continuously at 0 °C for 1 hour. After completion of the reaction, the solvent was removed by rotary evaporator. The obtained residue (461 mg, 94% yield) was dissolved in isopropanol (20 mL), followed by dropwise addition of trans-4-aminocyclohexanol (301.6 mg, 2.62 mmol) and diisopropylethylamine (461.4 mg, 3.57 mmol). The reaction mixture was continued to be stirred at 0 °C for 90 min. Next, n-butylamine (208.8 mg, 2.86 mmol) and diisopropylethylamine (461.4 mg, 3.57 mmol) were added and the mixture was stirred at room temperature for 3 hours. At the end of the reaction, the reaction was quenched by the addition of water. The reaction mixture was extracted with ethyl acetate (3 x 30 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated. The residue was purified by an ISCO automated fast chromatography system to afford methyl 2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxylate (682.6 mg, three-step overall yield 89%).1H NMR (400 MHz, CDCl3) δ 9.21 (s, 1H), 8.77 (s, 1H), 6.29 (s, 1H) 4.81-4.64 (m, 1H), 4.51 (s, 3H), 4.46-4.38 (m, 1H), 4.13-4.11 (m, 2H), 2.89-2.81 (m, 2H), 2.74 (d, J=9.7 Hz, 2H), 2.35-2.25 (m, 2H), 2.23-2.00 (m, 6H), 1.67 (t, J=7.2Hz, 3H); 13C NMR (101MHz, CDCl3) δ 167.9, 162.5, 161.3, 160.3, 95.5, 69.7, 51.2, 48.3, 41.1, 33.8, 31.7, 30.3, 20.1, 13.8; MS m/z 323.20 [M+H]+.

References

[1] Patent: WO2013/177168, 2013, A1. Location in patent: Page/Page column 34; 35
[2] Patent: WO2014/85225, 2014, A1. Location in patent: Page/Page column 18; 19; 28; 29
[3] Patent: WO2015/157127, 2015, A1. Location in patent: Page/Page column 167
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 16, p. 4857 - 4859
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4642 - 4646

Methyl2,4-Dichloropyrimidine-5-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl2,4-Dichloropyrimidine-5-carboxylate Suppliers

China 135 Europe 1 France 1 Germany 2 India 2 Ukraine 1 United Kingdom 3 United States 13 Global 158

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View Lastest Price from Methyl2,4-Dichloropyrimidine-5-carboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Methyl2,4-Dichloropyrimidine-5-carboxylate 3177-20-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methyl2,4-Dichloropyrimidine-5-carboxylate 3177-20-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methyl2,4-Dichloropyrimidine-5-carboxylate 3177-20-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

3177-20-6, Methyl2,4-Dichloropyrimidine-5-carboxylateRelated Search:

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5-PyriMidinecarboxylic acid, 2,4-dichloro-, Methyl ester

Methyl 2,4-dichloropyrimidine-5-carboxylate 97%

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Methyl2,4-Dichloropyrimidine-5-carboxylate ISO 9001：2015 REACH

3177-20-6

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