METHOTREXATE HYDRATE

ChemicalBook > CAS DataBase List > METHOTREXATE HYDRATE

Product Name: METHOTREXATE HYDRATE
CAS No.: 133073-73-1
Chemical Name: METHOTREXATE HYDRATE
Synonyms: L-MTX;MTX HYDRATE;(+)Amethopterin;Antifolan hydrate;METHOTREXATE, VETEC;METHOTREXATE HYDRATE;Methotrexate xhydrate;L-AMETHOPTERIN HYDRATE;Methotrexate trihydrate;(+)-AMETHOPTERIN HYDRATE
CBNumber: CB2704227
Molecular Formula: C20H24N8O6
Formula Weight: 472.46
MOL File: 133073-73-1.mol

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METHOTREXATE HYDRATE Property

Melting point:: 195 °C
storage temp.: -20°C
solubility: H₂O: insoluble
form: powder
color: yellow
optical activity: [α]/D +21.0±2.0°
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey: FBOZXECLQNJBKD-ZDUSSCGKSA-N

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Safety

Hazard Codes: T
Risk Statements: 61-25-36/38-46
Safety Statements: 53-26-36/37-45-36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: MA1225000
HS Code: 29339980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 06563
Product name: Methotrexate hydrate
Purity: ≥99.0% (sum of enantiomers, HPLC)
Packaging: 5mg
Price: $27.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 06563
Product name: Methotrexate hydrate
Purity: ≥99.0% (sum of enantiomers, HPLC)
Packaging: 25mg
Price: $77.6
Updated: 2024/03/01

TCI Chemical

Product number: M1664
Product name: Methotrexate Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $171
Updated: 2024/03/01

TCI Chemical

Product number: M1664
Product name: Methotrexate Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $624
Updated: 2024/03/01

Cayman Chemical

Product number: 13960
Product name: Methotrexate (hydrate)
Packaging: 100mg
Price: $45
Updated: 2024/03/01

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METHOTREXATE HYDRATE Chemical Properties,Usage,Production

Description

Methotrexate (MTX) is similar in structure to folic acid and aminopterin . It acts by inhibiting the metabolism of folic acid and blocking key enzymes in the synthesis of purines and pyrimidines required for cell proliferation. MTX is known to induce adenosine release, which mediates many of its anti-inflammatory effects, including the reduction of proinflammatory cytokines. Formulations containing MTX have been used as immunosuppressants, in the treatment of cancer, autoimmune disease, ectopic pregnancy, and for the induction of medical abortions. MTX formulations have been considered the gold standard of disease-modifying antirheumatic drug (DMARD) therapy to treat both the immune-inflammatory and joint destructive processes of rheumatoid arthritis.

Chemical Properties

yellow to orange crystalline powder

Uses

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

Uses

Methotrexate hydrate has been used:

as a dihydrofolate (DHFR)?inhibitor in sphere forming assay culture
as a component of dulbecco′ modified Eagle′s medium (DMEM) for selection of transfected cells
in viability and co-culture assays

Definition

ChEBI: Methotrexate hydrate is a member of folic acids.

Biochem/physiol Actions

Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.

References

Wessels et al. (2008), Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis; Rheumatology (Oxford), 47 249 Allegra et al. (1987), Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate; Biol. Chem., 262 13520 Chu et al. (1990), Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells; Biol. Chem., 265 8470 Gerards et al. (2003), Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis; Rheumatology (Oxford), 42 1189 Friedman and Cronstein (2019), Methotrexate mechanism in treatment of rheumatoid arthritis; Joint Bone Spine, 86 301 Smolen and Steiner (2003), Therapeutic strategies for rheumatoid arthritis; Rev. Drug Discov., 2 473

METHOTREXATE HYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHOTREXATE HYDRATE manufacturers

Dideu Industries Group Limited

Product: METHOTREXATE HYDRATE 133073-73-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-01

Shaanxi Dideu Medichem Co. Ltd

Product: L(+)-AMethopterin hydrate 133073-73-1
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 ton
Release date: 2020-04-30

Career Henan Chemical Co

Product: METHOTREXATE HYDRATE 133073-73-1
Price: US $10.00/KG/Tin
Min. Order: 1KG
Purity: 99%
Supply Ability: 100
Release date: 2019-06-27

133073-73-1, METHOTREXATE HYDRATERelated Search:

METHOTREXATE HYDRATE CELL/INSECT CELL*CU LTURE TESTE SU 4312 Folic acid (+/-)AMETHOPTERIN Methotrexate sodium METHOTREXATE HYDRATE 7-CYANOMETHOTREXATE DIMETHYL ESTER METHOTREXATE DIMETHYL ESTER Dichloromethotrexate 7-HYDROXY METHOTREXATE METHOTREXATE-METHYL-D3, DIMETHYL ESTER METHOTREXATE-D3 METHOTREXATE SODIUM SALT, [3',5',7'-3H] 7-HYDROXY METHOXTREXATE-D3 FLUORESCEIN METHOTREXATE, TRIAMMONIUM SALT METHOTREXATE-[3',5',7-3H(N)] DISODIUM SALT [3',5',7-3H]METHOTREXATE, SODIUM SALT METHOTREXATE DISODIUM SALT, [L-GLUTAMIC (1-14C)]

L-Glutamic acid,N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, hydrate (9CI)

(+)AMETHOPTERINE HYDRATE

(+)-AMETHOPTERIN HYDRATE

4-AMINO-10-METHYLFOLIC ACID HYDRATE

METHYLAMINOPTERIN HYDRATE

METHOTREXATE HYDRATE

L-4-AMINO-N10-METHYLPTEROYL-GLUTAMIC ACID HYDRATE

L-(+)-AMETHOPTERIN HYDRATE

L-AMETHOPTERIN HYDRATE

MTX HYDRATE

L-MTX

L(+)-Amethopterin hydrate,99%

Antifolan hydrate

l-4-amino-n10-methylpteroylglutamic acid

4-Amino-10-methylfolic acid hydrate, Antifolan hydrate, Methotrexate hydrate, Methylaminopterin hydrate, MTX hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate

4-Amino-10-methylfolic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, Methylaminopterin hydrate, MTX hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate

Methotrexate hydrate,4-Amino-10-methylfolic acid hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, MTX hydrate, Methylaminopterin hydrate

Methotrexate hydrate,4-Amino-10-methylfolic acid hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, MTX hydrate, Methotrexate hydrate, Methylaminopte

L(+)-AMethopterin hydrate, 99% 100MG

Methotrexate hydrate 4-AMino-10-Methylfolic acid hydrate

N-[4-[[(2,4-diaMino-6-pteridinyl)Methyl]MethylaMino]ben

Methotrexate hydrate Vetec(TM) reagent grade, 98%

Methotrexate hydrate, >=98%

Methotrexate trihydrate

METHOTREXATE, VETEC

Methotrexate hydrate(1:x)

Methotrexate xhydrate

METHOTREXATE HYDRATE USP/EP/BP

Methotrexate hydrate, ≥98% (HPLC), powder

Methotrexate Hydrate (MTR), 98%

(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid

(+)Amethopterin

(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid hydrate(1:x)

Methotrexate Hydrate, ≥ 98.0%

133073-73-1

C20H22N8O5H2O

Complex Molecules

Chiral Building Blocks

Asymmetric Synthesis