Enalapril
- Product Name
- Enalapril
- CAS No.
- 75847-73-3
- Chemical Name
- Enalapril
- Synonyms
- Vasotec;Renitec;G1ioten;Hipoartd;ENALAPRIL;Enalapril hydrate;Enalapril (MK-421);ELAPRILAT DIHYDRAT;Enalapril USP/EP/BP;Enalapril AldrichCPR
- CBNumber
- CB1295108
- Molecular Formula
- C20H28N2O5
- Formula Weight
- 376.45
- MOL File
- 75847-73-3.mol
Enalapril Property
- Melting point:
- 142-147℃
- Boiling point:
- 582.4±50.0 °C(Predicted)
- Density
- 1.204±0.06 g/cm3(Predicted)
- RTECS
- TW3665500
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- pKa 2.97 (H2O t=25.0)(Approximate);5.35(H2O t=25.0)(Approximate)
- Water Solubility
- Soluble in water at 25mg/ml
- BCS Class
- 3
- CAS DataBase Reference
- 75847-73-3(CAS DataBase Reference)
- EPA Substance Registry System
- L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl- (75847-73-3)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- Hazardous Substances Data
- 75847-73-3(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- J60750
- Product name
- Enalapril
- Packaging
- 1g
- Price
- $93.65
- Updated
- 2024/03/01
- Product number
- J60750
- Product name
- Enalapril
- Packaging
- 5g
- Price
- $369.65
- Updated
- 2024/03/01
- Product number
- 16041
- Product name
- Enalapril
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- 16041
- Product name
- Enalapril
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 16041
- Product name
- Enalapril
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $30
- Updated
- 2021/12/16
Enalapril Chemical Properties,Usage,Production
Uses
angiotensin converting enzyme inhibitor
Uses
It is used for hypertension and chronic cardiac insufficiency.
Uses
Enalapril is used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. It has been proven to protect the function of the kidneys in hypertension, heart failure, and diabetes, and may be used in the absence of hypertension for its kidney protective effects. It is widely used in chronic kidney failure.
Definition
ChEBI: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
Mechanism of action
Like captopril, enalapril selectively suppresses the rennin–angiotensin–aldosterone system, inhibits angiotensin-converting enzyme, and prevents conversion of angiotensin I into angiotensin II.
Synthesis
Enalapril, (S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline (22.7.12), is synthesized by reacting the benzyl ester of L-alanyl-L-proline with the ethyl ester of 3-benzoylacrylic acid, which forms the product 22.7.11, the reduction of which with hydrogen using a Raney nickel catalyst removes the protective benzyl group, giving the desired enalapril (22.7.12) [24]. Alternative methods of syntheses have also been proposed.
Enalapril Preparation Products And Raw materials
Raw materials
Preparation Products
View Lastest Price from Enalapril manufacturers
- Product
- Enalapril 75847-73-3
- Price
- US $200.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 9000kg/per week
- Release date
- 2021-09-02
- Product
- Enalapril 75847-73-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Enalapril 75847-73-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-10