DIHYDROFOLIC ACID

ChemicalBook > CAS DataBase List > DIHYDROFOLIC ACID

Product Name: DIHYDROFOLIC ACID
CAS No.: 4033-27-6
Chemical Name: DIHYDROFOLIC ACID
Synonyms: dihydrofolate;FAH2;DIHYDROFOLIC ACID;FolinicAcidEPImpurityGHCl;Folinic Acid EP Impurity G;Levofolinate EP Impurity G;7,8-Dihydrofolic acid (DHF);DIHYDROPTEROYL-L-GLUTAMIC ACID;Folic Acid 7,8-Dihydro Impurity;Calcium levoflonate EP impurity G
CBNumber: CB4432012
Molecular Formula: C19H21N7O6
Formula Weight: 443.41
MOL File: 4033-27-6.mol

Less

DIHYDROFOLIC ACID Property

Melting point:: >160°C (dec.)
Density: 1.69±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: 0.1 M NaOH: 10 mg/mL, slightly hazy, orange
pka: pKa 1.38(H2O t=25 I=0.10) (Occasionally);3.84(H2O t=25 I=0.10) (Occasionally)
form: Solid
color: Light Beige to Beige
biological source: synthetic (organic)
BRN: 69017
Stability:: Air Sensitive, Hygroscopic, Temperature Sensitive

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D7006
Product name: Dihydrofolic acid
Purity: ≥90%
Packaging: 10mg
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: D7006
Product name: Dihydrofolic acid
Purity: ≥90%
Packaging: 25mg
Price: $276
Updated: 2024/03/01

Sigma-Aldrich

Product number: D7006
Product name: Dihydrofolic acid
Purity: ≥90%
Packaging: 100mg
Price: $915
Updated: 2024/03/01

TRC

Product number: D449700
Product name: Dihydrofolic acid
Packaging: 25mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD170209
Product name: Dihydro Folic Acid
Packaging: 10mg
Price: $200
Updated: 2021/12/16

Less

DIHYDROFOLIC ACID Chemical Properties,Usage,Production

Uses

antidote to methotrexate toxicity

Uses

Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).

Definition

ChEBI: Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a dihydrofolate(2-).

General Description

Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase.

Biochem/physiol Actions

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Purification Methods

DHFA is best purified by suspending (1g mostly dissolved)) in ice-cold sodium ascorbate (300mL of 10% at pH 6.0, prepared by adjusting the pH of 30g of sodium ascorbate in 150mL of H2O by adding 1N NaOH dropwise using a gla

DIHYDROFOLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

Less

DIHYDROFOLIC ACID Suppliers

Canada 1 China 81 Germany 3 India 4 Switzerland 1 United Kingdom 3 United States 10 Global 103

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5047
Advantage: 50

Beijing Comparison Pharmaceutical Technology Co., Ltd

Tel: 010-010-52878169 15801002657
Email: sales@bjcomparison.com
Country: China
ProdList: 4717
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

TianJin Alta Scientific Co., Ltd.

Tel: 022-65378550-8551
Fax: +86-022-2532-9655
Email: contact@altascientific.com
Country: China
ProdList: 2773
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18070
Advantage: 56

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb6@aikonchem.com
Country: China
ProdList: 16684
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20806
Advantage: 60

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Hubei Yangxin Medical Technology Co., Ltd.

Tel: 15374522761
Fax: QQ:2853117752
Email: 3003392093@qq.com
Country: China
ProdList: 8706
Advantage: 55

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-85370565-229 18080489829
Email: 3004654993@qq.com
Country: China
ProdList: 8909
Advantage: 60

JinJin Le Chemical Co., Ltd

Tel: 10106090
Email: jjlchem2@163.com
Country: China
ProdList: 9981
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 021-021-52271985 17721149837
Fax: +86 (21) 52271987
Email: sales@9dingchem.com
Country: China
ProdList: 19800
Advantage: 60

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7819
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19908
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9911
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15352
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30236
Advantage: 58

Guangzhou Dreampharm Biotechnology Co., Ltd.

Tel: 020-36607679 17825480238
Fax: QQ 3008233717
Email: 3008233746@qq.com
Country: China
ProdList: 9919
Advantage: 12

Shenzhen ruikai de biotechnology co., ltd.

