Raltitrexed
- Product Name
- Raltitrexed
- CAS No.
- 112887-68-0
- Chemical Name
- Raltitrexed
- Synonyms
- Tomudex;TDX;D1694;CS-664;ZD-1694;Retitrose;ICI-D-1694;ZEN-D-1694;Raltirexed;Raltitrexe
- CBNumber
- CB1222070
- Molecular Formula
- C21H22N4O6S
- Formula Weight
- 458.49
- MOL File
- 112887-68-0.mol
Raltitrexed Property
- Melting point:
- 176-1800C
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- H2O: ≥10mg/mL
- pka
- 3.50±0.10(Predicted)
- form
- solid
- color
- off-white to light yellow
- InChIKey
- IVTVGDXNLFLDRM-HNNXBMFYSA-N
- CAS DataBase Reference
- 112887-68-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 36/38-25-61
- Safety Statements
- 26-37/39-45-53
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 2
- HS Code
- 2934.99.4700
N-Bromosuccinimide Price
- Product number
- R9156
- Product name
- Raltitrexed monohydrate
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $158
- Updated
- 2024/03/01
- Product number
- R9156
- Product name
- Raltitrexed monohydrate
- Purity
- ≥98% (HPLC), solid
- Packaging
- 50mg
- Price
- $628
- Updated
- 2024/03/01
- Product number
- R0208
- Product name
- Raltitrexed
- Purity
- >98.0%(HPLC)
- Packaging
- 50mg
- Price
- $310
- Updated
- 2024/03/01
- Product number
- R0208
- Product name
- Raltitrexed
- Purity
- >98.0%(HPLC)
- Packaging
- 250mg
- Price
- $1081
- Updated
- 2024/03/01
- Product number
- 26079
- Product name
- Raltitrexed
- Packaging
- 10mg
- Price
- $62
- Updated
- 2024/03/01
Raltitrexed Chemical Properties,Usage,Production
Description
Tomudex was launched in Ireland, France, Luxembourg and the UK for advanced colorectal cancer and it was prepared in a convergent manner (6 steps) from diethyl L-glutamate and 6-bromomethyi-2-methyl-quinazolin4(3H)-one. Tomudex is a highly selective inhibitor of thymidylate synthase (TS), the key enzyme in the biochemical conversion of dUMP to dTMP. It enters the cell via the reduced folatefmethotrexate cell membrane carrier and is converted to the polyglutamate species by folylpolyglutamate synthase within 4h where it then binds to the folate substrate site of TS. Clinically, it had a 29% response rate in patients with advanced colorectal cancer. It is water soluble, can be administered as a single dose every three weeks and had no hepto- or nephrotoxicity.
Chemical Properties
Yellow Crystalline Powder
Originator
Zeneca (UK)
Uses
Folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. Antineoplastic
Definition
ChEBI: ICI D1694 is a N-acyl-amino acid.
brand name
Tomudex (Zeneca).
Biochem/physiol Actions
Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.
Clinical Use
Treatment of colorectal cancer when fluorouracil and folinic acid cannot be used
Drug interactions
Potentially hazardous interactions with other drugs
Antipsychotics: avoid with clozapine, increased risk
of agranulocytosis.
Folic and folinic acid: impairs cytotoxic action -
avoid.
Metabolism
Raltitrexed is actively transported into cells and
metabolised to active polyglutamate forms.
The remainder of a dose is not metabolised and is
excreted unchanged, about 50% of a dose appearing in the
urine, and about 15% in the faeces.
Raltitrexed Preparation Products And Raw materials
Raw materials
Preparation Products
Raltitrexed Suppliers
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View Lastest Price from Raltitrexed manufacturers
- Product
- Raltitrexed 112887-68-0
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 90%+
- Supply Ability
- 10g
- Release date
- 2021-09-20
- Product
- Raltitrexed 112887-68-0
- Price
- US $110.00-90.00/kilogram
- Min. Order
- 1kilogram
- Purity
- 99%
- Supply Ability
- 10 tons/per week
- Release date
- 2023-12-27
- Product
- Raltitrexed 112887-68-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%, Single impurity＜0.1
- Supply Ability
- 1 ton
- Release date
- 2023-12-26