cis-4-Hydroxy-L-proline
- Product Name
- cis-4-Hydroxy-L-proline
- CAS No.
- 618-27-9
- Chemical Name
- cis-4-Hydroxy-L-proline
- Synonyms
- (2S,4S)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;H-CIS-HYP-OH;CIS-4-HYDROXYPROLINE;CIS-HYP-OH;cis-Hydroxy-L-proline;(4S)-4-hydroxypyrrolidine-2-carboxylic acid;CHYP;cis L;cis-L-Hyp-OH;H-L-CIS-HYP-OH
- CBNumber
- CB6158895
- Molecular Formula
- C5H9NO3
- Formula Weight
- 131.13
- MOL File
- 618-27-9.mol
cis-4-Hydroxy-L-proline Property
- Melting point:
- 257 °C (dec.) (lit.)
- alpha
- -59 º (c=2, H2O)
- Boiling point:
- 242.42°C (rough estimate)
- Density
- 1.3121 (rough estimate)
- refractive index
- -59 ° (C=2, H2O)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble
- form
- Powder
- pka
- 2.14±0.40(Predicted)
- color
- White to beige
- Water Solubility
- soluble
- Merck
- 14,4840
- BRN
- 81440
- InChIKey
- PMMYEEVYMWASQN-IMJSIDKUSA-N
- CAS DataBase Reference
- 618-27-9(CAS DataBase Reference)
- EPA Substance Registry System
- L-Proline, 4-hydroxy-, (4S)- (618-27-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-36/37/39-27-26
- WGK Germany
- 3
- F
- 10
- TSCA
- Yes
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H1637
- Product name
- cis-4-Hydroxy-L-proline
- Purity
- collagen synthesis inhibitor
- Packaging
- 50mg
- Price
- $79.9
- Updated
- 2024/03/01
- Product number
- H1637
- Product name
- cis-4-Hydroxy-L-proline
- Purity
- collagen synthesis inhibitor
- Packaging
- 1g
- Price
- $1050
- Updated
- 2024/03/01
- Product number
- H1169
- Product name
- cis-4-Hydroxy-L-proline
- Purity
- >97.0%(T)
- Packaging
- 100mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- H1169
- Product name
- cis-4-Hydroxy-L-proline
- Purity
- >97.0%(T)
- Packaging
- 1g
- Price
- $327
- Updated
- 2024/03/01
- Product number
- H27194
- Product name
- cis-4-Hydroxy-L-proline, 99%
- Packaging
- 250mg
- Price
- $162.65
- Updated
- 2024/03/01
cis-4-Hydroxy-L-proline Chemical Properties,Usage,Production
Chemical Properties
White to beige powder
Uses
cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.
Uses
cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line and rat pancreatic carcinoma cell line DSL6A.
Uses
Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.
Definition
ChEBI: L-Proline in which a hydrogen at the 4-position of the pyrrolidine ring is substituted by a hydroxy group (S-configuration).
Biochem/physiol Actions
cis-4-Hydroxy-L-proline (CHP) and its derivatives may have anticancer activity. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.
cis-4-Hydroxy-L-proline Preparation Products And Raw materials
Raw materials
Preparation Products
cis-4-Hydroxy-L-proline Suppliers
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- 03-36680489
- Fax
- 03-3668-0520
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- Country
- Japan
- ProdList
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View Lastest Price from cis-4-Hydroxy-L-proline manufacturers
- Product
- cis-4-Hydroxy-L-proline 618-27-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2023-11-24
- Product
- cis-4-Hydroxy-L-proline 618-27-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- (2S,4S)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid 618-27-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.9%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20