cis-4-Hydroxycyclohexanecarboxylic acid

Product Name: cis-4-Hydroxycyclohexanecarboxylic acid
CAS No.: 3685-22-1
Chemical Name: cis-4-Hydroxycyclohexanecarboxylic acid
Synonyms: CIS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;CIS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;RANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;cis-4-HydroxycyclohexanecarboxylicAcid>cis-4-Hydroxycyclohexane-1-carboxylic acid;(1s,4s)-4-hydroxycyclohexanecarboxylic acid;Cyclohexanecarboxylic acid, 4-hydroxy-, cis-;(1s,4s)-4-hydroxycyclohexane-1-carboxylic acid;cis-4-Hydroxycyclohexanecarboxylic Acid
CBNumber: CB0727376
Molecular Formula: C7H12O3
Formula Weight: 144.17
MOL File: 3685-22-1.mol

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cis-4-Hydroxycyclohexanecarboxylic acid Property

Melting point:: 150°C
Boiling point:: 115 °C(Press: 8 Torr)
Density: 1.246
storage temp.: 2-8°C
solubility: almost transparency in Methanol
form: powder to crystal
pka: pK1:4.836 (25°C)
color: White to Almost white
InChI: InChI=1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)/t5-,6+
InChIKey: HCFRWBBJISAZNK-OLQVQODUSA-N
SMILES: [C@@H]1(C(O)=O)CC[C@H](O)CC1
CAS DataBase Reference: 3685-22-1

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Safety

Hazard Codes: T
Risk Statements: 36/37/38-25
Safety Statements: 26-36/37/39-45
RIDADR: UN 2811 6.1 / PGIII
HS Code: 2918199890

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ANV00233
Product name: cis-4-Hydroxycyclohexanecarboxylic acid
Purity: AldrichCPR
Packaging: 1g
Price: $174
Updated: 2024/03/01

TCI Chemical

Product number: H0980
Product name: cis-4-Hydroxycyclohexanecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $141
Updated: 2024/03/01

TCI Chemical

Product number: H0980
Product name: cis-4-Hydroxycyclohexanecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $436
Updated: 2024/03/01

TRC

Product number: R729038
Product name: trans-4-Hydroxycyclohexanecarboxylic Acid
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 123388
Product name: cis-4-Hydroxycyclohexanecarboxylic acid
Purity: 97.0%
Packaging: 1g
Price: $116
Updated: 2021/12/16

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cis-4-Hydroxycyclohexanecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to Almost white powder to crystal. Melting point: 148.0 to 152.0 °C.

Uses

Cis-4-Hydroxycyclohexanecarboxylic acid is a metabolite of p-hydroxybenzoic acid. It is the major metabolite in the urine of rats treated with exogenous p-hydroxybenzoic acid. It has been found to have immunosuppressive activities in rat hepatocytes, as well as metabolic disorders that are related to hyperglycemia or diabetes mellitus.

Definition

ChEBI: 4-Hydroxycyclohexylcarboxylic acid is a hydroxy monocarboxylic acid.

Synthesis

cis-4-Hydroxycyclohexanecarboxylic acid can be synthesized through the following steps:
1. In an argon glove box, dissolve ligands L1-(S,R)-f-ambinol (7.5mg, 0.0105mmol) and [Ir(COD)Cl]2 (3.4mg, 0.005mmol) in 1 mL of iPrOH in a 2mL vial and stir at room temperature for 2 h.
2. Put 1 mmol of raw material 4-substituted cyclohexanone into a 4 mL hydrogenation flask.
3. Add 0.1 mL of the in-situ complexed catalyst solution and 1.6 mg of tBuOLi solid powder to the hydrogenation flask.
4. Add 1 mL of EtOH to dissolve the reactants in the hydrogenation flask.
5. Put the reaction flask into the hydrogenation kettle and replace the kettle body with hydrogen three times.
6. Fill the kettle with 5bar H2 and react at room temperature for 12h.
7. After the reaction is completed, carefully release the hydrogen and spin-dry the solvent under reduced pressure.
8. Purify the hydrogenated product cis-4-substituted cyclohexanol by silica gel column.
9. Obtain the final product cis-4-Hydroxycyclohexanecarboxylic acid.

cis-4-Hydroxycyclohexanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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cis-4-Hydroxycyclohexanecarboxylic acid Suppliers

Americas 1 China 94 Europe 1 Germany 2 India 4 Japan 1 United Kingdom 1 United States 7 Global 111

CHIRIAL CO.LTD

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View Lastest Price from cis-4-Hydroxycyclohexanecarboxylic acid manufacturers

ChiRial Biomaterial Co Ltd

Product: cis-4-hydroxycyclohexanecarboxylic acid 3685-22-1
Price: US $0.00-0.00/mg
Min. Order: 100mg
Purity: 98%
Supply Ability: 10 tons
Release date: 2023-03-17

Henan Aochuang Chemical Co.,Ltd.

Product: TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID 3685-22-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Career Henan Chemical Co

Product: TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID 3685-22-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

3685-22-1, cis-4-Hydroxycyclohexanecarboxylic acidRelated Search:

CIS-4-CYCLOHEXENE-1,2-DICARBOXYLIC ACID H-CIS-HYP-OME HCL cis-4-Hydroxy-D-proline cis-4-Hydroxy-L-proline Cyclohexanecarboxylic acid, 4-hydroxy-, Methyl ester, cis- CIS-3-AMINOCYCLOHEXANECARBOXYLICACID Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester Tetrahydro-5-oxo-2- furancarboxyli 4-Hydroxycyclohexanecarboxylic acid ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE 1-AMINO-4-OXOCYCLOHEXANECARBOXYLIC ACID ETHYLENE KETAL METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE 4-METHOXYCYCLOHEXANECARBOXYLIC ACID cis-4-Hydroxycyclohexanecarboxylic acid PICROTIN ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID 8-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-1,4-DIOXA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID

TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID

CIS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID

(1s,4s)-4-hydroxycyclohexanecarboxylic acid

RANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID

<i>cis</i>-4-Hydroxycyclohexanecarboxylic Acid

Cyclohexanecarboxylic acid, 4-hydroxy-, cis-

cis-4-Hydroxycyclohexane-1-carboxylic acid

cis-4-HydroxycyclohexanecarboxylicAcid&gt

(1s,4s)-4-hydroxycyclohexane-1-carboxylic acid

CIS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID

3685-22-1

4-Substituted Cyclohexanecarboxylic Acids

Chalcones, etc. (Building Blocks for Liquid Crystals)

Building Blocks for Liquid Crystals

4-Substituted Cyclohexanecarboxylic Acids