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Poly(acrylic acid)

Product Name
Poly(acrylic acid)
CAS No.
9003-01-4
Chemical Name
Poly(acrylic acid)
Synonyms
mw;940;xpa;PAA;aron;p11h;r968;0mw);ws24;XPAC
CBNumber
CB8708560
Molecular Formula
C5H10O2
Formula Weight
102.1317
MOL File
9003-01-4.mol
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Poly(acrylic acid) Property

Melting point:
95 °C
Boiling point:
116 °C
Density 
1.2 g/mL at 25 °C
refractive index 
n20/D 1.442
Flash point:
100 °C
storage temp. 
2-8°C
solubility 
Swellable in water and glycerin and, after neutralization, in ethanol (95%). Carbomers do not dissolve but merely swell to a remarkable extent, since they are three-dimensionally crosslinked microgels.
form 
Powder
color 
White
Water Solubility 
Soluble in water.
InChIKey
WLAMNBDJUVNPJU-UHFFFAOYSA-N
IARC
3 (Vol. 19, Sup 7) 1987
EPA Substance Registry System
Polyacrylic acid (9003-01-4)
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Safety

Hazard Codes 
C,T,Xi
Risk Statements 
45-46-34-36/37/38
Safety Statements 
53-45-36-27-26
WGK Germany 
1
RTECS 
AT4680000
TSCA 
Yes
HS Code 
39069090
Toxicity
LD50 oral in rat: 2500mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H340May cause genetic defects

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
181285
Product name
Poly(acrylic acid)
Purity
average Mv ~450,000
Packaging
5g
Price
$48.2
Updated
2020/08/18
Sigma-Aldrich
Product number
181285
Product name
Poly(acrylic acid)
Purity
average Mv ~450,000
Packaging
100g
Price
$349
Updated
2020/08/18
Alfa Aesar
Product number
044669
Product name
Poly(acrylic acid), 25 wt% soln. in water
Packaging
100g
Price
$40.8
Updated
2020/06/24
Alfa Aesar
Product number
044669
Product name
Poly(acrylic acid), 25 wt% soln. in water
Packaging
500g
Price
$138
Updated
2020/06/24
Sigma-Aldrich
Product number
523925
Product name
Poly(acrylic acid) solution
Purity
average Mw ~100,000, 35 wt. % in H2O
Packaging
500ml
Price
$195
Updated
2020/08/18
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Poly(acrylic acid) Chemical Properties,Usage,Production

Description

Acrylic resins are a group of related thermoplastic or thermosetting plastic substances derived from acrylic acid, methacrylic acid or other related compounds.[1] Polymethyl acrylate is an acrylic resin used in an emulsed form for lacquer, textile finishes, adhesives and, mixed with clay, to gloss paper. Another acrylic resin is polymethyl methacrylate which is used to make hard plastics with various light transmitting properties.

Description

For a description of unrelated compounds expanded by twocarbon units,Poly acrylic acid (PAA or Carbomer) is generic name for synthetic high molecular weight polymers of acrylic acid. They may be homopolymers of acrylic acid, crosslinked with an allyl ether pentaerythritol, allyl ether of sucrose or allyl ether of propylene. In a water solution at neutral pH, PAA is an anionic polymer, i.e. many of the side chains of PAA will lose their protons and acquire a negative charge. This makes PAAs polyelectrolytes, with the ability to absorb and retain water and swell to many times their original volume. Dry PAAs are found in the market as white and fluffy powders. Carbomer codes (910, 934, 940, 941 and 934P) are an indication of molecular weight and the specific components of the polymer. For many applications PAAs are used in form of alkali metal or amonium salts e.g. sodium polyacrylate.

Chemical Properties

white powder

Chemical Properties

Carbomers are white-colored, ‘fluffy’, acidic, hygroscopic powders with a characteristic slight odor. A granular carbomer is also available (Carbopol 71G).

Uses

carboxypolymethylene is a binder, film-former and emulsion stabilizer. It can also help increase product viscosity.

Uses

Applications of PAA may include: · to study solute diffusion in Polyvinyl alcohol/PAA copolymer hydrogel · synthesizing poly(N-isopropylacrylamide)-block-PAA copolymer which responds to both temperature and pH stimuli · in preparing block copolymer of oligo (methyl methacrylate)/PAA for micellar delivery of hydrophobic drugs · as thickening agent for adhesives

Definition

ChEBI: An acrylic macromolecule, composed of acrylic acid repeating units.

Application

Poly acrylic acid and its derivatives are used in disposable diapers,ion exchange resins and adhesives. They are also popular as a thickening, dispersing, suspending and emulsifying agents in pharmaceuticals, cosmetics and paints. PAA inactivates the antiseptic chlorhexidine gluconate.

Production Methods

Carbomers are synthetic, high-molecular-weight, crosslinked polymers of acrylic acid. These acrylic acid polymers are crosslinked with allyl sucrose or allyl pentaerythritol. The polymerization solvent used previously was benzene; however, some of the newer commercially available grades of carbomer are manufactured using either ethyl acetate or a cyclohexane–ethyl acetate cosolvent mixture. The Carbopol ETD and Carbopol Ultrez polymers are produced in the cosolvent mixture with a proprietary polymerization aid.

brand name

Carbopol 934 (Noveon).

