cis-4-Aminocyclohexanecarboxylic acid
- Product Name
- cis-4-Aminocyclohexanecarboxylic acid
- CAS No.
- 3685-23-2
- Chemical Name
- cis-4-Aminocyclohexanecarboxylic acid
- Synonyms
- H-CIS-NH(4)CHEX-OH;cis-4-AMinocyclohexanecar...;CIS-4-AMINOHEXAHYDROBENZOIC ACID;CIS-4-AMINOCYCLOHEXANECARBOXYLIC ACI;AminocyclohexanecarboxylicAcid,cis-4-;4-AMINO CYCLOHEXANE-L-CARBOXYLIC ACID;Ethyl-3(pyridine-2ylamino) propionate;CIS-4-AMINOCYCLOHEXANECARBOXYLIC ACID;cis-4-Aminocyclohexyl carboxylic acid;CIS-4-AMINOCYCLOHEXHANECARBOXYLIC ACID
- CBNumber
- CB7154506
- Molecular Formula
- C7H13NO2
- Formula Weight
- 143.18
- MOL File
- 3685-23-2.mol
cis-4-Aminocyclohexanecarboxylic acid Property
- Melting point:
- 299-301 °C(lit.)
- Boiling point:
- 280.0±33.0 °C(Predicted)
- Density
- 9 g/cm3
- storage temp.
- Inert atmosphere,Room Temperature
- Water Solubility
- Soluble in water
- solubility
- Methanol (Very Slightly), Water (Sparingly)
- form
- Powder
- pka
- 4.62±0.25(Predicted)
- color
- Off-white
- InChI
- InChI=1S/C7H13NO2/c8-6-3-1-5(2-4-6)7(9)10/h5-6H,1-4,8H2,(H,9,10)/t5-,6+
- InChIKey
- DRNGLYHKYPNTEA-OLQVQODUSA-N
- SMILES
- [C@@H]1(C(O)=O)CC[C@H](N)CC1
- CAS DataBase Reference
- 3685-23-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A1448
- Product name
- cis-4-Aminocyclohexanecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- A1448
- Product name
- cis-4-Aminocyclohexanecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $66
- Updated
- 2025/07/31
- Product number
- A1448
- Product name
- cis-4-Aminocyclohexanecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $196
- Updated
- 2025/07/31
- Product number
- C497405
- Product name
- cis-4-Aminocyclohexanecarboxylic Acid
- Packaging
- 10g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- FA11366
- Product name
- cis-4-Aminocyclohexane carboxylic acid
- Packaging
- 5G
- Price
- $40
- Updated
- 2021/12/16
cis-4-Aminocyclohexanecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
off-white powder
Uses
cis-4-Aminocyclohexanecarboxylic Acid is used as a reagent in the synthesis of thiazolylquinazolines
Synthesis
150-13-0
1776-53-0
3685-23-2
The general procedure for the synthesis of 4-aminocyclohexanecarboxylic acid and cis-4-aminocyclohexanecarboxylic acid from p-aminobenzoic acid is as follows: p-aminobenzoic acid (10.0 g, 0.07 mol, 1 eq.), 5% Ru/C catalyst (2.50 g), and 10% NaOH solution (100.0 mL) were added in an autoclave. The mixture was stirred to react under 100 bar hydrogen pressure and 15 bar hydrogen atmosphere. After 20 hours of reaction, the progress of the reaction was detected by thin layer chromatography (TLC), the unfolding agent was dichloromethane/methanol/ammonia (5:5:1, v/v/v), and the staining agent was ninhydrin to confirm that the starting material was completely consumed. Nuclear magnetic resonance (NMR) analysis showed that the reaction was fully converted and the ratio of cis to trans product was 1:4.6. After confirming that the reaction was complete, the reaction was stopped.
References
[1] European Journal of Medicinal Chemistry, 2001, vol. 36, # 3, p. 265 - 286
[2] Biochemische Zeitschrift, 1933, vol. 262, p. 462
[3] Journal of the American Chemical Society, 1938, vol. 60, p. 2341,2343
[4] Chemische Berichte, 1942, vol. 75, p. 425,428
[5] Chemische Berichte, 1943, vol. 76, p. 1019,1023
cis-4-Aminocyclohexanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from cis-4-Aminocyclohexanecarboxylic acid manufacturers
- Product
- cis-4-Aminocyclohexanecarboxylic acid 3685-23-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-06
- Product
- Manufacturers wholesale Cis-4-Amino Cyclohexane Carboxylic Acid CAS NO.3685-23-2 CAS NO.3685-23-2 3685-23-2
- Price
- US $1.00/G
- Min. Order
- 100G
- Purity
- 99.9%
- Supply Ability
- 50000 tons
- Release date
- 2018-10-24
- Product
- cis-4-Aminocyclohexanecarboxylic Acid 3685-23-2
- Price
- US $2.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 30tons
- Release date
- 2020-09-04