Procainamide hydrochloride

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Procainamide hydrochloride

Product Name: Procainamide hydrochloride
CAS No.: 614-39-1
Chemical Name: Procainamide hydrochloride
Synonyms: PROCAINAMIDE HCL;Pronestyl;Procapan;Procanbid;Promide;Amisalin;amidoprocain;TIMTEC-BB SBB001067;promidehydrochloride;ProcainaMide HCl USP
CBNumber: CB7139464
Molecular Formula: C13H22ClN3O
Formula Weight: 271.79
MOL File: 614-39-1.mol

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Procainamide hydrochloride Property

Melting point:: 165-168 °C
Density: 1.2027 (rough estimate)
refractive index: 1.6330 (estimate)
storage temp.: 2-8°C
solubility: H2O: soluble1g/10 mL, clear, greenish-yellow
form: Powder
color: White to slightly yellow
Water Solubility: soluble
Sensitive: Light Sensitive/Air Sensitive
Merck: 13,7845
BRN: 3729517
CAS DataBase Reference: 614-39-1(CAS DataBase Reference)
EPA Substance Registry System: Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-, monohydrochloride (614-39-1)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
RTECS: CV2295000
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2088
Product name: Procainamide hydrochloride
Purity: ≥98% (HPLC)
Packaging: 250MG
Price: $131
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2088
Product name: Procainamide hydrochloride
Purity: ≥98% (HPLC)
Packaging: 1G
Price: $530
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1252
Product name: Procainamide hydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500mg
Price: $97.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1563502
Product name: Procainamide hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Cayman Chemical

Product number: 24359
Product name: Procainamide (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

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Procainamide hydrochloride Chemical Properties,Usage,Production

Description

Procainamide (hydrochloride) (Item No. 24359) is an analytical reference standard categorized as a local anesthetic. This product is intended for research and forensic applications.

Chemical Properties

White to slightly yellow powder

Uses

Class I antiarrhythmic

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Uses

Procainamide hydrochloride (PAH) is suitable to investigate its binding behavior with human serum albumin and bovine serum albumin by fluorescence quenching study to understand the pharmacokinetic and pharmacodynamic mechanisms of PAH.

Definition

ChEBI: A hydrochloride which has procainamide as the amino component.

General Description

Procainamide hydrochloride,p-amino-N-[2-(diethylamino)ethyl]benzamidemonohydrochloride, procainamidium chloride (Pronestyl,Procan SR), has emerged as a major antiarrhythmic drug. Itwas developed in the course of research for compoundsstructurally similar to procaine, which had limited effectas an antiarrhythmic agent because of its central nervoussystem (CNS) side effects and short-lived action causedby rapid hydrolysis of its ester linkage by plasma esterases.Because of its amide structure, procainamide hydrochlorideis also more stable in water than is procaine. Aqueoussolutions of procainamide hydrochloride have a pH ofabout 5.5. A kinetic study of the acid-catalyzed hydrolysisof procainamide hydrochloride showed it to be unusuallystable to hydrolysis in the pH range 2 to 7, even at elevatedtemperatures.

Biochem/physiol Actions

Procainamide hydrochloride is a sodium channel blocker and Class IA anti-arrhythmic. It has also been shown to Inhibit DNA methyltransferase and modulate epigenetic regulation of gene expression.

Clinical Use

Procainamide hydrochloride is metabolized through theaction of N-acetyltransferase. The product of enzymaticmetabolism of procainamide hydrochloride is N-acetylprocainamide(NAPA), which possesses only 25% of the activityof the parent compound.26 A study of the disposition ofprocainamide hydrochloride showed that 50% of the drugwas excreted unchanged in the urine, with 7% to 24% recoveredas NAPA.28,29 Unlike quinidine, procainamide hydrochlorideis bound only minimally to plasma proteins.Between 75% and 95% of the drug is absorbed from the gastrointestinaltract. Plasma levels appear 20 to 30 minutesafter administration and peak in about 1 hour.30Procainamide hydrochloride appears to have all of theelectrophysiological effects of quinidine. It diminishesautomaticity, decreases conduction velocity, and increasesaction potential duration and, thereby, the refractory periodof myocardial tissue. Clinicians have favored the use of procainamidehydrochloride for ventricular tachycardias andquinidine for atrial arrhythmias, even though the two drugsare effective in either type of disorder.

Veterinary Drugs and Treatments

Procainamide potentially may be useful for the treatment of ventricular premature complexes (VPC’s), ventricular tachycardia, or supraventricular tachycardia associated with Wolff-Parkinson- White (WPW) syndrome with wide QRS complexes. Higher doses may be beneficial in the treatment of supraventricular tachycardias, although procainamide cannot be considered a first-line agent for this dysrhythmia.

Procainamide hydrochloride Preparation Products And Raw materials

Raw materials

4-AMINO-N-[2-(DIETHYLAMINO)ETHYL]BENZAMIDE 4-Nitrobenzoyl chloride Ethylbenzene Diethylamino-ethylamine Benzamide

Preparation Products

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View Lastest Price from Procainamide hydrochloride manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Procainamide hydrochloride 614-39-1
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-21

Apeloa production Co.,Limited

Product: ProcainaMide hydrochloride 614-39-1
Price: US $1.00/g
Min. Order: 1g
Purity: 0.98
Supply Ability: 1000
Release date: 2024-07-18

Shaanxi Dideu New Materials Co. Ltd

Product: Procainamide hydrochloride 614-39-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000KG
Release date: 2024-11-09

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procan-srhydrochloride

procapanhydrochloride

procardylhydrochloride

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Procanbid

Procapan

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Procainamide hydrochloride USP/EP/BP

Procainamide Hydrochloride (1563502)

Promide

Procapan|||Procainamide HCl|||Pronestyl|||Procanbid

Procainamide-HCl in Methanol

C16289480 ProcainamidEHydrochloride

614-39-1

699-39-0

C13H21N3OHClC13H22ClN3O

H2NC6H4CONHCH2CH2NC2H52HCl

C13H21N3OHCl

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