ChemicalBook > CAS DataBase List > TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID

TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID

Product Name
TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID
CAS No.
3685-26-5
Chemical Name
TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID
Synonyms
NSC7857;NSC 7857;NSC-7857;Hydroxycyclohexanecarboxylicacid;trans-1-Carboxy-4-hydroxycyclohexane;trans-4-Hydroxycyclohexylcarboxylic acid;TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;trans-4-HydroxycyclohexanecarboxylicAcid>(1r,4r)-4-hydroxycyclohexanecarboxylic acid;trans-4-Hydroxycyclohexane-1-carboxylic acid
CBNumber
CB3727377
Molecular Formula
C7H12O3
Formula Weight
144.17
MOL File
3685-26-5.mol
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TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID Property

Melting point:
145°C
Boiling point:
308℃
Density 
1.246
Flash point:
154℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO, Methanol
pka
pK1:4.687 (25°C)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)/t5-,6-
InChIKey
HCFRWBBJISAZNK-IZLXSQMJSA-N
SMILES
[C@@H]1(C(O)=O)CC[C@@H](O)CC1
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
2916200090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H1175
Product name
trans-4-Hydroxycyclohexanecarboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$69
Updated
2025/07/31
TCI Chemical
Product number
H1175
Product name
trans-4-Hydroxycyclohexanecarboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$205
Updated
2025/07/31
TRC
Product number
H826900
Product name
trans-4-HydroxycyclohexylcarboxylicAcid
Packaging
5g
Price
$110
Updated
2021/12/16
AK Scientific
Product number
Z4662
Product name
trans-4-Hydroxycyclohexanecarboxylic Acid
Packaging
10g
Price
$127
Updated
2021/12/16
ChemScene
Product number
CS-M0763
Product name
trans-4-Hydroxycyclohexanecarboxylic Acid
Purity
≥98.0%
Packaging
25g
Price
$145
Updated
2021/12/16
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TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

trans-4-Hydroxycyclohexylcarboxylic Acid acts as a reagent in the synthetic preparation of pyrazole-pyrimidine preparation as TTK inhibitors and potential antitumors, Preparation and Janus kinase 1 (JAK1)-selective inhibitory activity of benzimidazole derivatives.

Definition

ChEBI: 4-Hydroxycyclohexylcarboxylic acid is a hydroxy monocarboxylic acid.

Synthesis

3618-03-9

3685-22-1

General procedure for the synthesis of cis-4-hydroxycyclohexanecarboxylic acid from methyl cis-4-hydroxycyclohexanecarboxylate: 20 g of methyl cis-4-hydroxycyclohexanecarboxylate was dissolved in 80 mL of methanol and cooled in an ice-water bath. Slowly 40mL of 5 mol/L sodium hydroxide solution was added dropwise, and after completion of the dropwise addition, the reaction mixture was stirred at room temperature overnight. After the reaction was completed, 150 mL of water was added to dilute it. The mixture was extracted twice with ethyl acetate and the organic phase was discarded. The aqueous phase was adjusted to pH 3 with 1 mol/L HCl and extracted twice with 50 mL of ethyl acetate to combine the organic phases. The organic phase was washed twice with saturated saline in turn, dried and decolorized. After filtration, ethyl acetate was recovered by distillation under reduced pressure to give 16 g of white solid product cis-4-hydroxycyclohexanecarboxylic acid in 90% yield.

References

[1] Patent: CN105061424, 2016, B. Location in patent: Paragraph 0029; 0031

TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID Suppliers

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View Lastest Price from TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
trans-4-Hydroxycyclohexanecarboxylic acid 3685-26-5
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-24
Shaanxi Dideu Medichem Co. Ltd
Product
TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID 3685-26-5
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-19
Kindchem(Nanjing)Co.,Ltd
Product
Hydroxycyclohexanecarboxylicacid 3685-26-5
Price
US $0.00-0.00/g
Min. Order
100g
Purity
98%
Supply Ability
100kg
Release date
2023-08-10

3685-26-5, TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACIDRelated Search:

trans-4-Methylcyclohexylamine hydrochloride trans-Methyl4-hydroxycyclohexanecarboxylate trans-4-MethoxycyclohexanaMine HCl trans-4-Methylcyclohexyl amine p-Coumaric acid trans-4-Methycyclohexyl isocyanate 4-METHOXY-3-BUTEN-2-ONE trans-3-FluorocyclobutanaMine hydrochloride trans-3-Aminocyclobutanol H-HYP-OBZL HCL trans-2,5-Dimethylpiperazine (TRANS)-3-AMINOCYCLOBUTANOL ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate Brassinolide Azadirachtin Chlorogenic acid 4-METHOXYCYCLOHEXANECARBOXYLIC ACID cis-4-Hydroxycyclohexanecarboxylic acid

  • TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID
  • Hydroxycyclohexanecarboxylicacid
  • trans-1-Carboxy-4-hydroxycyclohexane
  • trans-4-Hydroxycyclohexane-1-carboxylic acid
  • (1r,4r)-4-hydroxycyclohexanecarboxylic acid
  • <i>trans</i>-4-Hydroxycyclohexanecarboxylic Acid
  • Cyclohexanecarboxylicacid, 4-hydroxy-, trans-
  • trans-4-Hydroxycyclohexylcarboxylic acid
  • trans-4-HydroxycyclohexanecarboxylicAcid&gt
  • NSC 7857
  • NSC7857
  • NSC-7857
  • trans-4-Hydroxycyclohexanecarboxylic Acid, ≥ 95.0%
  • trans-4-Hydroxycyclohexanecarboxylic Acid, 10 mM in DMSO
  • 3685-26-5
  • Building Blocks for Liquid Crystals
  • Chalcones, etc. (Building Blocks for Liquid Crystals)
  • 4-Substituted Cyclohexanecarboxylic Acids
  • chiral
  • 4-Substituted Cyclohexanecarboxylic Acids
  • Building Blocks for Liquid Crystals
  • Chalcones, etc. (Building Blocks for Liquid Crystals)
  • Functional Materials