DIHYDROFOLIC ACID

ChemicalBook > CAS DataBase List > DIHYDROFOLIC ACID

Product Name: DIHYDROFOLIC ACID
CAS No.: 4033-27-6
Chemical Name: DIHYDROFOLIC ACID
Synonyms: dihydrofolate;FAH2;DIHYDROFOLIC ACID;FolinicAcidEPImpurityGHCl;Folinic Acid EP Impurity G;Levofolinate EP Impurity G;7,8-Dihydrofolic acid (DHF);DIHYDROPTEROYL-L-GLUTAMIC ACID;Folic Acid 7,8-Dihydro Impurity;Calcium levoflonate EP impurity G
CBNumber: CB4432012
Molecular Formula: C19H21N7O6
Formula Weight: 443.41
MOL File: 4033-27-6.mol

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DIHYDROFOLIC ACID Property

Melting point:: >160°C (dec.)
Density: 1.69±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: 0.1 M NaOH: 10 mg/mL, slightly hazy, orange
pka: pKa 1.38(H2O t=25 I=0.10) (Occasionally);3.84(H2O t=25 I=0.10) (Occasionally)
form: Solid
color: Light Beige to Beige
BRN: 69017
Stability:: Air Sensitive, Hygroscopic, Temperature Sensitive

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D7006
Product name: Dihydrofolic acid
Purity: ≥90%
Packaging: 10mg
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: D7006
Product name: Dihydrofolic acid
Purity: ≥90%
Packaging: 25mg
Price: $276
Updated: 2024/03/01

Sigma-Aldrich

Product number: D7006
Product name: Dihydrofolic acid
Purity: ≥90%
Packaging: 100mg
Price: $915
Updated: 2024/03/01

TRC

Product number: D449700
Product name: Dihydrofolic acid
Packaging: 25mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD170209
Product name: Dihydro Folic Acid
Packaging: 10mg
Price: $200
Updated: 2021/12/16

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DIHYDROFOLIC ACID Chemical Properties,Usage,Production

Uses

antidote to methotrexate toxicity

Uses

Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).

Uses

Definition

ChEBI: Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a dihydrofolate(2-).

General Description

Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase.

Biochem/physiol Actions

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Purification Methods

DHFA is best purified by suspending (1g mostly dissolved)) in ice-cold sodium ascorbate (300mL of 10% at pH 6.0, prepared by adjusting the pH of 30g of sodium ascorbate in 150mL of H2O by adding 1N NaOH dropwise using a gla

DIHYDROFOLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DIHYDROFOLIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: DIHYDROFOLIC ACID 4033-27-6
Price: US $0.10-0.10/KG
Min. Order: 10KG
Purity: 99%+
Supply Ability: 10000KG
Release date: 2024-04-24

4033-27-6, DIHYDROFOLIC ACIDRelated Search:

Glycine Vitamin B12 Folic acid 2-[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]aminopentanedioic acid Calcium levofolinate Calcium N5-methyltetrahydrofolate 5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid 10-Formylfolic Acid Folinic Acid IMpurity E 2-Amino-7-(chloromethyl)pteridin-4(1H)-one 2,4,5-Triamino-6-hydroxypyrimidine sulfate (S)-N-[4-[[(2-AMino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-glutaMic Acid 6-hydroxymethylpterin Folic Acid Impurity C 5-Methyl Tetrahedropteroic Acid (Mixture of DiastereoMers) folcysteine (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6- yl]methylamino]benzoyl]amino]pentanedioic acid 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE

Folinic Acid EP Impurity G

Folinic Acid EP Impurity G (7,8-Dihydrofolic Acid)

(S)-2-(4-(((2-aMino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid

7,8-Dihydrofolic acid (DHF)

Dihydrofolic acid 7,8-Dihydropteroyl-L-glutaMic acid

N-[4-[[(2-aMino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-GlutaMic acid

Folinic Acid Impurity G (7,8-Dihydrofolic Acid)

7,8-DIHYDROPTEROYL-L-GLUTAMIC ACID

FAH2

DIHYDROPTEROYL-L-GLUTAMIC ACID

DIHYDROFOLIC ACID

dihydrofolate

2-[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid

7,8-Dihydropteroyl-L-glutamic acid, Dihydropteroyl-L-glutamic acid, FAH2

N-[4-[[[(2-Amino-1,4,5,6-tetrahydro-4-oxopteridin)-6-yl]methyl]amino]benzoyl]-L-glutamic acid

Folic acid impurity 2/Folinic Acid EP Impurity G/Dihydrofolic acid/7,8-Dihydrofolic Acid

Impurity G of Calcium Levofolinate

Folic Acid 7,8-Dihydro Impurity

Levofolinate EP Impurity G

L-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-

2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid

(4-(((2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid

Calcium levoflonate EP impurity G

FolinicAcidEPImpurityGHCl

4033-27-6

40033-27-6

C19H21N7O6

Cell Signaling Enzymes

Application Index

Biochemicals and Reagents

BioChemical

Cofactors

Dihydrofolate reductase

Enzymes, Inhibitors, and Substrates

Oxidation-Reduction

Substrate/Cofactor