D-Proline

Product Name: D-Proline
CAS No.: 344-25-2
Chemical Name: D-Proline
Synonyms: Proline;H-D-PRO-OH;D-PRO;D-Pro-OH;(R)-PYRROLIDINE-2-CARBOXYLIC ACID;(2R)-Pyrrolidine-2-carboxylic acid;D-PYRROLIDINE-2-CARBOXYLIC ACID;D-PyrroL;D-PROLINE;D(+)-PROLINE
CBNumber: CB2754303
Molecular Formula: C5H9NO2
Formula Weight: 115.13
MOL File: 344-25-2.mol

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D-Proline Property

Melting point:: 223 °C (dec.) (lit.)
alpha: 84.75 º (c=4, H2O)
Boiling point:: 215.41°C (rough estimate)
Density: 1.36
refractive index: 85 ° (C=4, H2O)
storage temp.: Inert atmosphere,Room Temperature
solubility: Methanol (Slightly), Water (Sparingly)
form: Powder
pka: 1.952(at 25℃)
color: White to yellow to pale brown
optical activity: [α]22/D +85.0°, c = 4 in H2O
Water Solubility: soluble >1000 g/L (20 ºC)
Sensitive: Hygroscopic
BRN: 80811
InChIKey: ONIBWKKTOPOVIA-SCSAIBSYSA-N
LogP: -0.060 (est)
CAS DataBase Reference: 344-25-2(CAS DataBase Reference)
EPA Substance Registry System: D-Proline (344-25-2)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 22-24/25-36/37/39-26
WGK Germany: 3
F: 3-10
Hazard Note: Irritant
TSCA: Yes
HS Code: 29339990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 858919
Product name: D-Proline
Purity: ReagentPlus , ≥99%
Packaging: 500mg
Price: $48.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 858919
Product name: D-Proline
Purity: ReagentPlus , ≥99%
Packaging: 5g
Price: $118
Updated: 2025/07/31

TCI Chemical

Product number: P0994
Product name: D-Proline
Purity: >98.0%(T)
Packaging: 5g
Price: $72
Updated: 2025/07/31

TCI Chemical

Product number: P0994
Product name: D-Proline
Purity: >98.0%(T)
Packaging: 25g
Price: $230
Updated: 2025/07/31

Usbiological

Product number: 237229
Product name: D-Proline 99+%
Packaging: 1g
Price: $153
Updated: 2021/12/16

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D-Proline Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Occurrence

D-proline is an isomer of the naturally occurring amino acid, L-Proline. D-amino acids have been found in relatively high abundance in human plasma and saliva. These amino acids may be of bacterial origin, but there is also evidence that they are endogenously produced through amino acid racemase activity.

Uses

Used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.

Uses

Labelled D-Proline Lasubine II and (+)-Cermizine C.

Uses

proline is a skin-conditioning agent. An amino acid found in the collagen molecule.

Definition

ChEBI: D-proline is the D-enantiomer of proline. It has a role as a mouse metabolite. It is a D-alpha-amino acid and a proline. It is a conjugate base of a D-prolinium. It is a conjugate acid of a D-prolinate. It is an enantiomer of a L-proline. It is a tautomer of a D-proline zwitterion.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 2818, 1949 DOI: 10.1021/ja01176a065
Tetrahedron Letters, 28, p. 6469, 1987 DOI: 10.1016/S0040-4039(00)96890-4

reaction suitability

reaction type: solution phase peptide synthesis

D-Proline Preparation Products And Raw materials

Raw materials

L-Proline

Preparation Products

N-Boc-D-proline (1R,2R)-N-BOC-1-AMINO-2-PHENYLCYCLOPROPANECARBOXYLIC ACID

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D-Proline Suppliers

Americas 1 Austria 1 Belgium 4 Canada 5 China 601 Europe 4 France 3 Germany 13 India 36 Japan 14 Poland 1 Slovakia 1 South Korea 2 Switzerland 9 United Kingdom 21 United States 74 USA 1 Global 791

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Wuxi Bikang Bioengineering Co., Ltd

Tel: 0510-80245888 400-0510-518
Fax: 0510-80245999
Email: 1258079079@qq.com
Country: China
ProdList: 46
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Jinan Dexinjia Bio&Tech Co., Ltd

Tel: 0531-82371986 15269101859
Fax: 0531-82375893
Email: 3276840968@qq.com
Country: China
ProdList: 1604
Advantage: 58

Huaibei Desung Biotech Co., Ltd.

