2,4,5-Trichloropyrimidine
- Product Name
- 2,4,5-Trichloropyrimidine
- CAS No.
- 5750-76-5
- Chemical Name
- 2,4,5-Trichloropyrimidine
- Synonyms
- 2,4,5-TrichL;2,4,5-Trichloropyrim;2,5,6-TRICHLOROPYRIMIDINE;2,4,5-TRICHLOROPYRIMIDINE;2,4,5-Trichloro-1,3-diazine;2,4,5-three chloropyriMidine;Pyrimidine, 2,4,5-trichloro-;2,4,5-TrichloropyriMidine 99%;2,4,5-Trichloropyrimidine ,98%;2,4,5-Trichloropyrimidine, 99+%
- CBNumber
- CB0387545
- Molecular Formula
- C4HCl3N2
- Formula Weight
- 183.42
- MOL File
- 5750-76-5.mol
2,4,5-Trichloropyrimidine Property
- Boiling point:
- 84°C 1mm
- Density
- 1.6001 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.574(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- clear liquid
- pka
- -4.26±0.29(Predicted)
- color
- Colorless to Light orange to Yellow
- Water Solubility
- Not miscible or difficult to mix in water.
- BRN
- 4449
- InChI
- InChI=1S/C4HCl3N2/c5-2-1-8-4(7)9-3(2)6/h1H
- InChIKey
- GIKMWFAAEIACRF-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(Cl)C(Cl)=N1
- CAS DataBase Reference
- 5750-76-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 652032
- Product name
- 2,4,5-Trichloropyrimidine
- Purity
- 99%
- Packaging
- 1g
- Price
- $67.2
- Updated
- 2025/07/31
- Product number
- 652032
- Product name
- 2,4,5-Trichloropyrimidine
- Purity
- 99%
- Packaging
- 5g
- Price
- $162
- Updated
- 2025/07/31
- Product number
- T2512
- Product name
- 2,4,5-Trichloropyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $80
- Updated
- 2025/07/31
- Product number
- T2512
- Product name
- 2,4,5-Trichloropyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $266
- Updated
- 2025/07/31
- Product number
- T774320
- Product name
- 2,4,5-Trichloropyrimidine
- Packaging
- 5g
- Price
- $165
- Updated
- 2021/12/16
2,4,5-Trichloropyrimidine Chemical Properties,Usage,Production
Chemical Properties
Colorless to pale yellow liquid
Uses
2,4,5-Trichloropyrimidine is used in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment. Also used in the synthesis of EGFR inhibitors.
Synthesis
1820-81-1
5750-76-5
General procedure for the synthesis of 2,4,5-trichloropyrimidine from 5-chlorouracil: 5-chlorouracil (4.5 g, 30.82 mmol) was dissolved in phosphorochloridic acid (100 mL), followed by phosphorus pentachloride (19.2 g, 92.46 mmol). The reaction mixture was heated to reflux overnight; after completion of the reaction, it was cooled to room temperature and the solvent was removed by evaporation under reduced pressure. The residue was cooled to 0 °C and crushed ice was added slowly. The mixture was stirred for 10 min and partitioned between water and dichloromethane (DCM). The organic phase was separated and washed three times with water. The aqueous layer was combined and extracted twice with DCM. The combined organic extracts were dried over anhydrous sodium sulfate (Na2SO4), filtered and the solvent was evaporated under reduced pressure to give 2,4,5-trichloropyrimidine as a yellow oil, which did not require further purification.
References
[1] Patent: WO2008/28860, 2008, A1. Location in patent: Page/Page column 45
[2] Patent: US2006/25433, 2006, A1. Location in patent: Page/Page column 108
[3] Patent: US4299961, 1981, A
[4] Patent: WO2008/79719, 2008, A1. Location in patent: Page/Page column 43-44; 47-48; 49; 51
[5] Patent: WO2007/120339, 2007, A1. Location in patent: Page/Page column 39-42
2,4,5-Trichloropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4,5-Trichloropyrimidine manufacturers
- Product
- 2,4,5-Trichloropyrimidine 5750-76-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2025-08-19
- Product
- 2,4,5-Trichloropyrimidine 5750-76-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-04
- Product
- 2,4,5-Trichloropyrimidine 5750-76-5
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-05