2-Chloro-4,6-dimethoxypyrimidine

Product Name: 2-Chloro-4,6-dimethoxypyrimidine
CAS No.: 13223-25-1
Chemical Name: 2-Chloro-4,6-dimethoxypyrimidine
Synonyms: 4-methoxybenzoicacidsodium;oro-4,6-dimethoxypyrimidine;2-CHLOR-4,6-DIMETHOXYPYRIMIDINE;-Chloro-4,6-dimethoxypyrimidine;4,6-diMethoxypyriMidine-2-chloro;2-CHLORO-4,6-DIMETHOXYPYRIMIDINE;PYRIMIDINE, 2-CHLORO-4,6-DIMETHOXY-;2-Chloro-4,6-dimethoxypyrimidine >2-CHLORO-4,6-DIMETHOXYPYRIMIDINE 98+%;2-Chloro-4,6-dimethoxypyrimidine >=98.0%
CBNumber: CB0773616
Molecular Formula: C6H7ClN2O2
Formula Weight: 174.59
MOL File: 13223-25-1.mol

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2-Chloro-4,6-dimethoxypyrimidine Property

Melting point:: 100-105 °C
Boiling point:: 317.1±22.0 °C(Predicted)
Density: 1.285±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: -1.46±0.30(Predicted)
color: White to Light yellow
BRN: 880035
InChIKey: PBEKEFWBLFBSGQ-UHFFFAOYSA-N
CAS DataBase Reference: 13223-25-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36-36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C1433
Product name: 2-Chloro-4,6-dimethoxypyrimidine
Purity: >98.0%(GC)
Packaging: 10g
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: C1433
Product name: 2-Chloro-4,6-dimethoxypyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $91
Updated: 2025/07/31

TRC

Product number: C379120
Product name: 2-Chloro-4,6-dimethoxypyrimidine
Packaging: 5g
Price: $55
Updated: 2021/12/16

Chem-Impex

Product number: 44834
Product name: 2-Chloro-4,6-dimethoxypyrimidine,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 10G
Price: $61.17
Updated: 2021/12/16

Matrix Scientific

Product number: 073560
Product name: 2-Chloro-4,6-dimethoxypyrimidine
Purity: 95+%
Packaging: 10g
Price: $82
Updated: 2021/12/16

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2-Chloro-4,6-dimethoxypyrimidine Chemical Properties,Usage,Production

Chemical Properties

White Powder

Uses

2-Chloro-4,6-dimethoxypyrimidine is used as building block in chemical synthesis. Product Data Sheet

Uses

2-Chloro-4,6-dimethoxypyrimidine is a useful reactant for the synthesis of polycyclic fused and spiro-?4-?aminopyridines

Synthesis

36315-01-2

13223-25-1

General procedure for the synthesis of 2-chloro-4,6-dimethoxypyrimidine from 2-amino-4,6-dimethoxypyrimidine: 1. 1,260 ml of 36% hydrochloric acid was added to a 5-liter four-necked flask and subsequently cooled to 0°C. 2. 180 g (1.16 moles) of 2-amino-4,6-dimethoxypyrimidine was added to the flask in batches and stirred continuously for about 1 hour until the reaction mixture took on a syrupy consistency. 3. After the reaction mixture was further cooled to -15°C, 260 ml of an aqueous solution containing 159 g (2.3 moles) of NaNO2 was slowly added dropwise over a period of about 1 hour under vigorous stirring. 4. after completion of the dropwise addition, the mixture was continued to be stirred at -15°C to -10°C for 1 hour to ensure complete reaction. 5. While keeping the reaction mixture at -5°C, 1.5 liters of 30% aqueous NaOH was slowly added dropwise to adjust the pH to 7 for neutralization. 6. The resulting purple clay-like substance was collected by filtration under reduced pressure. 7. the target compound 2-chloro-4,6-dimethoxypyrimidine was extracted from the clay-like material using 3 liters of ethyl acetate. 8. The organic layer was washed with water, dried over anhydrous sodium sulfate, and the solvent was removed to yield 63 g of light blue crude crystals. 9. Purification and crystallization by silica gel chromatography resulted in 60.8 g of white crystals (yield: 29.9%) with a melting point of 101.5°-102.5°C. The final product was purified by silica gel chromatography.

References

[1] Patent: US4986846, 1991, A
[2] Pesticide Science, 1996, vol. 47, # 2, p. 103 - 114

2-Chloro-4,6-dimethoxypyrimidine Preparation Products And Raw materials

Raw materials

Malononitrile Dispersing agent

Preparation Products

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2-Chloro-4,6-dimethoxypyrimidine Suppliers

Americas 1 Belgium 1 Brazil 1 China 237 Europe 3 France 1 Germany 5 India 7 Japan 3 Slovakia 1 Switzerland 3 Ukraine 1 United Kingdom 14 United States 41 Global 319

J & K SCIENTIFIC LTD.

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View Lastest Price from 2-Chloro-4,6-dimethoxypyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-4,6-dimethoxypyrimidine 13223-25-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Chloro-4,6-dimethoxypyrimidine 13223-25-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 2-Chloro-4,6-dimethoxypyrimidine 13223-25-1
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100g , 1kg, 5kg , 50kg
Release date: 2020-01-07

13223-25-1, 2-Chloro-4,6-dimethoxypyrimidineRelated Search:

Dimethoxymethane 2,6-Dimethoxybenzaldehyde Diphenyldimethoxysilane 1,1-Dimethoxyethane Dimethyldimethoxysilane Difluorochloromethane 2-CHLORO-4-METHOXYPYRIMIDINE 4-CHLORO-2,6-DIMETHOXYPYRIMIDINE,6-CHLORO-2,4-DIMETHOXYPYRIMIDINE,6-CHLORO-2,4-DIMETHOXYPYRIMIDINE, 98+% 4,6-Dimethoxypyrimidine 4(1H)-Pyrimidinone, 2-chloro- (9CI) 2-CHLORO-4,6-DIMETHOXY-5-NITRO-PYRIMIDINE 2-CHLORO-4,6-DIMETHOXY-5-PYRIMIDINAMINE 2-Chloro-4,6-dimethoxypyrimidine 4-Chloro-2,6-dimethoxypyrimidine-5-carbaldehyde 6-Chloro-2,4-dimethoxypyrimidine-5-propenoic acid methyl ester 5-CHLORO-4,6-DIMETHOXYPYRIMIDINE

2-CHLORO-4,6-DIMETHOXYPYRIMIDINE

4-methoxybenzoicacidsodium

PYRIMIDINE, 2-CHLORO-4,6-DIMETHOXY-

2-CHLOR-4,6-DIMETHOXYPYRIMIDINE

2-CHLORO-4,6-DIMETHOXYPYRIMIDINE 98+%

4,6-diMethoxypyriMidine-2-chloro

2-Chloro-4,6-dimethoxypyrimidine >=98.0%

2-Chloro-4,6-dimethoxypyrimidine &gt

oro-4,6-dimethoxypyrimidine

2-Chloro-4,6-dimethoxypyrimidine ISO 9001：2015 REACH

2-Chloro-4,6-dimethoxypyrimidine/ 13223-25-1

-Chloro-4,6-dimethoxypyrimidine

13223-25-1

1851-48-9

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