ChemicalBook > CAS DataBase List > cis-4-Hydroxy-L-proline

cis-4-Hydroxy-L-proline

Product Name
cis-4-Hydroxy-L-proline
CAS No.
618-27-9
Chemical Name
cis-4-Hydroxy-L-proline
Synonyms
(2S,4S)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;H-CIS-HYP-OH;CIS-4-HYDROXYPROLINE;CIS-HYP-OH;cis-Hydroxy-L-proline;(4S)-4-hydroxypyrrolidine-2-carboxylic acid;CHYP;cis L;cis-L-Hyp-OH;H-L-CIS-HYP-OH
CBNumber
CB6158895
Molecular Formula
C5H9NO3
Formula Weight
131.13
MOL File
618-27-9.mol
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cis-4-Hydroxy-L-proline Property

Melting point:
257 °C (dec.) (lit.)
alpha 
-59 º (c=2, H2O)
Boiling point:
242.42°C (rough estimate)
Density 
1.3121 (rough estimate)
refractive index 
-59 ° (C=2, H2O)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble
pka
2.14±0.40(Predicted)
form 
Powder
color 
White to beige
Water Solubility 
soluble
Merck 
14,4840
BRN 
81440
InChIKey
PMMYEEVYMWASQN-IMJSIDKUSA-N
CAS DataBase Reference
618-27-9(CAS DataBase Reference)
EPA Substance Registry System
L-Proline, 4-hydroxy-, (4S)- (618-27-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36/37/39-27-26
WGK Germany 
3
10
TSCA 
Yes
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H1637
Product name
cis-4-Hydroxy-L-proline
Purity
collagen synthesis inhibitor
Packaging
50mg
Price
$79.9
Updated
2024/03/01
Sigma-Aldrich
Product number
H1637
Product name
cis-4-Hydroxy-L-proline
Purity
collagen synthesis inhibitor
Packaging
1g
Price
$1050
Updated
2024/03/01
TCI Chemical
Product number
H1169
Product name
cis-4-Hydroxy-L-proline
Purity
>97.0%(T)
Packaging
100mg
Price
$68
Updated
2024/03/01
TCI Chemical
Product number
H1169
Product name
cis-4-Hydroxy-L-proline
Purity
>97.0%(T)
Packaging
1g
Price
$327
Updated
2024/03/01
Alfa Aesar
Product number
H27194
Product name
cis-4-Hydroxy-L-proline, 99%
Packaging
250mg
Price
$162.65
Updated
2024/03/01
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cis-4-Hydroxy-L-proline Chemical Properties,Usage,Production

Chemical Properties

White to beige powder

Uses

cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

Uses

cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line and rat pancreatic carcinoma cell line DSL6A.

Uses

Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.

Definition

ChEBI: L-Proline in which a hydrogen at the 4-position of the pyrrolidine ring is substituted by a hydroxy group (S-configuration).

Biochem/physiol Actions

cis-4-Hydroxy-L-proline (CHP) and its derivatives may have anticancer activity. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

cis-4-Hydroxy-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

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cis-4-Hydroxy-L-proline Suppliers

Wuhan EnTai Technology Development Co,.Ltd
Tel
86-27-82330560
Fax
86-27-82330547
Email
2536851935@qq.com
Country
China
ProdList
348
Advantage
69
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
400-0255188 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5268
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
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View Lastest Price from cis-4-Hydroxy-L-proline manufacturers

Hebei Yibangte Import and Export Co. , Ltd.
Product
cis-4-Hydroxy-L-proline 618-27-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500000kg
Release date
2023-11-24
Henan Aochuang Chemical Co.,Ltd.
Product
cis-4-Hydroxy-L-proline 618-27-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Honest Joy Holdings Limited
Product
(2S,4S)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid 618-27-9
Price
US $0.00/KG
Min. Order
1KG
Purity
97.9%
Supply Ability
100 tons
Release date
2022-02-20

618-27-9, cis-4-Hydroxy-L-prolineRelated Search:


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  • Coclaurine Impurity 4
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  • Specialty Synthesis
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