Procainamide hydrochloride
- Product Name
- Procainamide hydrochloride
- CAS No.
- 614-39-1
- Chemical Name
- Procainamide hydrochloride
- Synonyms
- PROCAINAMIDE HCL;Pronestyl;Procapan;Procanbid;Promide;Amisalin;amidoprocain;TIMTEC-BB SBB001067;promidehydrochloride;ProcainaMide HCl USP
- CBNumber
- CB7139464
- Molecular Formula
- C13H22ClN3O
- Formula Weight
- 271.79
- MOL File
- 614-39-1.mol
Procainamide hydrochloride Property
- Melting point:
- 165-168 °C
- Density
- 1.2027 (rough estimate)
- refractive index
- 1.6330 (estimate)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble1g/10 mL, clear, greenish-yellow
- form
- Powder
- color
- White to slightly yellow
- Water Solubility
- soluble
- Sensitive
- Light Sensitive/Air Sensitive
- Merck
- 13,7845
- BRN
- 3729517
- CAS DataBase Reference
- 614-39-1(CAS DataBase Reference)
- EPA Substance Registry System
- Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-, monohydrochloride (614-39-1)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- CV2295000
- HS Code
- 29242990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML2088
- Product name
- Procainamide hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 250MG
- Price
- $131
- Updated
- 2024/03/01
- Product number
- SML2088
- Product name
- Procainamide hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 1G
- Price
- $530
- Updated
- 2024/03/01
- Product number
- PHR1252
- Product name
- Procainamide hydrochloride
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500mg
- Price
- $97.5
- Updated
- 2024/03/01
- Product number
- 1563502
- Product name
- Procainamide hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 24359
- Product name
- Procainamide (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Procainamide hydrochloride Chemical Properties,Usage,Production
Description
Procainamide (hydrochloride) (Item No. 24359) is an analytical reference standard categorized as a local anesthetic. This product is intended for research and forensic applications.
Chemical Properties
White to slightly yellow powder
Uses
Class I antiarrhythmic
Uses
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Uses
Procainamide hydrochloride (PAH) is suitable to investigate its binding behavior with human serum albumin and bovine serum albumin by fluorescence quenching study to understand the pharmacokinetic and pharmacodynamic mechanisms of PAH.
Definition
ChEBI: A hydrochloride which has procainamide as the amino component.
General Description
Procainamide hydrochloride,p-amino-N-[2-(diethylamino)ethyl]benzamidemonohydrochloride, procainamidium chloride (Pronestyl,Procan SR), has emerged as a major antiarrhythmic drug. Itwas developed in the course of research for compoundsstructurally similar to procaine, which had limited effectas an antiarrhythmic agent because of its central nervoussystem (CNS) side effects and short-lived action causedby rapid hydrolysis of its ester linkage by plasma esterases.Because of its amide structure, procainamide hydrochlorideis also more stable in water than is procaine. Aqueoussolutions of procainamide hydrochloride have a pH ofabout 5.5. A kinetic study of the acid-catalyzed hydrolysisof procainamide hydrochloride showed it to be unusuallystable to hydrolysis in the pH range 2 to 7, even at elevatedtemperatures.
Biochem/physiol Actions
Procainamide hydrochloride is a sodium channel blocker and Class IA anti-arrhythmic. It has also been shown to Inhibit DNA methyltransferase and modulate epigenetic regulation of gene expression.
Clinical Use
Procainamide hydrochloride is metabolized through theaction of N-acetyltransferase. The product of enzymaticmetabolism of procainamide hydrochloride is N-acetylprocainamide(NAPA), which possesses only 25% of the activityof the parent compound.26 A study of the disposition ofprocainamide hydrochloride showed that 50% of the drugwas excreted unchanged in the urine, with 7% to 24% recoveredas NAPA.28,29 Unlike quinidine, procainamide hydrochlorideis bound only minimally to plasma proteins.Between 75% and 95% of the drug is absorbed from the gastrointestinaltract. Plasma levels appear 20 to 30 minutesafter administration and peak in about 1 hour.30Procainamide hydrochloride appears to have all of theelectrophysiological effects of quinidine. It diminishesautomaticity, decreases conduction velocity, and increasesaction potential duration and, thereby, the refractory periodof myocardial tissue. Clinicians have favored the use of procainamidehydrochloride for ventricular tachycardias andquinidine for atrial arrhythmias, even though the two drugsare effective in either type of disorder.
Veterinary Drugs and Treatments
Procainamide potentially may be useful for the treatment of ventricular premature complexes (VPC’s), ventricular tachycardia, or supraventricular tachycardia associated with Wolff-Parkinson- White (WPW) syndrome with wide QRS complexes. Higher doses may be beneficial in the treatment of supraventricular tachycardias, although procainamide cannot be considered a first-line agent for this dysrhythmia.
Procainamide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Procainamide hydrochloride Suppliers
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View Lastest Price from Procainamide hydrochloride manufacturers
- Product
- Procainamide Hydrochloride 614-39-1
- Price
- US $8.00-5000.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 500tons
- Release date
- 2022-10-28
- Product
- Procainamide hydrochloride 614-39-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-13
- Product
- Procainamide hydrochloride 614-39-1
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-07-25