ChemicalBook > CAS DataBase List > 2,4-Dichloro-5-pyrimidinecarbonyl chloride

2,4-Dichloro-5-pyrimidinecarbonyl chloride

Product Name
2,4-Dichloro-5-pyrimidinecarbonyl chloride
CAS No.
2972-52-3
Chemical Name
2,4-Dichloro-5-pyrimidinecarbonyl chloride
Synonyms
2,4-Dichloropyrimidine-5-carbonyl chloride;RSYY（Avanafil)-46;5-(Chlorocarbonyl)-2,4-dichlo;2,4-dichloro-5-pyrimidinyl chloride;2,4-Dichloro-5-pyrimidinecarbonylchloride;5-(Chlorocarbonyl)-2,4-dichloropyrimidine;2,3-Dichloro-5-pyrimidine carbonyl chloride;5-Pyrimidinecarbonyl chloride, 2,4-dichloro-;2,4-DichloropyriMidine-5-carbonyl chloride 97%;2,4-Dichloro-5-pyrimidinecarboxylic acid chloride
CBNumber
CB7956663
Molecular Formula
C5HCl3N2O
Formula Weight
211.43
MOL File
2972-52-3.mol
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2,4-Dichloro-5-pyrimidinecarbonyl chloride Property

Boiling point:
83 °C(Press: 0.05 Torr)
Density 
1.645 g/mL at 25 °C
refractive index 
n20/D1.586
Flash point:
93℃
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
liquid
pka
-5.08±0.29(Predicted)
color 
Clear, colourless
InChI
InChI=1S/C5HCl3N2O/c6-3-2(4(7)11)1-9-5(8)10-3/h1H
InChIKey
DZTIFMWYYHCREC-UHFFFAOYSA-N
SMILES
C(Cl)(C1=CN=C(Cl)N=C1Cl)=O
CAS DataBase Reference
2972-52-3(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
20/21/22-34
Safety Statements 
6-7/9-24/25-26-36/37/39-51
RIDADR 
3265
WGK Germany 
3
HazardClass 
IRRITANT, CORROSIVE
PackingGroup 
Ⅲ
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
728772
Product name
2,4-Dichloropyrimidine-5-carbonyl chloride
Purity
97%
Packaging
500mg
Price
$74.36
Updated
2025/07/31
Usbiological
Product number
270845
Product name
2,3-Dichloro-5-pyrimidine carbonyl chloride
Packaging
1g
Price
$433
Updated
2021/12/16
SynQuest Laboratories
Product number
4H16-5-Y1
Product name
2,4-Dichloropyrimidine-5-carbonyl chloride
Packaging
250mg
Price
$64
Updated
2021/12/16
Matrix Scientific
Product number
032528
Product name
2,4-Dichloropyrimidine-5-carbonyl chloride
Purity
97%
Packaging
1g
Price
$103
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD08253
Product name
2,3-Dichloro-5-pyrimidine carbonyl chloride
Packaging
1g
Price
$131.3
Updated
2021/12/16
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2,4-Dichloro-5-pyrimidinecarbonyl chloride Chemical Properties,Usage,Production

Synthesis

23945-44-0

2972-52-3

The general procedure for the synthesis of 2,4-dichloro-5-pyrimidinecarbonyl chloride from uracil-5-carboxylic acid is as follows: 9.1 Preparation of 2,4-dihydroxypyrimidine-5-carbonyl chloride In a 250 mL round bottom flask, 10.0 g (64.0 mmol) of 2,4-dihydroxypyrimidine-5-carboxylic acid was dissolved in 46 mL (500.0 mmol) of phosphorus oxychloride (POCl3) under nitrogen protection. The reaction mixture was cooled to 0°C via an ice bath, followed by the batch addition of 47.7 g (230 mmol) phosphorus pentachloride (PCl5). The reaction solution was heated and stirred at reflux for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in 100 mL of toluene and ground, followed by filtration. After this operation was repeated three times, the filtrate was evaporated under reduced pressure to give 13.5 g (64.0 mmol) of the yellow oily product 2,4-dichloro-5-pyrimidinecarbonyl chloride, which was used directly in the next step of the reaction. Yield = 100%.

References

[1] Patent: US2011/251194, 2011, A1. Location in patent: Page/Page column 21
[2] Patent: US2010/222319, 2010, A1. Location in patent: Page/Page column 18
[3] Patent: WO2015/21149, 2015, A1. Location in patent: Page/Page column 56; 57
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 6, p. 2746 - 2763
[5] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 55

2,4-Dichloro-5-pyrimidinecarbonyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-Dichloro-5-pyrimidinecarbonyl chloride manufacturers

Career Henan Chemical Co
Product
2,4-Dichloro-5-pyrimidinecarbonyl chloride 2972-52-3
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2019-12-30

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  • 2,4-DichloropyriMidine-5-carbonyl chloride 97%
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  • 5-Pyrimidinecarbonyl chloride, 2,4-dichloro-
  • RSYY（Avanafil)-46
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