4-Aminohippuric acid
- Product Name
- 4-Aminohippuric acid
- CAS No.
- 61-78-9
- Chemical Name
- 4-Aminohippuric acid
- Synonyms
- PAH;P-AMINOHIPPURIC ACID;POLYNUCLEAR AROMATIC HYDROCARBONS;paha;Nefrotest;N-glycine;Aminohippuric;pah(aminoacid);AKOS BBS-00006940;p-amino-hippuricaci
- CBNumber
- CB5348161
- Molecular Formula
- C9H10N2O3
- Formula Weight
- 194.19
- MOL File
- 61-78-9.mol
4-Aminohippuric acid Property
- Melting point:
- 199-200 °C (dec.)(lit.)
- Boiling point:
- 330.62°C (rough estimate)
- Density
- 1.356
- refractive index
- 1.5600 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- DMF: 33 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 20 mg/ml
- form
- Crystalline Powder
- pka
- pKa 3.8 (Uncertain)
- color
- Off-white to grayish
- PH
- 3.0-3.5 (20g/l, H2O, 20℃)
- Water Solubility
- Soluble in alcohol, chloroform, benzene, and acetone. Insoluble in water, ether, carbon, and tetrachloride.
- Merck
- 14,442
- BRN
- 1213676
- InChIKey
- HSMNQINEKMPTIC-UHFFFAOYSA-N
- CAS DataBase Reference
- 61-78-9(CAS DataBase Reference)
- EPA Substance Registry System
- P-Aminohippuric acid (61-78-9)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
- F
- 8-9-23
- TSCA
- Yes
- HS Code
- 29242990
- Hazardous Substances Data
- 61-78-9(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHR3174
- Product name
- Aminohippuric Acid
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 500MG
- Price
- $200
- Updated
- 2024/03/01
- Product number
- 8.14621
- Product name
- 4-Aminohippuric acid
- Purity
- for synthesis
- Packaging
- 25g
- Price
- $191
- Updated
- 2024/03/01
- Product number
- 08090
- Product name
- p-Aminohippuric acid
- Purity
- ≥98.0% (T)
- Packaging
- 50g
- Price
- $387
- Updated
- 2023/01/07
- Product number
- A0313
- Product name
- 4-Aminohippuric Acid
- Purity
- >99.0%(T)
- Packaging
- 10g
- Price
- $171
- Updated
- 2024/03/01
- Product number
- A0313
- Product name
- 4-Aminohippuric Acid
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $342
- Updated
- 2024/03/01
4-Aminohippuric acid Chemical Properties,Usage,Production
Description
4-Aminohippuric acid is a substrate for various renal transporters that has been used in the study of anion uptake in the kidney. It is a substrate for organic anion transporter 1 (OAT1; Km = 14.3 μM in X. laevis oocytes), the human inorganic phosphate transporter (NPT1; Km = 2.66 mM in HEK293 cells), and apical multidrug resistance protein (MDR2; Km = 880 μM in HEK293 cells). 4-Aminohippuric acid is a glycine amide form of 4-aminobenzoic acid . Formulations containing 4-aminohippuric acid have been used as markers to determine renal plasma flow.
Chemical Properties
off-white to greyish crystalline powder
Uses
muscle relaxant (smooth)
Uses
p-Aminohippuric acid has been used as infusions to measure plasma flow.
Uses
4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.
Definition
ChEBI: P-aminohippuric acid is an N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow. It has a role as a Daphnia magna metabolite. It is a conjugate acid of a p-aminohippurate.
General Description
Renal tubules secretes para amino hippuric acid/PAH.
Biochem/physiol Actions
Para-aminohippuric acid(PAH) is used as a marker in nutrition studies to measure the flow of blood in pigs, which inturn helps to determine the portal-drained viscera (PDV) flux of nutrients.
Synthesis
4-Aminohippuric acid is prepared by reacting p-nitrobenzoyl chloride with glycine, followed by reducing the p-nitro group with tin and hydrochloric acid.
Purification Methods
Crystallise the acid from H2O. It is soluble in organic solvents. [Cohen & McGilvery J Biol Chem 169 119 1945, 171 121 1947, Meunzen et al. J Biol Chem 26 469 1926, Beilstein 14 III 1069, 14 IV 1152.]
References
[1] B. ZMBOVA . Synthesis of p-aminohippuric acid analog and its labeling by technetium-99m[J]. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1989, 40 3: Pages 225-234. DOI:10.1016/0883-2889(89)90152-4.
[2] W P DEISS P P C. Studies in para-aminohippuric acid synthesis in the human: its application as a liver function test.[J]. Journal of Clinical Investigation, 1950, 29 8: 1014-1020. DOI:10.1172/JCI102332.
[3] M. SHEAT M. M Zenab F Saeed. Synthesis of Some of Azo, Triazines and Schiff Bases Compounds from 4-Aminohippuric Acid[J]. Journal of Education Science, 2009, 47 1: 1-8. DOI:10.33899/edusj.2009.57930.
[4] T SEKINE. Expression cloning and characterization of a novel multispecific organic anion transporter.[J]. The Journal of Biological Chemistry, 1997, 272 30: 18526-18529. DOI:10.1074/jbc.272.30.18526.
[5] HIROSHI UCHINO . p-Aminohippuric Acid Transport at Renal Apical Membrane Mediated by Human Inorganic Phosphate Transporter NPT1[J]. Biochemical and biophysical research communications, 2000, 270 1: Pages 254-259. DOI:10.1006/bbrc.2000.2407.
4-Aminohippuric acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Aminohippuric acid manufacturers
- Product
- 4-Aminohippuric acid 61-78-9
- Price
- US $8.00-2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-25
- Product
- 4-AMINOHIPPURIC ACID 61-78-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-09-05
- Product
- 4-AMINOHIPPURIC ACID 61-78-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-14