Tel: 0561-2337889 13515618601
Email: 390478052@qq.com
Country: China
ProdList: 1821
Advantage: 58

Hubei Hengluyuan Technology co.ltd

Tel: 027-88188016 18717196322
Email: 1764683941@qq.com
Country: China
ProdList: 6456
Advantage: 58

Hebei Qiaozhou Pharmaceutical Co., Ltd.,

Tel: 13722996852
Email: 13722996852@163.com
Country: China
ProdList: 11
Advantage: 58

Wuhan Roche Technology Development Co., Ltd.,

Tel: 18986168071
Fax: 027-88121016
Email: 18986168071@163.com
Country: China
ProdList: 93
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

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View Lastest Price from D-Proline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: D-Proline 344-25-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98.5%-101%
Supply Ability: 500kg
Release date: 2025-10-21

Hebei Zhuanglai Chemical Trading Co Ltd

Product: D-Proline 344-25-2
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-06

Hebei Chuanghai Biotechnology Co., Ltd

Product: D-Proline 344-25-2
Price: US $0.00-0.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

344-25-2, D-ProlineRelated Search:

D-Tartaric acid D-Alanine D-Proline trans-4-Hydroxy-D-proline N-Benzyloxycarbonyl-D-proline cis-4-Hydroxy-D-proline Fmoc-D-proline BOC-D-PRO-OSU AC-D-PRO-OH (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid Z-D-PYR-OH Methyl pyrrolidine-2-carboxylate hydrochloride D-Pyroglutamic acid Ethyl D-(-)-pyroglutamate Oxaceprol trans-4-Cyclohexyl-L-proline 1-(4-HYDROXY-PHENYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID,1-(4-HYDROXY-PHENYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID H-D-PRO-OTBU

D-Pro-OH

D-Proline≥ 99% (Assay)

D-Proline,99%e.e.

(R)-(+)-PROLINE

(R)-PYRROLIDINE-2-CARBOXYLIC ACID

D-2-PYRROLIDINECARBOXYLIC ACID

D-PYRROLIDINE-2-CARBOXYLIC ACID

D(+)-PROLINE

D-PROLINE

D-PRO

H-D-PYRD(2)-OH

H-D-PRO-OH

D-Proline,99%

H-D-PRO-OH UPS24 (IN BULK QUANTITY)

D-(+)-Prolin

Proline

Glycinate Fumasuan Salt

(2R)-Pyrrolidine-2-carboxylic acid

D-PROLINE, 99+% (98% EE/GLC)

D-PyrroL

idine-2-carboxyL

Captopril Impurity 32

D-(+)-PROLINE ((R)-(+)-PROLINE)

D-PROLINE extrapure

D-Proline-d3

D-Proline, (2R)-2-Carboxypyrrolidine

D-Proline ReagentPlus(R), >=99%

D-Proline Vetec(TM) reagent grade, 98%

D-Proline&gt

D-Proline，98%

D-Proline USP/EP/BP

dextro-(+)-proline

D-Proline CAS No. 344-25-2

D-Proline extrapure CHR, 99%

D-Proline (9CI, ACI)

Captopril Impurity 38

(2R)-pyrrolidin-1-ium-2-carboxylate

(R)-pyrrolidine-2-carboxylic acid, 10 mM in DMSO

<sc>D</sc>-Proline

344-25-2

24344-25-2

145-85-3

344-25-5

344-25-0

C5H9NO2

CARBOXYLIC ACID

Amino Acid Derivatives

Proline

Peptide Synthesis

Specialty Synthesis

Amino Acids and Derivatives

Proline [Pro, P]

Amino Acids and Derivatives

alpha-Amino Acids

Amino Acids

Biochemistry

Amino Acids & Derivatives

Heterocycles