(4S)-4-hydroxy-L-proline hydrochloride

Product Name: (4S)-4-hydroxy-L-proline hydrochloride
CAS No.: 441067-49-8
Chemical Name: (4S)-4-hydroxy-L-proline hydrochloride
Synonyms: H-cis-Hyp-OH·HCl;(4S)-4-Hydroxy-L-Proline HCl;(4S)-4-hydroxy-L-proline hydrochloride;Cis-4-hydroxy-L-prolineMonohydrochloride;L-Proline, 4-hydroxy-,hydrochloride, cis-;(2s,4S)-4-hydroxy-L-proline hydrochloride;L-Proline, 4-hydroxy-, hydrochloride, (4S)-;(4S)-4-hydroxy-L-Proline hydrochloride (1:1);L-Proline,4-hydroxy-,hydrochloride(1:1),(4S)-;(2S,4S)-cis-4-hydroxy-L-proline hydrochloride
CBNumber: CB22549600
Molecular Formula: C5H10ClNO3
Formula Weight: 167.5908
MOL File: 441067-49-8.mol

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(4S)-4-hydroxy-L-proline hydrochloride Property

storage temp.: Inert atmosphere,Room Temperature
form: Solid
color: White to light yellow
optical activity: -12.74°(C=1.01g/100mI, MEOH, 20°C, 589nm)

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H313May be harmful in contact with skin

H333May be harmful if inhaled

Precautionary statements

P304+P312IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: H952905
Product name: cis-4-Hydroxy-L-prolineHydrochloride
Packaging: 250mg
Price: $55
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0009623
Product name: CIS-4-HYDROXY-L-PROLINE HYDROCHLORIDE
Purity: 98.00%
Packaging: 5MG
Price: $504.19
Updated: 2021/12/16

Matrix Scientific

Product number: 057306
Product name: (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acidhydrochloride
Purity: 95%
Packaging: 1g
Price: $14
Updated: 2021/12/16

Matrix Scientific

Product number: 057306
Product name: (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acidhydrochloride
Purity: 95%
Packaging: 5g
Price: $42
Updated: 2021/12/16

Matrix Scientific

Product number: 057306
Product name: (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acidhydrochloride
Purity: 95%
Packaging: 25g
Price: $127
Updated: 2021/12/16

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(4S)-4-hydroxy-L-proline hydrochloride Chemical Properties,Usage,Production

Uses

cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

IC 50

Non-cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

(4S)-4-hydroxy-L-proline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(4S)-4-hydroxy-L-proline hydrochloride Suppliers

China 75 India 3 United Kingdom 1 United States 8 Global 87

Meryer (Shanghai) Chemical Technology Co., Ltd.

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Pure Chemistry Scientific Inc.

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ZhengZhou HuaWen Chemical Co.Ltd

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Chengdu Pukang Biotechnology Co., Ltd

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View Lastest Price from (4S)-4-hydroxy-L-proline hydrochloride manufacturers

Career Henan Chemical Co

Product: 4S)-4-hydroxy-L-proline hydrochloride 441067-49-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-20

441067-49-8, (4S)-4-hydroxy-L-proline hydrochlorideRelated Search:

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(4S)-4-hydroxy-L-proline hydrochloride

L-Proline, 4-hydroxy-,hydrochloride, cis-

L-Proline,4-hydroxy-,hydrochloride(1:1),(4S)-

H-cis-Hyp-OH·HCl

cis-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride

L-Proline, 4-hydroxy-, hydrochloride, (4S)-

(2s,4S)-4-hydroxy-L-proline hydrochloride

Cis-4-hydroxy-L-prolineMonohydrochloride

(2S,4S)-cis-4-hydroxy-L-proline hydrochloride

(4S)-4-hydroxy-L-proline hydrochloride USP/EP/BP

(4S)-4-Hydroxy-L-Proline HCl

(4S)-4-hydroxy-L-Proline hydrochloride (1:1)

(2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride , H-cis-Hyp-OH·HCl

(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid Hydrochloride/cis-4-Hydroxy-L-proline hydrochloride

(2S,4S)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE 98%

441067-49-8