ChemicalBook > CAS DataBase List > 2-Chloro-4,6-dimethoxypyrimidine

2-Chloro-4,6-dimethoxypyrimidine

Product Name
2-Chloro-4,6-dimethoxypyrimidine
CAS No.
13223-25-1
Chemical Name
2-Chloro-4,6-dimethoxypyrimidine
Synonyms
4-methoxybenzoicacidsodium;oro-4,6-dimethoxypyrimidine;2-CHLOR-4,6-DIMETHOXYPYRIMIDINE;-Chloro-4,6-dimethoxypyrimidine;4,6-diMethoxypyriMidine-2-chloro;2-CHLORO-4,6-DIMETHOXYPYRIMIDINE;PYRIMIDINE, 2-CHLORO-4,6-DIMETHOXY-;2-Chloro-4,6-dimethoxypyrimidine >2-CHLORO-4,6-DIMETHOXYPYRIMIDINE 98+%;2-Chloro-4,6-dimethoxypyrimidine >=98.0%
CBNumber
CB0773616
Molecular Formula
C6H7ClN2O2
Formula Weight
174.59
MOL File
13223-25-1.mol
More
Less

2-Chloro-4,6-dimethoxypyrimidine Property

Melting point:
100-105 °C
Boiling point:
317.1±22.0 °C(Predicted)
Density 
1.285±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
-1.46±0.30(Predicted)
color 
White to Light yellow
BRN 
880035
InChIKey
PBEKEFWBLFBSGQ-UHFFFAOYSA-N
CAS DataBase Reference
13223-25-1(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36-36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
C1433
Product name
2-Chloro-4,6-dimethoxypyrimidine
Purity
>98.0%(GC)
Packaging
10g
Price
$47
Updated
2025/07/31
TCI Chemical
Product number
C1433
Product name
2-Chloro-4,6-dimethoxypyrimidine
Purity
>98.0%(GC)
Packaging
25g
Price
$91
Updated
2025/07/31
TRC
Product number
C379120
Product name
2-Chloro-4,6-dimethoxypyrimidine
Packaging
5g
Price
$55
Updated
2021/12/16
AK Scientific
Product number
J52728
Product name
2-Chloro-4,6-dimethoxypyrimidine
Packaging
25g
Price
$38
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC12024
Product name
2-Chloro-4,6-dimethoxypyrimidine
Packaging
10g
Price
$50
Updated
2021/12/16
More
Less

2-Chloro-4,6-dimethoxypyrimidine Chemical Properties,Usage,Production

Chemical Properties

White Powder

Uses

2-Chloro-4,6-dimethoxypyrimidine is used as building block in chemical synthesis. Product Data Sheet

Uses

2-Chloro-4,6-dimethoxypyrimidine is a useful reactant for the synthesis of polycyclic fused and spiro-?4-?aminopyridines

Synthesis

36315-01-2

13223-25-1

General procedure for the synthesis of 2-chloro-4,6-dimethoxypyrimidine from 2-amino-4,6-dimethoxypyrimidine: 1. 1,260 ml of 36% hydrochloric acid was added to a 5-liter four-necked flask and subsequently cooled to 0°C. 2. 180 g (1.16 moles) of 2-amino-4,6-dimethoxypyrimidine was added to the flask in batches and stirred continuously for about 1 hour until the reaction mixture took on a syrupy consistency. 3. After the reaction mixture was further cooled to -15°C, 260 ml of an aqueous solution containing 159 g (2.3 moles) of NaNO2 was slowly added dropwise over a period of about 1 hour under vigorous stirring. 4. after completion of the dropwise addition, the mixture was continued to be stirred at -15°C to -10°C for 1 hour to ensure complete reaction. 5. While keeping the reaction mixture at -5°C, 1.5 liters of 30% aqueous NaOH was slowly added dropwise to adjust the pH to 7 for neutralization. 6. The resulting purple clay-like substance was collected by filtration under reduced pressure. 7. the target compound 2-chloro-4,6-dimethoxypyrimidine was extracted from the clay-like material using 3 liters of ethyl acetate. 8. The organic layer was washed with water, dried over anhydrous sodium sulfate, and the solvent was removed to yield 63 g of light blue crude crystals. 9. Purification and crystallization by silica gel chromatography resulted in 60.8 g of white crystals (yield: 29.9%) with a melting point of 101.5°-102.5°C. The final product was purified by silica gel chromatography.

References

[1] Patent: US4986846, 1991, A
[2] Pesticide Science, 1996, vol. 47, # 2, p. 103 - 114

