ChemicalBook > CAS DataBase List > (4S)-4-hydroxy-L-proline hydrochloride

(4S)-4-hydroxy-L-proline hydrochloride

Product Name
(4S)-4-hydroxy-L-proline hydrochloride
CAS No.
441067-49-8
Chemical Name
(4S)-4-hydroxy-L-proline hydrochloride
Synonyms
H-cis-Hyp-OH·HCl;(4S)-4-Hydroxy-L-Proline HCl;(4S)-4-hydroxy-L-proline hydrochloride;Cis-4-hydroxy-L-prolineMonohydrochloride;L-Proline, 4-hydroxy-,hydrochloride, cis-;(2s,4S)-4-hydroxy-L-proline hydrochloride;L-Proline, 4-hydroxy-, hydrochloride, (4S)-;(4S)-4-hydroxy-L-Proline hydrochloride (1:1);L-Proline,4-hydroxy-,hydrochloride(1:1),(4S)-;(2S,4S)-cis-4-hydroxy-L-proline hydrochloride
CBNumber
CB22549600
Molecular Formula
C5H10ClNO3
Formula Weight
167.5908
MOL File
441067-49-8.mol
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(4S)-4-hydroxy-L-proline hydrochloride Property

storage temp. 
Inert atmosphere,Room Temperature
form 
Solid
color 
White to light yellow
optical activity
-12.74°(C=1.01g/100mI, MEOH, 20°C, 589nm)
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Safety

HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H313May be harmful in contact with skin

H333May be harmful if inhaled

Precautionary statements

P304+P312IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
H952905
Product name
cis-4-Hydroxy-L-prolineHydrochloride
Packaging
250mg
Price
$55
Updated
2021/12/16
Matrix Scientific
Product number
057306
Product name
(2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acidhydrochloride
Purity
95%
Packaging
1g
Price
$14
Updated
2021/12/16
Matrix Scientific
Product number
057306
Product name
(2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acidhydrochloride
Purity
95%
Packaging
5g
Price
$42
Updated
2021/12/16
Matrix Scientific
Product number
057306
Product name
(2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acidhydrochloride
Purity
95%
Packaging
25g
Price
$127
Updated
2021/12/16
AK Scientific
Product number
J94972
Product name
cis-4-Hydroxy-L-prolinehydrochloride
Packaging
25g
Price
$130
Updated
2021/12/16
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(4S)-4-hydroxy-L-proline hydrochloride Chemical Properties,Usage,Production

Uses

cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

IC 50

Non-cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

(4S)-4-hydroxy-L-proline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (4S)-4-hydroxy-L-proline hydrochloride manufacturers

Career Henan Chemical Co
Product
4S)-4-hydroxy-L-proline hydrochloride 441067-49-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-20

441067-49-8, (4S)-4-hydroxy-L-proline hydrochlorideRelated Search:

L-Phenylalanine Methyl cis-4-Aminocyclohexanecarboxylate Hydrochloride Cis-4-Aminoadamantan-1-ol hydrochloride cis-4-Aminocyclohexanecarboxylic acid 4α-Aminocyclohexan-1α-ol CIS-4-CYCLOHEXENE-1,2-DICARBOXYLIC ACID CIS-4-METHYL-CYCLOHEXYLAMINE HCL 4-aminocyclohexan-1-ol cis-4-Hydroxy-D-proline L-Lysine L-Cysteine cis-4-Hydroxy-L-proline cis-4-Hydroxy-D-proline hydrochloride

  • (4S)-4-hydroxy-L-proline hydrochloride
  • L-Proline, 4-hydroxy-,hydrochloride, cis-
  • L-Proline,4-hydroxy-,hydrochloride(1:1),(4S)-
  • H-cis-Hyp-OH·HCl
  • cis-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
  • L-Proline, 4-hydroxy-, hydrochloride, (4S)-
  • (2s,4S)-4-hydroxy-L-proline hydrochloride
  • Cis-4-hydroxy-L-prolineMonohydrochloride
  • (2S,4S)-cis-4-hydroxy-L-proline hydrochloride
  • (4S)-4-hydroxy-L-proline hydrochloride USP/EP/BP
  • (4S)-4-Hydroxy-L-Proline HCl
  • (4S)-4-hydroxy-L-Proline hydrochloride (1:1)
  • (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride , H-cis-Hyp-OH·HCl
  • (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid Hydrochloride/cis-4-Hydroxy-L-proline hydrochloride
  • (2S,4S)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE 98%
  • 441067-49-8