Ethyl trifluoropyruvate

ChemicalBook > CAS DataBase List > Ethyl trifluoropyruvate

Ethyl trifluoropyruvate

Product Name: Ethyl trifluoropyruvate
CAS No.: 13081-18-0
Chemical Name: Ethyl trifluoropyruvate
Synonyms: ETHYL 3,3,3-TRIFLUORO-2-OXOPROPANOATE;ETHYL 3,3,3-TRIFLUOROPYRUVATE;E-TFPA;RARECHEM AL BI 1300;ETHYL TRIFLUOROPYRUVATE;Ethyltrifluoropyruvate98%;ETHYL 3,3,3-TRIFLUORO-2-O;Threefluorideethylpyruvate;Ethyl trifluoropyruvate 98%;Ethyl-trifluoroMethylpyruvate
CBNumber: CB8333735
Molecular Formula: C5H5F3O3
Formula Weight: 170.09
MOL File: 13081-18-0.mol

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Ethyl trifluoropyruvate Property

Boiling point:: 42 °C(lit.)
Density: 1.283 g/mL at 25 °C (lit.)
vapor pressure: 12.49hPa at 25℃
refractive index: n20/D 1.341(lit.)
Flash point:: 88 °F
storage temp.: Inert atmosphere,2-8°C
solubility: Miscible with dichloromethane.
form: Liquid
color: Clear colorless to pale yellow
BRN: 2087388
Stability:: Moisture Sensitive
InChIKey: KJHQVUNUOIEYSV-UHFFFAOYSA-N
LogP: -0.05
CAS DataBase Reference: 13081-18-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,C,Xi
Risk Statements: 10-22-36/37/38
Safety Statements: 26-37/39-16
RIDADR: UN 3272 3/PG 3
WGK Germany: 3
Hazard Note: Corrosive
HazardClass: 3
PackingGroup: III
HS Code: 29183000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 510254
Product name: Ethyl 3,3,3-trifluoropyruvate
Purity: 97%
Packaging: 5g
Price: $26
Updated: 2024/03/01

TCI Chemical

Product number: T1434
Product name: Ethyl Trifluoropyruvate
Purity: >98.0%(GC)
Packaging: 5g
Price: $47
Updated: 2024/03/01

TCI Chemical

Product number: T1434
Product name: Ethyl Trifluoropyruvate
Purity: >98.0%(GC)
Packaging: 25g
Price: $135
Updated: 2024/03/01

Alfa Aesar

Product number: B20611
Product name: Ethyl trifluoropyruvate, 97%
Packaging: 5g
Price: $46.65
Updated: 2024/03/01

Alfa Aesar

Product number: B20611
Product name: Ethyl trifluoropyruvate, 97%
Packaging: 25g
Price: $184
Updated: 2024/03/01

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Ethyl trifluoropyruvate Chemical Properties,Usage,Production

Chemical Properties

Clear pale yellow liquid

Uses

Ethyl trifluoropyruvate acts as a building block in synthetic chemistry for the synthesis of fluorine containing compounds. It is also used as a reagent for the preparation of potential biologically active compounds like highly enantioselective organocatalytic hydroxyalkylation of indoles.

Uses

Ethyl 3,3,3-trifluoropyruvate may be used in the preparation of N-heteroaryl(trifluoromethyl)hydroxyalkanoic acid esters.

Uses

Ethyl Trifluoropyruvate is used as a reagent in the preparation of potential biologically active compounds such as in the highly enantioselective organocatalytic hydroxyalkylation of indoles .

General Description

Ethyl 3,3,3-trifluoropyruvate is a trifluoromethylated compound. Enantioselective Friedel–Crafts alkylation of simple phenols and indoles with ethyl 3,3,3-trifluoropyruvate under different reaction conditions have been reported.

