2,4,6-Trichloropyrimidine
- Product Name
- 2,4,6-Trichloropyrimidine
- CAS No.
- 3764-01-0
- Chemical Name
- 2,4,6-Trichloropyrimidine
- Synonyms
- 2,4,6-TRICHLOROPYRIDINE;TrichloropyriMidine;TCPY;2,4,6-trichloro-pyrimidin;NSC 6494;AURORA KA-4834;2,4,6-TrichloropyriM;Xamoterol Impurity 3;6-TrichloropyriMidine;2,4,6-TRICHLOROPYRIMIDINE
- CBNumber
- CB6466644
- Molecular Formula
- C4HCl3N2
- Formula Weight
- 183.42
- MOL File
- 3764-01-0.mol
2,4,6-Trichloropyrimidine Property
- Melting point:
- 23-25 °C (lit.)
- Boiling point:
- 210-215 °C (lit.)
- Density
- 1.595 g/mL at 20 °C (lit.)
- refractive index
- n20/D 1.57(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Ethyl Acetate
- form
- Liquid After Melting
- pka
- -7.14±0.30(Predicted)
- color
- Clear colorless to yellow
- Water Solubility
- Insoluble in water.
- FreezingPoint
- 21.0 to 23.0 ℃
- BRN
- 118284
- InChIKey
- DPVIABCMTHHTGB-UHFFFAOYSA-N
- CAS DataBase Reference
- 3764-01-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyrimidine, 2,4,6-trichloro-(3764-01-0)
- EPA Substance Registry System
- Pyrimidine, 2,4,6-trichloro- (3764-01-0)
Safety
- Hazard Codes
- Xn,Xi,T
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36-24/25-23
- RIDADR
- UN1759
- WGK Germany
- 3
- TSCA
- T
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T56200
- Product name
- 2,4,6-Trichloropyrimidine
- Purity
- 97%
- Packaging
- 25g
- Price
- $85.9
- Updated
- 2025/07/31
- Product number
- T0417
- Product name
- 2,4,6-Trichloropyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $107
- Updated
- 2025/07/31
- Product number
- T0417
- Product name
- 2,4,6-Trichloropyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $1008
- Updated
- 2025/07/31
- Product number
- T774180
- Product name
- 2,4,6-Trichloropyrimidine
- Packaging
- 250g
- Price
- $345
- Updated
- 2021/12/16
- Product number
- T774180
- Product name
- 2,4,6-Trichloropyrimidine
- Packaging
- 500g
- Price
- $575
- Updated
- 2021/12/16
2,4,6-Trichloropyrimidine Chemical Properties,Usage,Production
Chemical Properties
clear colorless to yellowish liquid after melting
Uses
Fungitoxic substance.
Uses
It is applied In selective Suzuki coupling with arylboronic acids has been reported to give 6-arylpyrimidines.
Synthesis Reference(s)
Journal of the American Chemical Society, 80, p. 5481, 1958 DOI: 10.1021/ja01553a042
Synthesis
67-52-7
3764-01-0
Example 2: 128.1 g (1 mol) of barbituric acid and 500 ml (5.5 mol) of phosphorus trichloride were sequentially added to a reaction flask, heated to reflux and maintained for 4 hours. Subsequently, 270 ml (3.1 mol) of phosphorus trichloride and 213 g (3 mol) of chlorine were slowly added dropwise to the reaction system, and the reaction solution was kept as a light yellow suspension during the treatment. The amount of chlorine gas should be strictly controlled during the titration process to avoid overdose, and the specific operation was referred to Example 1. After the titration was completed, the reaction was continued to reflux for 1 hour. After completion of the reaction, phosphorus trichloride is removed by distillation. Finally, 2,4,6-trichloropyrimidine was obtained by distillation under pump vacuum according to the method described in Example 1. The yield of the product was 148 g, the yield was 81% of the theoretical value (in terms of barbituric acid), and the absence of 2,4,5,6-tetrachloropyrimidine in the product was confirmed by GC assay.
Toxics Screening Level
The initial threshold screening level (ITSL) for 2,4,6-trichloropyrimidine is 0.1 μg/m3 based on an annual averaging time.
References
[1] Journal of the American Chemical Society, 1980, vol. 102, # 15, p. 5036 - 5044
[2] Patent: US5898073, 1999, A
[3] Patent: US5712394, 1998, A
[4] Polyhedron, 2014, vol. 81, p. 316 - 322
[5] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 159 - 174
2,4,6-Trichloropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4,6-Trichloropyrimidine manufacturers
- Product
- 2,4,6-Trichloropyrimidine 3764-01-0
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-12
- Product
- 2,4,6-Trichloropyrimidine 3764-01-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- 2,4,6-Trichloropyrimidine 3764-01-0
- Price
- US $10.00-3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-26