Pharmaceutical Applications

Carbomers are used in liquid or semisolid pharmaceutical formulations as rheology modifiers. Formulations include creams, gels, lotions and ointments for use in ophthalmic, rectal, topical and vaginal preparations. Carbomer grades with residual benzene content greater than 2 ppm do not meet the specifications of the PhEur 6.4 monograph. However, carbomer having low residuals of other solvents than the ICH-defined ‘Class I OVI solvents’ may be used in Europe. Carbomer having low residuals of ethyl acetate, such as Carbopol 971P NF or Carbopol 974P NF, may be used in oral preparations, in suspensions, capsules or tablets. In tablet formulations, carbomers are used as controlled release agents and/or as binders. In contrast to linear polymers, higher viscosity does not result in slower drug release with carbomers. Lightly crosslinked carbomers (lower viscosity) are generally more efficient in controlling drug release than highly crosslinked carbomers (higher viscosity). In wet granulation processes, water, solvents or their mixtures can be used as the granulating fluid. The tackiness of the wet mass may be reduced by including talc in the formulation or by adding certain cationic species to the granulating fluid. However, the presence of cationic salts may accelerate drug release rates and reduce bioadhesive properties. Carbomer polymers have also been investigated in the preparation of sustained-release matrix beads, as enzyme inhibitors of intestinal proteases in peptide-containing dosage forms, as a bioadhesive for a cervical patch and for intranasally administered microspheres, in magnetic granules for site-specific drug delivery to the esophagus, and in oral mucoadhesive controlled drug delivery systems. Carbomers copolymers are also employed as emulsifying agents in the preparation of oil-in-water emulsions for external administration. Carbomer 951 has been investigated as a viscosity-increasing aid in the preparation of multiple emulsion microspheres. Carbomers are also used in cosmetics. Therapeutically, carbomer formulations have proved efficacious in improving symptoms of moderate-to-severe dry eye syndrome.

Safety

Carbomers are used extensively in nonparenteral products, particularly topical liquid and semisolid preparations. Grades polymerized in ethyl acetate may also be used in oral formulations. There is no evidence of systemic absorption of carbomer polymers following oral administration. Acute oral toxicity studies in animals indicate that carbomer 934P has a low oral toxicity, with doses up to 8 g/kg being administered to dogs without fatalities occurring. Carbomers are generally regarded as essentially nontoxic and nonirritant materials; there is no evidence in humans of hypersensitivity reactions to carbomers used topically.
LD50 (guinea pig, oral): 2.5 g/kg for carbomer 934
LD50 (guinea pig, oral): 2.5 g/kg for carbomer 934P
LD50 (guinea pig, oral): 2.5 g/kg for carbomer 940
LD50 (mouse, IP): 0.04 g/kg for carbomer 934P
LD50 (mouse, IP): 0.04 g/kg for carbomer 940
LD50 (mouse, IV): 0.07 g/kg for carbomer 934P
LD50 (mouse, IV): 0.07 g/kg for carbomer 940
LD50 (mouse, oral): 4.6 g/kg for carbomer 934P
LD50 (mouse, oral): 4.6 g/kg for carbomer 934
LD50 (mouse, oral): 4.6 g/kg for carbomer 940
LD50 (rat, oral): 10.25 g/kg for carbomer 910
LD50 (rat, oral): 2.5 g/kg for carbomer 934P
LD50 (rat, oral): 4.1 g/kg for carbomer 934
LD50 (rat, oral): 2.5 g/kg for carbomer 940
LD50 (rat, oral): > 1g/kg for carbomer 941
No observed adverse effect level (NOAEL) (rat, dog, oral): 1.5 g/kg for carbomer homopolymer type B.

storage

Carbomers are stable, hygroscopic materials that may be heated at temperatures below 1048℃ for up to 2 hours without affecting their thickening efficiency. However, exposure to excessive temperatures can result in discoloration and reduced stability. Complete decomposition occurs with heating for 30 minutes at 2608℃. Dry powder forms of carbomer do not support the growth of molds and fungi. In contrast, microorganisms grow well in unpreserved aqueous dispersions, and therefore an antimicrobial preservative such as 0.1% w/v chlorocresol, 0.18% w/v methylparaben–0.02% w/v propylparaben, or 0.1% w/v thimerosal should be added. The addition of certain antimicrobials, such as benzalkonium chloride or sodium benzoate, in high concentrations (0.1% w/v) can cause cloudiness and a reduction in viscosity of carbomer dispersions. Aqueous gels may be sterilized by autoclaving with minimal changes in viscosity or pH, provided care is taken to exclude oxygen from the system, or by gamma irradiation, although this technique may increase the viscosity of the formulation. At room temperature, carbomer dispersions maintain their viscosity during storage for prolonged periods. Similarly, dispersion viscosity is maintained, or only slightly reduced, at elevated storage temperatures if an antioxidant is included in the formulation or if the dispersion is stored protected from light. Exposure to light causes oxidation that is reflected in a decrease in dispersion viscosity. Stability to light may be improved by the addition of 0.05–0.1% w/v of a water-soluble UV absorber such as benzophenone-2 or benzophenone-4 in combination with 0.05–0.1% w/v edetic acid.
Carbomer powder should be stored in an airtight, corrosionresistant container and protected from moisture. The use of glass, plastic, or resin-lined containers is recommended for the storage of formulations containing carbomer.