Synthesis

To 58 mL (1.0 mL/mmol) of acetonitrile, 10 g (58 mmol, 1.0 eq) of ethyl 3,3,3-trifluorolactate was added and dissolved therein.Furthermore, 11 g (67 mmol, 1.2 eq) of NaClO.5H2O was added, followed by stirring at 20° C. for 30 minutes.As the reaction-terminated liquid was analyzed by 19F-NMR, conversion was 100%, and selectivity was 98%.To the reaction-terminated liquid, 0.38 g (1.5 mmol, 0.026 eq) of sodium thiosulfate pentahydrate was added, followed by stirring, thereby quenching the remaining oxidation agent.Furthermore, 0.33 g (3.9 mmol, 0.067 eq) of sodium hydrogencarbonate and 10 g (70 mmol, 1.2 eq) of sodium sulfate were added, followed by stirring and then removing solid matter by filtration.As the filtrate was quantified with internal standard method (internal standard substance: α,α,α-trifluorotoluene) by 19F-NMR, Ethyl trifluoropyruvate was contained by 56 mmol (quantitative yield: 97%).By a simple distillation (up to 48° C./0.5 kPa) of the filtrate, 7.6 g of Ethyl trifluoropyruvate was obtained. 19F-NMR purity was 99% (40 mmol), and the total yield was 69%.

Ethyl trifluoropyruvate Preparation Products And Raw materials

Raw materials

Preparation Products

6-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID 2-(TRIFLUOROMETHYL)-5,7-DIMETHYLQUINOLINE-4-CARBOXYLIC ACID 5-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID 2-(TRIFLUOROMETHYL)-5-METHYLQUINOLINE-4-CARBOXYLIC ACID

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View Lastest Price from Ethyl trifluoropyruvate manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: Ethyl trifluoropyruvate 13081-18-0
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2024-08-19

Henan Aochuang Chemical Co.,Ltd.

Product: Ethyl trifluoropyruvate 13081-18-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-16

Longyan Tianhua Biological Technology Co., Ltd

Product: Ethyl trifluoropyruvate 13081-18-0
Price: US $50.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KG
Release date: 2020-10-29

13081-18-0, Ethyl trifluoropyruvateRelated Search:

Ethyl 4,4,4-trifluoroacetoacetate Ethyl acetoacetate Phosphoenolpyruvate carboxylase Ethylparaben Ethyl bromopyruvate Calcium pyruvate Trinexapac-ethyl ISOXADIFEN-ETHYL PYRUVATE DEHYDROGENASE EC 2.7.1.40 Dimethyl succinate Methyl acrylate Ethanol Ethyl acetate Ethyl bromodifluoroacetate Ethyl propionate Ethyl trifluoroacetate Ethyl 2,4-dioxovalerate

Ethyl trifluoropyruvate, Ethyl 2-oxo-3,3,3-trifluoropropionate

Threefluorideethylpyruvate

Ethyl 3,3,3-trifluoropyruvate 97%

ETHYL TRIFLUOROPYRUVATE

ETHYL 3,3,3-TRIFLUOROPYRUVATE

ETHYL 3,3,3-TRIFLUORO-2-OXOPROPANOATE

ETHYL 2-OXO-3,3,3-TRIFLUORO PROPIONATE

E-TFPA

3,3,3-TRIFLUORO-2-OXOPROPANOIC ACID ETHYL ESTER

RARECHEM AL BI 1300

TRIFLUOROPYRUVIC ACID ETHYL ESTER

Ethyl trifluoropyruvate 98%

Ethyltrifluoropyruvate98%

3,3,3-Trifluoropyruvic acid ethyl ester

Ethyl 2-oxo-3,3,3-trifluoropropanoate

Ethyl 2-oxo-3,3,3-trifluoropropanoate 97%

ETHYL 3,3,3-TRIFLUORO-2-O

Ethyl 3,3,3-trifluoropyruvate,98+%

Ethyl-trifluoroMethylpyruvate

Propanoic acid, 3,3,3-trifluoro-2-oxo-, ethyl ester

3,3, 3-trifluoropyruvate, ethyl ester

TIANFUCHEM--13081-18-0--Ethyl trifluoropyruvate factory price

13081-18-0

3081-18-0

1308-18-0

C5H5F3O3

CF3COCO2C2H5

Esters

Organic Building Blocks

Carbonyl Compounds

C2 to C5

Building Blocks

C2 to C5

Carbonyl Compounds

Esters