2,4,6-Trichloropyridine
- Product Name
- 2,4,6-Trichloropyridine
- CAS No.
- 16063-69-7
- Chemical Name
- 2,4,6-Trichloropyridine
- Synonyms
- 2,4,6-trichloro-pyridin;2,4,6-Trichloropyridine;Pyridine,2,4,6-trichloro-;2 4 6-TRICHLOROPYRIDINE 97;2,4,6-Trichloropyridine,98%;2,4,6-Trichloropyridine ISO 9001：2015 REACH
- CBNumber
- CB7498770
- Molecular Formula
- C5H2Cl3N
- Formula Weight
- 182.44
- MOL File
- 16063-69-7.mol
2,4,6-Trichloropyridine Property
- Melting point:
- 33-37 °C (lit.)
- Boiling point:
- 217.5-218.5 °C
- Density
- 1.539±0.06 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- pka
- -2.93±0.10(Predicted)
- form
- Crystalline Powder
- color
- Yellow to yellow-brown
- Water Solubility
- Sparingly soluble in water. (0.113 mm Hg at 25°C)
- InChI
- InChI=1S/C5H2Cl3N/c6-3-1-4(7)9-5(8)2-3/h1-2H
- InChIKey
- FJNNGKMAGDPVIU-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC(Cl)=C1
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-41-43
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- RTECS
- UU0875000
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 633534
- Product name
- 2,4,6-Trichloropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $386.5
- Updated
- 2025/07/31
- Product number
- 633534
- Product name
- 2,4,6-Trichloropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $230
- Updated
- 2023/01/07
- Product number
- T3395
- Product name
- 2,4,6-Trichloropyridine
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $91
- Updated
- 2025/07/31
- Product number
- T3395
- Product name
- 2,4,6-Trichloropyridine
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $272
- Updated
- 2025/07/31
- Product number
- T895950
- Product name
- 2,4,6-Trichloropyridine
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
2,4,6-Trichloropyridine Chemical Properties,Usage,Production
Chemical Properties
White to off-white crystals or crystalline solid
Uses
2,4,6-Trichloropyridine is used as pharmaceutical intermediates.
Synthesis
2587-00-0
16063-69-7
2,6-Dichloropyridine-N-oxide (Y-2) (8.20 g, 0.050 mol) was used as a raw material, which was dissolved in phosphorus trichloride (POCl3, 25 mL) and the reaction was carried out at reflux for 4 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was carefully poured into crushed ice and extracted with petroleum ether (3 x 50 mL). The organic phases were combined, dried with anhydrous potassium carbonate (K2CO3), filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography using a mixed solvent of ethyl acetate/petroleum ether as eluent, resulting in colorless needle-like crystals of 2,4,6-trichloropyridine (Y-3) in 85% yield with a melting point of 32-33 °C. The final product was extracted from the crude product using a mixture of ethyl acetate/petroleum ether as eluent, and then dried with anhydrous potassium carbonate (3 × 50 mL).
References
[1] European Journal of Medicinal Chemistry, 2016, vol. 109, p. 294 - 304
[2] Patent: CN105294550, 2016, A. Location in patent: Paragraph 0045; 0048
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 2051 - 2060
[4] Chemical & Pharmaceutical Bulletin, 1986, vol. 34, # 9, p. 3658 - 3671
[5] Angewandte Chemie - International Edition, 2016, vol. 55, # 40, p. 12321 - 12324
2,4,6-Trichloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4,6-Trichloropyridine manufacturers
- Product
- 2,4,6-Trichloropyridine 16063-69-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-07
- Product
- 2,4,6-Trichloropyridine 16063-69-7
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 2,4,6-Trichloropyridine 16063-69-7
- Price
- US $390.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-02-19