p-Coumaric acid
- Product Name
- p-Coumaric acid
- CAS No.
- 501-98-4
- Chemical Name
- p-Coumaric acid
- Synonyms
- TRANS-4-HYDROXYCINNAMIC ACID;trans-p-Hydroxycinnamic acid;(E)-3-(4-hydroxyphenyl)acrylic acid;p-CouMaric;TRANS-4-COUMARIC ACID;TRANS-P-COUMARIC ACID;(E)-p-Coumaric acid;PHCA;Naringeninic acid;(e)-p-coumaricacid
- CBNumber
- CB6164395
- Molecular Formula
- C9H8O3
- Formula Weight
- 164.16
- MOL File
- 501-98-4.mol
p-Coumaric acid Property
- Melting point:
- 214 °C (dec.)(lit.)
- Boiling point:
- 231.61°C (rough estimate)
- Density
- 1.1403 (rough estimate)
- refractive index
- 1.4500 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- ethanol: soluble50mg/mL
- form
- Powder
- pka
- 4.65±0.10(Predicted)
- color
- Off-white to beige or greenish
- Odor
- at 100.00?%. balsamic
- Water Solubility
- soluble
- Merck
- 14,2560
- BRN
- 2207383
- Stability:
- Light Sensitive
- InChIKey
- NGSWKAQJJWESNS-ZZXKWVIFSA-N
- LogP
- 1.460
- CAS DataBase Reference
- 501-98-4(CAS DataBase Reference)
- NIST Chemistry Reference
- p-Hydroxycinnamic acid(501-98-4)
- EPA Substance Registry System
- 2-Propenoic acid, 3-(4-hydroxyphenyl)-, (2E)- (501-98-4)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 2
- RTECS
- GD9095000
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C9008
- Product name
- p-Coumaric acid
- Purity
- ≥98.0% (HPLC)
- Packaging
- 1g
- Price
- $15.7
- Updated
- 2024/03/01
- Product number
- 03200595
- Product name
- p-Coumaric acid
- Purity
- primary pharmaceutical reference standard
- Packaging
- 50mg
- Price
- $405
- Updated
- 2024/03/01
- Product number
- 55823
- Product name
- trans-p-Coumaric acid
- Purity
- analytical standard
- Packaging
- 50MG
- Price
- $78
- Updated
- 2022/05/15
- Product number
- C0393
- Product name
- trans-p-Coumaric Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $56
- Updated
- 2024/03/01
- Product number
- C0393
- Product name
- trans-p-Coumaric Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 100g
- Price
- $144
- Updated
- 2024/03/01
p-Coumaric acid Chemical Properties,Usage,Production
Chemical Properties
Off-white to beige or greenish powder. Soluble in alcohol, ether and hot water, slightly soluble in benzene, insoluble in petroleum ether.
Uses
trans-p-Coumaric Acid is the E-isomer of p-Coumaric Acid (C755365), a hydroxy derivative of Cinnamic Acid with antioxidant properties. p-Coumaric acid is a is a major component of lignocellulose. Stud ies suggest that p-Coumaric Acid may reduce the risk of cancer by reducing the formation of carcinogenic nitrosamines.
Definition
ChEBI: p-coumaric acid is the trans-isomer of 4-coumaric acid. 4-coumaric acid is a coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring. It has a role as a plant metabolite. It is a conjugate acid of a 4-coumarate.
Application
trans-4-Hydroxycinnamic acid is used as a hydroxycinnamic acid with antioxidant properties. p-Coumaric acid is an aromatic phytochemical for proteomics research. It has been used as a component of chemiluminescent substrate for protein detection in western blotting.
Preparation
Synthesis of p-Coumaric acid: take o-acetylsalicyloyl chloride as raw material, in the presence of magnesium chloride, react with diethyl malonate in acetonitrile solvent, then add triethylamine, and react at 0°C for 1 h to obtain ( 2-acetoxybenzoyl) diethyl malonate product, then heated to 50°C in potassium hydroxide/methanol solution, reacted for 3h, and cyclized to obtain p-Coumaric acid.
Biochem/physiol Actions
p-Coumaric acid is mainly a plant metabolite which exhibits antioxidant and anti-inflammatory properties. It also shows bactericidal activity by damaging bacterial cell membrane and by interacting with bacterial DNA. In western blot, p-coumaric is also used as an enhancer in chemiluminescent substrate.
Hydroxycinnamic acid found in many fruits and vegetables.
Purification Methods
Crystallise p-coumaric acid from H2O (charcoal). It forms needles from concentrated aqueous solutions as the anhydrous acid, but from hot dilute solutions the monohydrate acid separates on slow cooling. The acid (33g) has been crystallised from 2.5L of H2O (1.5g charcoal) yielding 28.4g of recrystallised acid, m 207o. It is insoluble in *C6H6 or pet ether. The UV in 95% EtOH has max 223 and 286nm ( 14,450 and 19000 M-1cm-1). [UV Wheeler & Covarrubias J Org Chem 28 2015 1963, Corti Helv Chim Acta 32 681 1949, Beilstein 10 IV 1005.]
p-Coumaric acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from p-Coumaric acid manufacturers
- Product
- 4-Hydroxycinnamic acid 501-98-4
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500mt/year
- Release date
- 2021-07-19
- Product
- p-Coumaric acid 501-98-4
- Price
- US $8.00-5.00/Grams
- Min. Order
- 20Grams
- Purity
- 99.99%
- Supply Ability
- 100Tons
- Release date
- 2023-03-03
- Product
- trans-4-Hydroxycinnamic acid 501-98-4
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 99.92%
- Supply Ability
- 50000tons
- Release date
- 2024-04-28