TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID
- Product Name
- TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID
- CAS No.
- 3685-26-5
- Chemical Name
- TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID
- Synonyms
- NSC7857;NSC 7857;NSC-7857;Hydroxycyclohexanecarboxylicacid;trans-1-Carboxy-4-hydroxycyclohexane;trans-4-Hydroxycyclohexylcarboxylic acid;TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;trans-4-HydroxycyclohexanecarboxylicAcid>(1r,4r)-4-hydroxycyclohexanecarboxylic acid;trans-4-Hydroxycyclohexane-1-carboxylic acid
- CBNumber
- CB3727377
- Molecular Formula
- C7H12O3
- Formula Weight
- 144.17
- MOL File
- 3685-26-5.mol
TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID Property
- Melting point:
- 145°C
- Boiling point:
- 308℃
- Density
- 1.246
- Flash point:
- 154℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO, Methanol
- pka
- pK1:4.687 (25°C)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)/t5-,6-
- InChIKey
- HCFRWBBJISAZNK-IZLXSQMJSA-N
- SMILES
- [C@@H]1(C(O)=O)CC[C@@H](O)CC1
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2916200090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- H1175
- Product name
- trans-4-Hydroxycyclohexanecarboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- H1175
- Product name
- trans-4-Hydroxycyclohexanecarboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $205
- Updated
- 2025/07/31
- Product number
- H826900
- Product name
- trans-4-HydroxycyclohexylcarboxylicAcid
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- J53544
- Product name
- trans-4-Hydroxycyclohexanecarboxylic Acid
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- CS-M0763
- Product name
- trans-4-Hydroxycyclohexanecarboxylic Acid
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $33
- Updated
- 2021/12/16
TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
trans-4-Hydroxycyclohexylcarboxylic Acid acts as a reagent in the synthetic preparation of pyrazole-pyrimidine preparation as TTK inhibitors and potential antitumors, Preparation and Janus kinase 1 (JAK1)-selective inhibitory activity of benzimidazole derivatives.
Definition
ChEBI: 4-Hydroxycyclohexylcarboxylic acid is a hydroxy monocarboxylic acid.
Synthesis
3618-03-9
3685-22-1
General procedure for the synthesis of cis-4-hydroxycyclohexanecarboxylic acid from methyl cis-4-hydroxycyclohexanecarboxylate: 20 g of methyl cis-4-hydroxycyclohexanecarboxylate was dissolved in 80 mL of methanol and cooled in an ice-water bath. Slowly 40mL of 5 mol/L sodium hydroxide solution was added dropwise, and after completion of the dropwise addition, the reaction mixture was stirred at room temperature overnight. After the reaction was completed, 150 mL of water was added to dilute it. The mixture was extracted twice with ethyl acetate and the organic phase was discarded. The aqueous phase was adjusted to pH 3 with 1 mol/L HCl and extracted twice with 50 mL of ethyl acetate to combine the organic phases. The organic phase was washed twice with saturated saline in turn, dried and decolorized. After filtration, ethyl acetate was recovered by distillation under reduced pressure to give 16 g of white solid product cis-4-hydroxycyclohexanecarboxylic acid in 90% yield.
References
[1] Patent: CN105061424, 2016, B. Location in patent: Paragraph 0029; 0031
TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID Suppliers
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View Lastest Price from TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID manufacturers
- Product
- trans-4-Hydroxycyclohexanecarboxylic acid 3685-26-5
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-24
- Product
- TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID 3685-26-5
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-19
- Product
- Hydroxycyclohexanecarboxylicacid 3685-26-5
- Price
- US $0.00-0.00/g
- Min. Order
- 100g
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-08-10