trans-Methyl4-hydroxycyclohexanecarboxylate

Product Name: trans-Methyl4-hydroxycyclohexanecarboxylate
CAS No.: 6125-57-1
Chemical Name: trans-Methyl4-hydroxycyclohexanecarboxylate
Synonyms: Methyl trans-4-hydroxycyclohexane formate;trans-Methyl4-hydroxycyclohexanecarboxylate;Methyl rans-4-Hydroxycyclohexanecarboxylate;Methyl trans-4-Hydroxycyclohexanecarboxylate;Methyltrans-4-Hydroxycyclohexanecarboxylate>Methyl trans-4-hydroxycyclohexane-1-carboxylate;Methyl (1s,4s)-4-hydroxycyclohexane-1-carboxylate;Methyl trans-4-Hydroxycyclohexanecarboxylate;trans-4-Hydroxycyclohexanecarboxylic Acid Methyl Ester;Trans-Methyl 4-Hydroxycyclohexanecarboxylate(WXC01475)
CBNumber: CB11235206
Molecular Formula: C8H14O3
Formula Weight: 158.2
MOL File: 6125-57-1.mol

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trans-Methyl4-hydroxycyclohexanecarboxylate Property

Boiling point:: 125°C/0.3mmHg(lit.)
Density: 1.103
refractive index: 1.4693 (589.3 nm 23℃)
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
pka: 14.96±0.40(Predicted)
color: Colorless to Almost colorless
InChI: InChI=1S/C8H14O3/c1-11-8(10)6-2-4-7(9)5-3-6/h6-7,9H,2-5H2,1H3/t6-,7-
InChIKey: HYDYVXROZHFTGB-LJGSYFOKSA-N
SMILES: [C@@H]1(C(OC)=O)CC[C@@H](O)CC1
CAS DataBase Reference: 6125-57-1

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Safety

HS Code: 2918199890

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M1991
Product name: Methyl trans-4-Hydroxycyclohexanecarboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: M1991
Product name: Methyl trans-4-Hydroxycyclohexanecarboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $214
Updated: 2025/07/31

TRC

Product number: M323865
Product name: Methylrans-4-Hydroxycyclohexanecarboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 8254AL
Product name: Methyl trans-4-Hydroxycyclohexanecarboxylate
Packaging: 1g
Price: $91
Updated: 2021/12/16

AK Scientific

Product number: 8254AL
Product name: Methyl trans-4-Hydroxycyclohexanecarboxylate
Packaging: 5g
Price: $157
Updated: 2021/12/16

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trans-Methyl4-hydroxycyclohexanecarboxylate Chemical Properties,Usage,Production

Synthesis

99-76-3

3618-03-9

Example 1: To a Parr autoclave reactor was added 150 mL of methanol followed by 25 g of methyl 4-hydroxybenzoate (nipagin methyl ester). After displacing the air in the reactor with nitrogen, 2.5 g of 5% rhodium/alumina catalyst was added. The reaction mixture was pressurized to 3.74 MPa under hydrogen atmosphere and reacted for 18 hours under continuous shaking. Upon completion of the reaction, the hydrogen was again replaced with nitrogen and the reaction mixture was filtered through a diatomaceous earth pad to separate the catalyst. The diatomaceous earth pad was washed with methanol, taking care to avoid drying the catalyst. All filtrates were combined and methanol was removed by distillation under reduced pressure at about 40 °C. The residue was dissolved in 200 mL of ether and 3 g of anhydrous potassium carbonate was added. The precipitated alumina and potassium carbonate were removed by diatomaceous earth filtration and washed with ether. After combining the filtrates, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by a Kugelrohr short-range distillation apparatus at 80-100 °C/1 mmHg to give 25.0 g (98% yield) of the colorless oily liquid methyl 4-hydroxycyclohexanecarboxylate. The product was characterized by 1H NMR (CDCl3, 60 MHz): δ 3.85 (s, 1H), 3.65 (s, 3H), 2.50-1.20 (m, 10H).

References

[1] Canadian Journal of Chemistry, 1982, vol. 60, p. 1996 - 2001
[2] Journal of Organic Chemistry, 1991, vol. 56, # 5, p. 1758 - 1763
[3] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 23, p. 6309 - 6323
[4] Bulletin de la Societe Chimique de France, 1970, p. 556 - 562
[5] Bulletin de la Societe Chimique de France, 1969, p. 781 - 787

trans-Methyl4-hydroxycyclohexanecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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trans-Methyl4-hydroxycyclohexanecarboxylate Suppliers

Americas 1 China 84 Europe 1 India 3 Japan 1 Switzerland 1 United Kingdom 1 United States 7 Global 99

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View Lastest Price from trans-Methyl4-hydroxycyclohexanecarboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Methyl 4-hydroxycyclohexanecarboxylate 6125-57-1
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-24

Pharmahands (Taizhou) Co., Ltd.

Product: trans-Methyl4-hydroxycyclohexanecarboxylate 6125-57-1
Price: US $0.00-0.00/Kg/Bag
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg/month
Release date: 2020-10-30

Career Henan Chemical Co

Product: trans-Methyl4-hydroxycyclohexanecarboxylate 6125-57-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 755
Release date: 2019-09-01

6125-57-1, trans-Methyl4-hydroxycyclohexanecarboxylateRelated Search:

4-METHOXY-3-BUTEN-2-ONE trans-4-Methycyclohexyl isocyanate p-Coumaric acid TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID trans-4-Methylcyclohexyl amine trans-4-MethoxycyclohexanaMine HCl trans-4-Methylcyclohexylamine hydrochloride METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE

trans-Methyl4-hydroxycyclohexanecarboxylate

Methyl trans-4-Hydroxycyclohexanecarboxylate

trans-4-Hydroxycyclohexanecarboxylic Acid Methyl Ester

trans-4-Hydroxycyclohexane-1-carboxylic acid methyl ester

Methyl <i>trans</i>-4-Hydroxycyclohexanecarboxylate

trans-4-hydroxy-cyclohexane-carboxylic acid-(1)-methyl ester

Trans-Methyl 4-Hydroxycyclohexanecarboxylate(WXC01475)

Methyl trans-4-hydroxycyclohexane-1-carboxylate

Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester,trans-

Methyl trans-4-hydroxycyclohexane formate

Methyltrans-4-Hydroxycyclohexanecarboxylate&gt

Methyl rans-4-Hydroxycyclohexanecarboxylate

Methyl (1s,4s)-4-hydroxycyclohexane-1-carboxylate

6125-57-1