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METHOTREXATE HYDRATE

Product Name
METHOTREXATE HYDRATE
CAS No.
133073-73-1
Chemical Name
METHOTREXATE HYDRATE
Synonyms
L-MTX;MTX HYDRATE;(+)Amethopterin;Antifolan hydrate;METHOTREXATE, VETEC;METHOTREXATE HYDRATE;Methotrexate xhydrate;L-AMETHOPTERIN HYDRATE;Methotrexate trihydrate;(+)-AMETHOPTERIN HYDRATE
CBNumber
CB2704227
Molecular Formula
C20H24N8O6
Formula Weight
472.46
MOL File
133073-73-1.mol
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METHOTREXATE HYDRATE Property

Melting point:
195 °C
storage temp. 
-20°C
solubility 
H2O: insoluble
form 
powder
color 
yellow
optical activity
[α]/D +21.0±2.0°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey
FBOZXECLQNJBKD-ZDUSSCGKSA-N
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Safety

Hazard Codes 
T
Risk Statements 
61-25-36/38-46
Safety Statements 
53-26-36/37-45-36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
MA1225000
HS Code 
29339980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
06563
Product name
Methotrexate hydrate
Purity
≥99.0% (sum of enantiomers, HPLC)
Packaging
5mg
Price
$27.9
Updated
2024/03/01
Sigma-Aldrich
Product number
06563
Product name
Methotrexate hydrate
Purity
≥99.0% (sum of enantiomers, HPLC)
Packaging
25mg
Price
$77.6
Updated
2024/03/01
TCI Chemical
Product number
M1664
Product name
Methotrexate Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$171
Updated
2024/03/01
TCI Chemical
Product number
M1664
Product name
Methotrexate Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$624
Updated
2024/03/01
Cayman Chemical
Product number
13960
Product name
Methotrexate (hydrate)
Packaging
100mg
Price
$45
Updated
2024/03/01
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METHOTREXATE HYDRATE Chemical Properties,Usage,Production

Description

Methotrexate (MTX) is similar in structure to folic acid and aminopterin . It acts by inhibiting the metabolism of folic acid and blocking key enzymes in the synthesis of purines and pyrimidines required for cell proliferation. MTX is known to induce adenosine release, which mediates many of its anti-inflammatory effects, including the reduction of proinflammatory cytokines. Formulations containing MTX have been used as immunosuppressants, in the treatment of cancer, autoimmune disease, ectopic pregnancy, and for the induction of medical abortions. MTX formulations have been considered the gold standard of disease-modifying antirheumatic drug (DMARD) therapy to treat both the immune-inflammatory and joint destructive processes of rheumatoid arthritis.

Chemical Properties

yellow to orange crystalline powder

Uses

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

Uses

Methotrexate hydrate has been used:

  • as a dihydrofolate (DHFR)?inhibitor in sphere forming assay culture
  • as a component of dulbecco′ modified Eagle′s medium (DMEM) for selection of transfected cells
  • in viability and co-culture assays

Definition

ChEBI: Methotrexate hydrate is a member of folic acids.

Biochem/physiol Actions

Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.

References

Wessels et al. (2008), Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis; Rheumatology (Oxford), 47 249 Allegra et al. (1987), Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate; Biol. Chem., 262 13520 Chu et al. (1990), Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells; Biol. Chem., 265 8470 Gerards et al. (2003), Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis; Rheumatology (Oxford), 42 1189 Friedman and Cronstein (2019), Methotrexate mechanism in treatment of rheumatoid arthritis; Joint Bone Spine, 86 301 Smolen and Steiner (2003), Therapeutic strategies for rheumatoid arthritis; Rev. Drug Discov., 2 473

METHOTREXATE HYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHOTREXATE HYDRATE Suppliers

Americas 1 Belgium 1 China 82 Europe 1 Germany 1 India 9 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 4 United States 13 Global 115
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
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View Lastest Price from METHOTREXATE HYDRATE manufacturers

Dideu Industries Group Limited
Product
METHOTREXATE HYDRATE 133073-73-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01
Shaanxi Dideu Medichem Co. Ltd
Product
L(+)-AMethopterin hydrate 133073-73-1
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30
Career Henan Chemical Co
Product
METHOTREXATE HYDRATE 133073-73-1
Price
US $10.00/KG/Tin
Min. Order
1KG
Purity
99%
Supply Ability
100
Release date
2019-06-27

133073-73-1, METHOTREXATE HYDRATERelated Search:

METHOTREXATE HYDRATE CELL/INSECT CELL*CU LTURE TESTE SU 4312 Folic acid (+/-)AMETHOPTERIN Methotrexate sodium METHOTREXATE HYDRATE 7-CYANOMETHOTREXATE DIMETHYL ESTER METHOTREXATE DIMETHYL ESTER Dichloromethotrexate 7-HYDROXY METHOTREXATE METHOTREXATE-METHYL-D3, DIMETHYL ESTER METHOTREXATE-D3 METHOTREXATE SODIUM SALT, [3',5',7'-3H] 7-HYDROXY METHOXTREXATE-D3 FLUORESCEIN METHOTREXATE, TRIAMMONIUM SALT METHOTREXATE-[3',5',7-3H(N)] DISODIUM SALT [3',5',7-3H]METHOTREXATE, SODIUM SALT METHOTREXATE DISODIUM SALT, [L-GLUTAMIC (1-14C)]

  • L-Glutamic acid,N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, hydrate (9CI)
  • (+)AMETHOPTERINE HYDRATE
  • (+)-AMETHOPTERIN HYDRATE
  • 4-AMINO-10-METHYLFOLIC ACID HYDRATE
  • METHYLAMINOPTERIN HYDRATE
  • METHOTREXATE HYDRATE
  • L-4-AMINO-N10-METHYLPTEROYL-GLUTAMIC ACID HYDRATE
  • L-(+)-AMETHOPTERIN HYDRATE
  • L-AMETHOPTERIN HYDRATE
  • MTX HYDRATE
  • L-MTX
  • L(+)-Amethopterin hydrate,99%
  • Antifolan hydrate
  • l-4-amino-n10-methylpteroylglutamic acid
  • 4-Amino-10-methylfolic acid hydrate, Antifolan hydrate, Methotrexate hydrate, Methylaminopterin hydrate, MTX hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate
  • 4-Amino-10-methylfolic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, Methylaminopterin hydrate, MTX hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate
  • Methotrexate hydrate,4-Amino-10-methylfolic acid hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, MTX hydrate, Methylaminopterin hydrate
  • Methotrexate hydrate,4-Amino-10-methylfolic acid hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, MTX hydrate, Methotrexate hydrate, Methylaminopte
  • L(+)-AMethopterin hydrate, 99% 100MG
  • Methotrexate hydrate 4-AMino-10-Methylfolic acid hydrate
  • N-[4-[[(2,4-diaMino-6-pteridinyl)Methyl]MethylaMino]ben
  • Methotrexate hydrate Vetec(TM) reagent grade, 98%
  • Methotrexate hydrate, >=98%
  • Methotrexate trihydrate
  • METHOTREXATE, VETEC
  • Methotrexate hydrate(1:x)
  • Methotrexate xhydrate
  • METHOTREXATE HYDRATE USP/EP/BP
  • Methotrexate hydrate, ≥98% (HPLC), powder
  • Methotrexate Hydrate (MTR), 98%
  • (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
  • (+)Amethopterin
  • (4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid hydrate(1:x)
  • Methotrexate Hydrate, ≥ 98.0%
  • 133073-73-1
  • C20H22N8O5H2O
  • Complex Molecules
  • Chiral Building Blocks
  • Asymmetric Synthesis