Ethyl trifluoropyruvate
- Product Name
- Ethyl trifluoropyruvate
- CAS No.
- 13081-18-0
- Chemical Name
- Ethyl trifluoropyruvate
- Synonyms
- ETHYL 3,3,3-TRIFLUORO-2-OXOPROPANOATE;ETHYL 3,3,3-TRIFLUOROPYRUVATE;E-TFPA;RARECHEM AL BI 1300;ETHYL TRIFLUOROPYRUVATE;Ethyltrifluoropyruvate98%;ETHYL 3,3,3-TRIFLUORO-2-O;Threefluorideethylpyruvate;Ethyl trifluoropyruvate 98%;Ethyl-trifluoroMethylpyruvate
- CBNumber
- CB8333735
- Molecular Formula
- C5H5F3O3
- Formula Weight
- 170.09
- MOL File
- 13081-18-0.mol
Ethyl trifluoropyruvate Property
- Boiling point:
- 42 °C(lit.)
- Density
- 1.283 g/mL at 25 °C (lit.)
- vapor pressure
- 12.49hPa at 25℃
- refractive index
- n20/D 1.341(lit.)
- Flash point:
- 88 °F
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Miscible with dichloromethane.
- form
- Liquid
- color
- Clear colorless to pale yellow
- BRN
- 2087388
- Stability:
- Moisture Sensitive
- InChIKey
- KJHQVUNUOIEYSV-UHFFFAOYSA-N
- LogP
- -0.05
- CAS DataBase Reference
- 13081-18-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,C,Xi
- Risk Statements
- 10-22-36/37/38
- Safety Statements
- 26-37/39-16
- RIDADR
- UN 3272 3/PG 3
- WGK Germany
- 3
- Hazard Note
- Corrosive
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29183000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 510254
- Product name
- Ethyl 3,3,3-trifluoropyruvate
- Purity
- 97%
- Packaging
- 5g
- Price
- $26
- Updated
- 2024/03/01
- Product number
- T1434
- Product name
- Ethyl Trifluoropyruvate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $47
- Updated
- 2024/03/01
- Product number
- T1434
- Product name
- Ethyl Trifluoropyruvate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $135
- Updated
- 2024/03/01
- Product number
- B20611
- Product name
- Ethyl trifluoropyruvate, 97%
- Packaging
- 5g
- Price
- $46.65
- Updated
- 2024/03/01
- Product number
- B20611
- Product name
- Ethyl trifluoropyruvate, 97%
- Packaging
- 25g
- Price
- $184
- Updated
- 2024/03/01
Ethyl trifluoropyruvate Chemical Properties,Usage,Production
Chemical Properties
Clear pale yellow liquid
Uses
Ethyl trifluoropyruvate acts as a building block in synthetic chemistry for the synthesis of fluorine containing compounds. It is also used as a reagent for the preparation of potential biologically active compounds like highly enantioselective organocatalytic hydroxyalkylation of indoles.
Uses
Ethyl 3,3,3-trifluoropyruvate may be used in the preparation of N-heteroaryl(trifluoromethyl)hydroxyalkanoic acid esters.
Uses
Ethyl Trifluoropyruvate is used as a reagent in the preparation of potential biologically active compounds such as in the highly enantioselective organocatalytic hydroxyalkylation of indoles .
General Description
Ethyl 3,3,3-trifluoropyruvate is a trifluoromethylated compound. Enantioselective Friedel–Crafts alkylation of simple phenols and indoles with ethyl 3,3,3-trifluoropyruvate under different reaction conditions have been reported.
Synthesis
To 58 mL (1.0 mL/mmol) of acetonitrile, 10 g (58 mmol, 1.0 eq) of ethyl 3,3,3-trifluorolactate was added and dissolved therein.Furthermore, 11 g (67 mmol, 1.2 eq) of NaClO.5H2O was added, followed by stirring at 20° C. for 30 minutes.As the reaction-terminated liquid was analyzed by 19F-NMR, conversion was 100%, and selectivity was 98%.To the reaction-terminated liquid, 0.38 g (1.5 mmol, 0.026 eq) of sodium thiosulfate pentahydrate was added, followed by stirring, thereby quenching the remaining oxidation agent.Furthermore, 0.33 g (3.9 mmol, 0.067 eq) of sodium hydrogencarbonate and 10 g (70 mmol, 1.2 eq) of sodium sulfate were added, followed by stirring and then removing solid matter by filtration.As the filtrate was quantified with internal standard method (internal standard substance: α,α,α-trifluorotoluene) by 19F-NMR, Ethyl trifluoropyruvate was contained by 56 mmol (quantitative yield: 97%).By a simple distillation (up to 48° C./0.5 kPa) of the filtrate, 7.6 g of Ethyl trifluoropyruvate was obtained. 19F-NMR purity was 99% (40 mmol), and the total yield was 69%.
Ethyl trifluoropyruvate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl trifluoropyruvate manufacturers
- Product
- Ethyl trifluoropyruvate 13081-18-0
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2023-05-19
- Product
- Ethyl trifluoropyruvate 13081-18-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-16
- Product
- Ethyl trifluoropyruvate 13081-18-0
- Price
- US $50.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KG
- Release date
- 2020-10-29