ChemicalBook > CAS DataBase List > 2,4,6-Trichloropyrimidine

2,4,6-Trichloropyrimidine

Product Name
2,4,6-Trichloropyrimidine
CAS No.
3764-01-0
Chemical Name
2,4,6-Trichloropyrimidine
Synonyms
2,4,6-TRICHLOROPYRIDINE;TrichloropyriMidine;TCPY;2,4,6-trichloro-pyrimidin;NSC 6494;AURORA KA-4834;2,4,6-TrichloropyriM;Xamoterol Impurity 3;6-TrichloropyriMidine;2,4,6-TRICHLOROPYRIMIDINE
CBNumber
CB6466644
Molecular Formula
C4HCl3N2
Formula Weight
183.42
MOL File
3764-01-0.mol
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2,4,6-Trichloropyrimidine Property

Melting point:
23-25 °C (lit.)
Boiling point:
210-215 °C (lit.)
Density 
1.595 g/mL at 20 °C (lit.)
refractive index 
n20/D 1.57(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform, Ethyl Acetate
form 
Liquid After Melting
pka
-7.14±0.30(Predicted)
color 
Clear colorless to yellow
Water Solubility 
Insoluble in water.
FreezingPoint 
21.0 to 23.0 ℃
BRN 
118284
InChIKey
DPVIABCMTHHTGB-UHFFFAOYSA-N
CAS DataBase Reference
3764-01-0(CAS DataBase Reference)
NIST Chemistry Reference
Pyrimidine, 2,4,6-trichloro-(3764-01-0)
EPA Substance Registry System
Pyrimidine, 2,4,6-trichloro- (3764-01-0)
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Safety

Hazard Codes 
Xn,Xi,T
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-24/25-23
RIDADR 
UN1759
WGK Germany 
3
TSCA 
T
HazardClass 
8
PackingGroup 
III
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T56200
Product name
2,4,6-Trichloropyrimidine
Purity
97%
Packaging
25g
Price
$85.9
Updated
2025/07/31
TCI Chemical
Product number
T0417
Product name
2,4,6-Trichloropyrimidine
Purity
>98.0%(GC)
Packaging
25g
Price
$107
Updated
2025/07/31
TCI Chemical
Product number
T0417
Product name
2,4,6-Trichloropyrimidine
Purity
>98.0%(GC)
Packaging
500g
Price
$1008
Updated
2025/07/31
TRC
Product number
T774180
Product name
2,4,6-Trichloropyrimidine
Packaging
250g
Price
$345
Updated
2021/12/16
TRC
Product number
T774180
Product name
2,4,6-Trichloropyrimidine
Packaging
500g
Price
$575
Updated
2021/12/16
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2,4,6-Trichloropyrimidine Chemical Properties,Usage,Production

Chemical Properties

clear colorless to yellowish liquid after melting

Uses

Fungitoxic substance.

Uses

It is applied In selective Suzuki coupling with arylboronic acids has been reported to give 6-arylpyrimidines.

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 5481, 1958 DOI: 10.1021/ja01553a042

Synthesis

67-52-7

3764-01-0

Example 2: 128.1 g (1 mol) of barbituric acid and 500 ml (5.5 mol) of phosphorus trichloride were sequentially added to a reaction flask, heated to reflux and maintained for 4 hours. Subsequently, 270 ml (3.1 mol) of phosphorus trichloride and 213 g (3 mol) of chlorine were slowly added dropwise to the reaction system, and the reaction solution was kept as a light yellow suspension during the treatment. The amount of chlorine gas should be strictly controlled during the titration process to avoid overdose, and the specific operation was referred to Example 1. After the titration was completed, the reaction was continued to reflux for 1 hour. After completion of the reaction, phosphorus trichloride is removed by distillation. Finally, 2,4,6-trichloropyrimidine was obtained by distillation under pump vacuum according to the method described in Example 1. The yield of the product was 148 g, the yield was 81% of the theoretical value (in terms of barbituric acid), and the absence of 2,4,5,6-tetrachloropyrimidine in the product was confirmed by GC assay.

Toxics Screening Level

The initial threshold screening level (ITSL) for 2,4,6-trichloropyrimidine is 0.1 μg/m3 based on an annual averaging time.

References

[1] Journal of the American Chemical Society, 1980, vol. 102, # 15, p. 5036 - 5044
[2] Patent: US5898073, 1999, A
[3] Patent: US5712394, 1998, A
[4] Polyhedron, 2014, vol. 81, p. 316 - 322
[5] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 159 - 174

2,4,6-Trichloropyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

4-AMINO-2,6-DIFLUOROPYRIMIDINE 4,6-DIMETHOXYPYRIMIDINE-2-SULFONYL CHLORIDE 2-ISOTHIOCYANATO-4,6-DIMETHOXYPYRIMIDINE 2,4-DIAMINO-6-FLUOROPYRIMIDINE 2-AMINO-4,6-DIFLUOROPYRIMIDINE
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View Lastest Price from 2,4,6-Trichloropyrimidine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
2,4,6-Trichloropyrimidine 3764-01-0
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-11-12
Henan Aochuang Chemical Co.,Ltd.
Product
2,4,6-Trichloropyrimidine 3764-01-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14
Henan Fengda Chemical Co., Ltd
Product
2,4,6-Trichloropyrimidine 3764-01-0
Price
US $10.00-3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-26

3764-01-0, 2,4,6-TrichloropyrimidineRelated Search:

Trichloroacetic acid Sucralose Trichlorosilane Sulfadiazine Trichloroethylene Trichloroisocyanuric acid 2,4,6-Trichloropyridine,2 4 6-TRICHLOROPYRIDINE 97 2,4,6-TRICHLORO-PYRIMIDINE-5-CARBALDEHYDE 2,4,6-TRICHLORO-5-NITROPYRIMIDINE Chloroform 5-Methyl-2,4,6-trichloropyrimidine 2,4,5,6-TETRACHLOROPYRIMIDINE 2,4,5-TRICHLOROPYRIMIDINE, 97+%,2,4,5-Trichloropyrimidine, 99+%,2,4,5-TRICHLOROPYRIMIDINE,2,5,6-TRICHLOROPYRIMIDINE Picloram 2,3,6-Trichloropyridine 4,5,6-TRICHLOROPYRIMIDINE 2-HYDOXY-3,5,6-TRICHLOROPYRIDINE 3,4,5-TRICHLOROPYRIDINE

  • 2,4,6-trichloro-pyrimidin
  • AURORA KA-4834
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  • 2,4,6-Trichloropyrimidine,98%
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  • Xamoterol Impurity 3
  • 2,4,6-Trichloropyrimidine, 98%min
  • 3764-01-0
  • C4Cl3H1N2
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