ChemicalBook > CAS DataBase List > 4-Nitrobenzoyl chloride

4-Nitrobenzoyl chloride

Product Name
4-Nitrobenzoyl chloride
CAS No.
122-04-3
Chemical Name
4-Nitrobenzoyl chloride
Synonyms
P-NITROBENZOYL CHLORIDE;PNBC;4-Nitrobenzoyl;SKL748;4-Nitrobenzoyl chlor;p-Nitrobenzoyl chlori;LABOTEST-BB LT00077260;4-nitro-benzoylchlorid;p-nitro-benzoylchlorid;NITROBENZOYL-4 CHLORIDE
CBNumber
CB2182076
Molecular Formula
C7H4ClNO3
Formula Weight
185.56
MOL File
122-04-3.mol
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4-Nitrobenzoyl chloride Property

Melting point:
71-74 °C (lit.)
Boiling point:
202-205 °C/105 mmHg (lit.)
Density 
1.53
refractive index 
1.5890 (estimate)
Flash point:
102 °C
storage temp. 
Store below +30°C.
solubility 
Soluble in terahydrofuran, dichloromethane, chloroform and pyridine.
form 
Flakes or Crystals
color 
Yellow
Odor
pungent odor
Water Solubility 
Decomposes
Sensitive 
Moisture Sensitive
Merck 
14,6589
BRN 
473192
Stability:
Stable, but moisture sensitive. Combustible. Incompatible with water, alcohols, strong oxidizing agents, strong bases.
InChIKey
SKDHHIUENRGTHK-UHFFFAOYSA-N
CAS DataBase Reference
122-04-3(CAS DataBase Reference)
NIST Chemistry Reference
4-Nitrobenzoic acid chloride(122-04-3)
EPA Substance Registry System
p-Nitrobenzoyl chloride (122-04-3)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3261 8/PG 2
WGK Germany 
2
RTECS 
DM6651000
9-19-21
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29163900
Toxicity
LD50 orally in Rabbit: 5600 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.06772
Product name
4-Nitrobenzoyl chloride
Purity
for synthesis
Packaging
5G
Price
$26.2
Updated
2024/03/01
Sigma-Aldrich
Product number
8.06772
Product name
4-Nitrobenzoyl chloride
Purity
for synthesis
Packaging
250g
Price
$111
Updated
2024/03/01
Sigma-Aldrich
Product number
112208
Product name
4-Nitrobenzoyl chloride
Purity
98%
Packaging
50g
Price
$43.7
Updated
2024/03/01
Sigma-Aldrich
Product number
112208
Product name
4-Nitrobenzoyl chloride
Purity
98%
Packaging
250g
Price
$93.8
Updated
2024/03/01
TCI Chemical
Product number
N0176
Product name
4-Nitrobenzoyl Chloride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$22
Updated
2023/06/20
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4-Nitrobenzoyl chloride Chemical Properties,Usage,Production

Chemical Properties

yellow needles or powder

Uses

4-Nitrobenzoyl chloride is used in the preparation of polysubstituted furanonaphthoquinoines. It is also involved in Michael addition, Henry reaction, O-alkylation and cycloaddition reactions. Further, it is employed as an intermediate in active pharmaceutical ingredient and dyes.

Uses

4-Nitrobenzoyl Chloride is used inorganic syntheses such as Michael additions. Also used in the synthesis of polysubstituted furanonaphthoquinoines.

General Description

Yellow needles or powder with a pungent odor.

Air & Water Reactions

Unstable in moist surroundings and should be kept in a tightly-closed container. React with water or steam .

Reactivity Profile

4-Nitrobenzoyl chloride is incompatible with bases (including amines), with strong oxidizing agents, and with alcohols. May react with reducing agents. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Flash point data are not available for 4-Nitrobenzoyl chloride, but 4-Nitrobenzoyl chloride is combustible.

Safety Profile

Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and Cl-. See also NITRO COhlPOUNDS OF AROMATIC HYDROCARBONS and CHLORIDES.

Purification Methods

Crystallise the acid chloride from dry pet ether (b 60-80o), *C6H6 or CCl4. Distil it under vacuum. Irritant. [Adama & Jenkins Org Synth Coll Vol I 394 1941, Beilstein 9 III 1709, 9 IV 1191.]

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4-Nitrobenzoyl chloride Suppliers

ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
6269
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9920
Advantage
58
Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.
Tel
027-65526929 15102793023
Fax
027-65526669
Email
hbhxry@foxmail.com
Country
China
ProdList
2006
Advantage
55
Jinan Carbotang Biotech Co.,Ltd.
Tel
+8615866703830
Email
figo.gao@foxmail.com
Country
China
ProdList
8497
Advantage
58
Yurui (Shanghai) Chemical Co., Ltd.
Tel
+86-021-50456736 +8613761615711
Fax
021-50761379
Email
yuki@riyngroup.com
Country
China
ProdList
1028
Advantage
58
Hubei Zhonglong Kangsheng fine chemical Co.,Ltd
Tel
027-027-82752821 18186694582
Fax
027-82752821
Email
323495346@qq.com
Country
China
ProdList
3583
Advantage
58
Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd
Tel
18072846723; 18072846723
Email
caigou1@witofly.com
Country
China
ProdList
3037
Advantage
58
Hubei Zhonglong Kangsheng Fine Chemical Co., Ltd.
Tel
18171205315
Email
1213219329@qq.com
Country
China
ProdList
5087
Advantage
58
Guangzhou CATO Research Chemicals Inc.
Tel
+86-020-81960175-617 +8615602392859
Email
Intermediate@cato-chem.com
Country
China
ProdList
8046
Advantage
58

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