cis-4-Hydroxycyclohexanecarboxylic acid
- Product Name
- cis-4-Hydroxycyclohexanecarboxylic acid
- CAS No.
- 3685-22-1
- Chemical Name
- cis-4-Hydroxycyclohexanecarboxylic acid
- Synonyms
- CIS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;CIS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;RANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;cis-4-HydroxycyclohexanecarboxylicAcid>cis-4-Hydroxycyclohexane-1-carboxylic acid;(1s,4s)-4-hydroxycyclohexanecarboxylic acid;Cyclohexanecarboxylic acid, 4-hydroxy-, cis-;(1s,4s)-4-hydroxycyclohexane-1-carboxylic acid;cis-4-Hydroxycyclohexanecarboxylic Acid
- CBNumber
- CB0727376
- Molecular Formula
- C7H12O3
- Formula Weight
- 144.17
- MOL File
- 3685-22-1.mol
cis-4-Hydroxycyclohexanecarboxylic acid Property
- Melting point:
- 150°C
- Boiling point:
- 115 °C(Press: 8 Torr)
- Density
- 1.246
- storage temp.
- 2-8°C
- solubility
- almost transparency in Methanol
- form
- powder to crystal
- pka
- pK1:4.836 (25°C)
- color
- White to Almost white
- InChI
- InChI=1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)/t5-,6+
- InChIKey
- HCFRWBBJISAZNK-OLQVQODUSA-N
- SMILES
- [C@@H]1(C(O)=O)CC[C@H](O)CC1
- CAS DataBase Reference
- 3685-22-1
Safety
- Hazard Codes
- T
- Risk Statements
- 36/37/38-25
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2811 6.1 / PGIII
- HS Code
- 2918199890
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- ANV00233
- Product name
- cis-4-Hydroxycyclohexanecarboxylic acid
- Purity
- AldrichCPR
- Packaging
- 1g
- Price
- $174
- Updated
- 2024/03/01
- Product number
- H0980
- Product name
- cis-4-Hydroxycyclohexanecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $141
- Updated
- 2024/03/01
- Product number
- H0980
- Product name
- cis-4-Hydroxycyclohexanecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $436
- Updated
- 2024/03/01
- Product number
- R729038
- Product name
- trans-4-Hydroxycyclohexanecarboxylic Acid
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 123388
- Product name
- cis-4-Hydroxycyclohexanecarboxylic acid
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $116
- Updated
- 2021/12/16
cis-4-Hydroxycyclohexanecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White to Almost white powder to crystal. Melting point: 148.0 to 152.0 °C.
Uses
Cis-4-Hydroxycyclohexanecarboxylic acid is a metabolite of p-hydroxybenzoic acid. It is the major metabolite in the urine of rats treated with exogenous p-hydroxybenzoic acid. It has been found to have immunosuppressive activities in rat hepatocytes, as well as metabolic disorders that are related to hyperglycemia or diabetes mellitus.
Definition
ChEBI: 4-Hydroxycyclohexylcarboxylic acid is a hydroxy monocarboxylic acid.
Synthesis
cis-4-Hydroxycyclohexanecarboxylic acid can be synthesized through the following steps:
1. In an argon glove box, dissolve ligands L1-(S,R)-f-ambinol (7.5mg, 0.0105mmol) and [Ir(COD)Cl]2 (3.4mg, 0.005mmol) in 1 mL of iPrOH in a 2mL vial and stir at room temperature for 2 h.
2. Put 1 mmol of raw material 4-substituted cyclohexanone into a 4 mL hydrogenation flask.
3. Add 0.1 mL of the in-situ complexed catalyst solution and 1.6 mg of tBuOLi solid powder to the hydrogenation flask.
4. Add 1 mL of EtOH to dissolve the reactants in the hydrogenation flask.
5. Put the reaction flask into the hydrogenation kettle and replace the kettle body with hydrogen three times.
6. Fill the kettle with 5bar H2 and react at room temperature for 12h.
7. After the reaction is completed, carefully release the hydrogen and spin-dry the solvent under reduced pressure.
8. Purify the hydrogenated product cis-4-substituted cyclohexanol by silica gel column.
9. Obtain the final product cis-4-Hydroxycyclohexanecarboxylic acid.
cis-4-Hydroxycyclohexanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
cis-4-Hydroxycyclohexanecarboxylic acid Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23680
- Advantage
- 75
View Lastest Price from cis-4-Hydroxycyclohexanecarboxylic acid manufacturers
- Product
- cis-4-hydroxycyclohexanecarboxylic acid 3685-22-1
- Price
- US $0.00-0.00/mg
- Min. Order
- 100mg
- Purity
- 98%
- Supply Ability
- 10 tons
- Release date
- 2023-03-17
- Product
- TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID 3685-22-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID 3685-22-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26