P-NITROBENZOYL-L-GLUTAMIC ACID
- Product Name
- P-NITROBENZOYL-L-GLUTAMIC ACID
- CAS No.
- 6758-40-3
- Chemical Name
- P-NITROBENZOYL-L-GLUTAMIC ACID
- Synonyms
- TIMTEC-BB SBB007743;N-P-Nitro-Benzoylglutamic Acid;P-NITROBENZOYL-L-GLUTAMIC ACID;N-(4-nitrobenzoyl)glutamic acid;N-P-NITROBENZOYL-L-GLUTAMIC ACID;N-(4-NITRO BENZOYL)-L-GLUTAMIC ACID;L-Glutamic acid, N-(4-nitrobenzoyl)-;Butyl Parahydroxybenzoate Impurity 9;P-NITROBENZOYL-L-GLUTAMIC ACID USP/EP/BP;(S)-2-(4-NitrobenzaMido)pentanedioic acid
- CBNumber
- CB2368818
- Molecular Formula
- C12H12N2O7
- Formula Weight
- 296.23
- MOL File
- 6758-40-3.mol
P-NITROBENZOYL-L-GLUTAMIC ACID Property
- Melting point:
- 117-118 °C(lit.)
- Boiling point:
- 619.9±55.0 °C(Predicted)
- Density
- 1.501±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Ethyl Acetate (Slightly), Methanol (Sparingly)
- form
- Powder
- pka
- 3.20±0.10(Predicted)
- color
- Almost white
- optical activity
- -3.7°(C=0.01g/mL, ETOH, 20°C, 589nm)
Safety
- WGK Germany
- 3
- HS Code
- 29242998
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N493685
- Product name
- N-(4-Nitrobenzoyl)-L-glutamicAcid
- Packaging
- 25g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- AS48009
- Product name
- (S)-2-(4-Nitrobenzamido)pentanedioic acid
- Purity
- 97% ee
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- AS48009
- Product name
- (S)-2-(4-Nitrobenzamido)pentanedioic acid
- Purity
- 97% ee
- Packaging
- 5G
- Price
- $153
- Updated
- 2021/12/16
- Product number
- 094890
- Product name
- (S)-2-(4-Nitrobenzamido)pentanedioic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- AAA0004896
- Product name
- N-PARA-NITROBENZOYL-L-GLUTAMIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $255.15
- Updated
- 2021/12/16
P-NITROBENZOYL-L-GLUTAMIC ACID Chemical Properties,Usage,Production
Chemical Properties
ALMOST WHITE POWDER
Uses
N-(4-Nitrobenzoyl)-L-glutamic Acid is used in the synthesis of (-)-α-Acetylmethadol, which is a synthetic opioid that is used in the treatment of opiate dependence.
Synthesis
122-04-3
142-47-2
6758-40-3
GENERAL STEPS: 18.73 g (0.11 mol) of sodium glutamate and 75 g of water were added to the reaction vessel, adjusted to pH=8 using 1 mol/L aqueous sodium hydroxide solution, and mixed with stirring. Subsequently, 28.31 g of dichloroethane solution of 4-nitrobenzoyl chloride prepared in step (1) was slowly added dropwise to the reaction system at 0 °C. During the dropwise addition, the pH of the reaction system was adjusted with 1 mol/L aqueous sodium hydroxide solution, maintaining pH=8. The color of the reaction solution gradually changed from white to purple, indicating that the reaction proceeded. The reaction was continued for 1 h at room temperature to ensure the completion of the reaction. After completion of the reaction, electrostatic layered separation was carried out and the organic layer was extracted twice with water. The combined aqueous layers were acidified by adjusting to PH=1 with hydrochloric acid, and the precipitated crystals were filtered and dried to afford N-p-nitrobenzoylglutamic acid 29.81 g. The purity of the product was 98.43% by HPLC, and the yield was 99.03% (based on 4-nitrobenzoyl chloride).
References
[1] Patent: CN105439895, 2016, A. Location in patent: Paragraph 0027; 0028
P-NITROBENZOYL-L-GLUTAMIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from P-NITROBENZOYL-L-GLUTAMIC ACID manufacturers
- Product
- Folic acid impurity 20 6758-40-3
- Price
- US $0.00-0.00/mg
- Min. Order
- 5mg
- Purity
- 95%+
- Supply Ability
- 1000mg
- Release date
- 2025-02-10
- Product
- P-NITROBENZOYL-L-GLUTAMIC ACID 6758-40-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-08