Advantages

The advantages of acrylic resins are :
Better stain protection (wash ability)
Water resistance
Better adhesion
Better blocking ('strap down')
Resist cracking and blistering better
Resistance to alkali cleaners.

Current market and forecast

The global demand on acrylic resin approached roughly US $ 14.5 billion in 2011. With an annual growth rate of 4 - 5 % , the acrylic resin market is expected to reach US $ 16.6 billion by 2014 and US$22 billion by 2020. Acrylic resins are used in a wide range of applications for the outstanding chemical characteristics and unique aesthetic properties. Currently, the strongest demand comes from automotive and medical device markets, and paints & coatings, adhesive & sealant and construction & architecture are the major application markets for acrylic resin.

Formulae

Acrylic resin is a general term for any one of the plastics (resin) generated through chemical reaction by applying polymerization initiator and heat to a monomer.
The chemical name for the resin produced from the methyl methacrylate monomer (MMA) is polymethyl methacrylate (PMMA). MMA is a transparent and colorless fluid substance.One of the main characteristic features of PMMA is its high transparency. With its high weather resistance, it has been known to last over 30 years, it does not easily turn yellow or crumble when exposed to sunlight. Polymethyl methacrylate is used not only for transparent windows in aquariums but also for various items such as signboards in places like convenience stores, taillights of automobiles, bathtub liners, sinks, cell phone display screens, backlight optical waveguides for liquid crystal displays (LCD) and so on.

Incompatibilities

Carbomers are discolored by resorcinol and are incompatible with phenol, cationic polymers, strong acids, and high levels of electrolytes. Certain antimicrobial adjuvants should also be avoided or used at low levels. Trace levels of iron and other transition metals can catalytically degrade carbomer dispersions.
Certain amino-functional actives form complexes with carbomer; often this can be prevented by adjusting the pH of the dispersion and/or the solubility parameter by using appropriate alcohols and polyols.
Carbomers also form pH-dependent complexes with certain polymeric excipients. Adjustment of pH and/or solubility parameter can also work in this situation.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral suspensions, tablets; ophthalmic, rectal, topical, transdermal preparations; vaginal suppositories). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

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Poly(acrylic acid) Suppliers

Hubei New Desheng Materials Technology Co., Ltd.
Email
vickyzhao@whdschem.com
Country
China
ProdList
57
Advantage
58
Univar Solutions(China) Co., Ltd.
Tel
021-21932760- ;021-61932733-
Fax
021-60932700
Email
kevin.cheng@univarsolutions.com;ivy.zhuang@univarsolutions.com
Country
China
ProdList
240
Advantage
58
Guangdong Wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886766-
Fax
0751-2886756
Email
3001267247@qq.com;
Country
China
ProdList
10010
Advantage
58
BOC Sciences
Email
info@bocsci.com
Country
United States
ProdList
9983
Advantage
65
HENGSHUI HAOYE CHEMICAL CO.,LTD.
Tel
0318-2102300-
Fax
0318-2103390
Email
hy@chemcoms.com
Country
China
ProdList
219
Advantage
58
Hebei mo Jin biotechnology co., ltd
Tel
Email
sales@hbmojin.com
Country
China
ProdList
419
Advantage
58
Hebei Dj Yan Chemical Co., Ltd.
Tel
311-66561638-
Fax
QQ:672648158
Email
peter@yan-xi.com
Country
China
ProdList
987
Advantage
58
Wuhan yunxiu pharmaceutical technology co. LTD
Tel
Email
3127312836@qq.com
Country
China
ProdList
63
Advantage
58
Sigma-Aldrich
Tel
021-61415566- ;
Email
orderCN@merckgroup.com;orderCN@merckgroup.com
Country
China
ProdList
35534
Advantage
80
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623;022-89880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com;sales@tjzxchem.com
Country
China
ProdList
617
Advantage
60
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View Lastest Price from Poly(acrylic acid) manufacturers

Hebei Lihe Biotechnology Co.,Ltd
Product
XPAC 9003-01-4
Price
US $35.00/KG/Tin
Min. Order
10g
Purity
99%
Supply Ability
10Tons
Release date
2020-10-19
Xingtai Haoxun Import and Export Trade Co., Ltd.
Product
Polyacrylic acid 9003-01-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10tons
Release date
2020-07-16
Shanghai Dumi Biotechnology Co.,Ltd
Product
Polyacrylic acid 9003-01-4
Price
US $40.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
400kg
Release date
2020-12-24

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