2-Chloro-4,6-dimethoxypyrimidine Preparation Products And Raw materials

Raw materials

Malononitrile Dispersing agent

Preparation Products

More
Less

2-Chloro-4,6-dimethoxypyrimidine Suppliers

Americas 1 Belgium 1 Brazil 1 China 237 Europe 3 France 1 Germany 5 India 7 Japan 3 Slovakia 1 Switzerland 3 Ukraine 1 United Kingdom 14 United States 41 Global 319
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527621225
Email
1791901229@qq.com
Country
China
ProdList
6945
Advantage
52
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2327
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3930
Advantage
58
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2930
Advantage
58
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Hangzhou Dechem Tech Co.，Ltd
Tel
86-0571-87649320
Fax
86-0571-87649320
Email
dechem@aliyun.com
Country
China
ProdList
162
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Shouguang Jiasheng Chemical Co., Ltd.
Tel
0536-7971999 13583611556
Fax
0536-7971999
Email
sgjiasheng@hotmail.com
Country
China
ProdList
288
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4641
Advantage
60
Beijing Holiyang Chemical Co. Ltd.
Tel
13718199399
Fax
QQ : 206661479
Email
holiyangchem@163.com
Country
China
ProdList
3280
Advantage
56
Shanghai YouPeng Chemical Co. Ltd.
Tel
021-69005955 13701776567
Fax
021-69005775
Email
youpengchem@163.com
Country
China
ProdList
4161
Advantage
56
Sichuan Hainuowei Technology Co. Ltd.
Tel
13708085536 13708085536
Fax
QQ : 121102042
Email
hanovichem@163.com
Country
China
ProdList
3282
Advantage
56
Shanghai TongYuan Chemical Co., Ltd.
Tel
021-021-69182866 13701855675
Fax
021-69182022
Email
tongyuanchem@126.com
Country
China
ProdList
4193
Advantage
58
Shanghai Kaisai Chemical Co., Ltd
Tel
021-33516722 13701817765
Fax
021-33516776
Email
kaisaichem@163.com
Country
China
ProdList
4610
Advantage
58
Beijing HuaYangZhicheng Technology Co., Ltd.
Tel
13716033033
Fax
010-56276266
Email
hanchochem@163.com
Country
China
ProdList
2960
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Shanghai LanRun Chemical Co., Ltd.
Tel
021-69515658 ; 69515628 13701998368
Fax
021-69515998
Email
longrunchem@163.com
Country
China
ProdList
3786
Advantage
50
Shanghai Rolead Chemical Technology Co., Ltd.
Tel
021-69992220 13701886816
Fax
021-69992237
Email
roleadchem@163.com
Country
China
ProdList
4613
Advantage
50
Shanghai Kangtuo Chemical Co., Ltd.
Tel
021-69185552 13701777608
Fax
021-69186006
Email
kangtuochem@163.com
Country
China
ProdList
4232
Advantage
55
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
shanghai sinofluoro chemicals co., ltd.
Tel
15800445152
Fax
021-64278603
Email
sales@sinofluoro.com
Country
China
ProdList
297
Advantage
59
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
More
Less

View Lastest Price from 2-Chloro-4,6-dimethoxypyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-4,6-dimethoxypyrimidine 13223-25-1
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-12
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Chloro-4,6-dimethoxypyrimidine 13223-25-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
2-Chloro-4,6-dimethoxypyrimidine 13223-25-1
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100g , 1kg, 5kg , 50kg
Release date
2020-01-07

13223-25-1, 2-Chloro-4,6-dimethoxypyrimidineRelated Search:

Dimethoxymethane 2,6-Dimethoxybenzaldehyde Diphenyldimethoxysilane 1,1-Dimethoxyethane Dimethyldimethoxysilane Difluorochloromethane 2-CHLORO-4-METHOXYPYRIMIDINE 4-CHLORO-2,6-DIMETHOXYPYRIMIDINE,6-CHLORO-2,4-DIMETHOXYPYRIMIDINE,6-CHLORO-2,4-DIMETHOXYPYRIMIDINE, 98+% 4,6-Dimethoxypyrimidine 4(1H)-Pyrimidinone, 2-chloro- (9CI) 2-CHLORO-4,6-DIMETHOXY-5-NITRO-PYRIMIDINE 2-CHLORO-4,6-DIMETHOXY-5-PYRIMIDINAMINE 2-Chloro-4,6-dimethoxypyrimidine 4-Chloro-2,6-dimethoxypyrimidine-5-carbaldehyde 6-Chloro-2,4-dimethoxypyrimidine-5-propenoic acid methyl ester 5-CHLORO-4,6-DIMETHOXYPYRIMIDINE

  • 2-CHLORO-4,6-DIMETHOXYPYRIMIDINE
  • 4-methoxybenzoicacidsodium
  • PYRIMIDINE, 2-CHLORO-4,6-DIMETHOXY-
  • 2-CHLOR-4,6-DIMETHOXYPYRIMIDINE
  • 2-CHLORO-4,6-DIMETHOXYPYRIMIDINE 98+%
  • 4,6-diMethoxypyriMidine-2-chloro
  • 2-Chloro-4,6-dimethoxypyrimidine >=98.0%
  • 2-Chloro-4,6-dimethoxypyrimidine &gt
  • oro-4,6-dimethoxypyrimidine
  • 2-Chloro-4,6-dimethoxypyrimidine ISO 9001：2015 REACH
  • 2-Chloro-4,6-dimethoxypyrimidine/ 13223-25-1
  • -Chloro-4,6-dimethoxypyrimidine
  • 13223-25-1
  • 1851-48-9
  • Pyrimidines
  • Heterocyclic Building Blocks
  • Building Blocks
  • ETHER
  • Heterocycle-Pyrimidine series
  • Pyrimidines
  • Building Blocks
  • Heterocyclic Building Blocks
  • Dimethoxy pyrimidines
  • Pyrimidine