DIHYDROFOLIC ACID
- Product Name
- DIHYDROFOLIC ACID
- CAS No.
- 4033-27-6
- Chemical Name
- DIHYDROFOLIC ACID
- Synonyms
- dihydrofolate;FAH2;DIHYDROFOLIC ACID;FolinicAcidEPImpurityGHCl;Folinic Acid EP Impurity G;Levofolinate EP Impurity G;7,8-Dihydrofolic acid (DHF);DIHYDROPTEROYL-L-GLUTAMIC ACID;Folic Acid 7,8-Dihydro Impurity;Calcium levoflonate EP impurity G
- CBNumber
- CB4432012
- Molecular Formula
- C19H21N7O6
- Formula Weight
- 443.41
- MOL File
- 4033-27-6.mol
DIHYDROFOLIC ACID Property
- Melting point:
- >160°C (dec.)
- Density
- 1.69±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- 0.1 M NaOH: 10 mg/mL, slightly hazy, orange
- pka
- pKa 1.38(H2O t=25 I=0.10) (Occasionally);3.84(H2O t=25 I=0.10) (Occasionally)
- form
- Solid
- color
- Light Beige to Beige
- BRN
- 69017
- Stability:
- Air Sensitive, Hygroscopic, Temperature Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D7006
- Product name
- Dihydrofolic acid
- Purity
- ≥90%
- Packaging
- 10mg
- Price
- $123
- Updated
- 2024/03/01
- Product number
- D7006
- Product name
- Dihydrofolic acid
- Purity
- ≥90%
- Packaging
- 25mg
- Price
- $276
- Updated
- 2024/03/01
- Product number
- D7006
- Product name
- Dihydrofolic acid
- Purity
- ≥90%
- Packaging
- 100mg
- Price
- $915
- Updated
- 2024/03/01
- Product number
- D449700
- Product name
- Dihydrofolic acid
- Packaging
- 25mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FD170209
- Product name
- Dihydro Folic Acid
- Packaging
- 10mg
- Price
- $200
- Updated
- 2021/12/16
DIHYDROFOLIC ACID Chemical Properties,Usage,Production
Uses
antidote to methotrexate toxicity
Uses
Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).
Uses
Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).
Definition
ChEBI: Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a dihydrofolate(2-).
General Description
Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase.
Biochem/physiol Actions
Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).
Purification Methods
DHFA is best purified by suspending (1g mostly dissolved)) in ice-cold sodium ascorbate (300mL of 10% at pH 6.0, prepared by adjusting the pH of 30g of sodium ascorbate in 150mL of H2O by adding 1N NaOH dropwise using a gla
DIHYDROFOLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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