Tel: 0755-61348847 17820674378
Fax: 0755-21016893
Email: 2682116078@qq.com
Country: China
ProdList: 7843
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-81139210 +86-18192627656
Fax: +86-29-88380327
Email: 1059@dideu.com
Country: China
ProdList: 3003
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988968278
Fax: QQ：3283937693
Email: sales@ubiochem.com
Country: China
ProdList: 4297
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD

Tel: 0755-0755-0755-83725350 13380397412
Fax: 0755-28094224
Email: 3001280422@qq.com
Country: China
ProdList: 10005
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 11438
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 31121
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., LTD

Tel: 0519-88910898 18661161657
Email: yaoxiangqiu2021@163.com
Country: China
ProdList: 9996
Advantage: 58

JinOu Biomedical (Nanjing) Co., Ltd.

Tel: 13000000000
Fax: jinoupharma@163
Email: jinoupharma@163.com
Country: China
ProdList: 11721
Advantage: 58

Molcoo Chemicals Inc.

Tel: 18576690171 17386083646
Email: 3001006472@qq.com
Country: China
ProdList: 11837
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62075
Advantage: 58

Chengdu Push Bio-Technology Co., Ltd.

Tel: 18080489829
Email: 3004654993@qq.com
Country: China
ProdList: 9209
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Scinova Biotech(Guangzhou) Co., Ltd.

Tel: 13268215580
Email: scinova_sales@163.com
Country: China
ProdList: 7025
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175-877 18933936954
Email: tianwen.zhan@cato-chem.com
Country: China
ProdList: 7734
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 17730
Advantage: 58

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2619
Advantage: 58

Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7978
Advantage: 58

Shenzhen Excellent Biomedical Technology Co., Ltd.

Tel: 18318671572
Email: 2850803126@qq.com
Country: China
ProdList: 4925
Advantage: 58

Less

View Lastest Price from DIHYDROFOLIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: DIHYDROFOLIC ACID 4033-27-6
Price: US $1.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KG
Release date: 2024-07-26

Shaanxi Dideu Medichem Co. Ltd

Product: DIHYDROFOLIC ACID 4033-27-6
Price: US $0.10-0.10/KG
Min. Order: 10KG
Purity: 99%+
Supply Ability: 10000KG
Release date: 2024-04-24

4033-27-6, DIHYDROFOLIC ACIDRelated Search:

Glycine Vitamin B12 Folic acid 2-[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]aminopentanedioic acid Calcium levofolinate Calcium N5-methyltetrahydrofolate 5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid 10-Formylfolic Acid Folinic Acid IMpurity E 2-Amino-7-(chloromethyl)pteridin-4(1H)-one 2,4,5-Triamino-6-hydroxypyrimidine sulfate (S)-N-[4-[[(2-AMino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-glutaMic Acid 6-hydroxymethylpterin Folic Acid Impurity C 5-Methyl Tetrahedropteroic Acid (Mixture of DiastereoMers) folcysteine (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6- yl]methylamino]benzoyl]amino]pentanedioic acid 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE

Folinic Acid EP Impurity G

Folinic Acid EP Impurity G (7,8-Dihydrofolic Acid)

(S)-2-(4-(((2-aMino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid

7,8-Dihydrofolic acid (DHF)

Dihydrofolic acid 7,8-Dihydropteroyl-L-glutaMic acid

N-[4-[[(2-aMino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-GlutaMic acid

Folinic Acid Impurity G (7,8-Dihydrofolic Acid)

7,8-DIHYDROPTEROYL-L-GLUTAMIC ACID

FAH2

DIHYDROPTEROYL-L-GLUTAMIC ACID

DIHYDROFOLIC ACID

dihydrofolate

2-[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid

7,8-Dihydropteroyl-L-glutamic acid, Dihydropteroyl-L-glutamic acid, FAH2

N-[4-[[[(2-Amino-1,4,5,6-tetrahydro-4-oxopteridin)-6-yl]methyl]amino]benzoyl]-L-glutamic acid

Folic acid impurity 2/Folinic Acid EP Impurity G/Dihydrofolic acid/7,8-Dihydrofolic Acid

Impurity G of Calcium Levofolinate

Folic Acid 7,8-Dihydro Impurity

Levofolinate EP Impurity G

L-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-

2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid

(4-(((2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid

Calcium levoflonate EP impurity G

FolinicAcidEPImpurityGHCl

(S)-2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid

4033-27-6

40033-27-6

C19H21N7O6

Cell Signaling Enzymes

Application Index

Biochemicals and Reagents

BioChemical

Cofactors

Dihydrofolate reductase

Enzymes, Inhibitors, and Substrates

Oxidation-Reduction

Substrate/Cofactor